Rv2593c

Tuberculist information
Gene nameruvA
Protein functionProbable holliday junction DNA helicase RuvA
Functional category(tuberculist)information pathways
Gene location(kb)2924.23
Molecular mass(da)20189.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 196
	  		  	1    MIASVRGEVLEVALDHVVIEAAGVGYRVNATPATLATLRQGTEARLITAMIVREDSMTLY   60
			  	61   GFPDGETRDLFLTLLSVSGVGPRLAMAALAVHDAPALRQVLADGNVAALTRVPGIGKRGA  120
			  	121  ERMVLELRDKVGVAATGGALSTNGHAVRSPVVEALVGLGFAAKQAEEATDTVLAANHDAT  180
			  	181  TSSALRSALSLLGKAR

Known structures in the PDB
PDB ID2H5X
Total residue count784
Number of chains4
MethodX-RAY
Resolution2.7
PDB ID2ZTC
Total residue count848
Number of chains4
MethodX-RAY
Resolution2.8
PDB ID2ZTD
Total residue count424
Number of chains2
MethodX-RAY
Resolution2.4
PDB ID2ZTE
Total residue count212
Number of chains1
MethodX-RAY
Resolution3.2
1 20 39 58 77 96 115 134 153 172 191 Range: 1 to 61  |  Coverage: 30% RuvA_N Range: 68 to 129  |  Coverage: 31% HHH_5 Range: 146 to 193  |  Coverage: 23% RuvA_C Range: to 6  |  Coverage: 3% 1 Range: 1 to 196  |  Coverage: 99% 2 Range: 1 to 196  |  Coverage: 99% 1 Range: 1 to 139  |  Coverage: 70% 2 Range: 1 to 63  |  Coverage: 31% 3 Range: 62 to 141  |  Coverage: 40% 4 Range: 141 to 196  |  Coverage: 28% 5
Number of amino acids : 196
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
RuvA_NPF013301-61
HHH_5PF1452068-129
RuvA_CPF07499146-193
Mtb Structural Proteome models
Model Number1
Model nameRv2593c_2ztd_A
Template2ZTD    APDBCREDO
Template coverage0_195
Template Identity(%)100.0
Model coverage(%)99.5
Normalized DOPE score-0.889

Model Number2
Model nameRv2593c
Template1BVS    APDBCREDO
Template coverage1_203
Template Identity(%)80.9
Model coverage(%)99.5
Normalized DOPE score0.378

Structure Models from Chopin
Model Number1
Profilea.5.1.1, a.60.2.1, b.40.4.2 - 1.10.150.20, 1.10.8.10, 2.40.50.140
Click for model details
zscore43.9
Residue begin1
Residue end196
Model Number2
Profilea.60.2.1, b.40.4.2 - 1.10.150.20, 2.40.50.140
Click for model details
zscore30.21
Residue begin1
Residue end139
Model Number3
Profileb.40.4.2
Click for model details
zscore22.34
Residue begin1
Residue end63
Model Number4
Profilea.60.2.1
Click for model details
zscore21.35
Residue begin62
Residue end141
Model Number5
Profilea.5.1.1
Click for model details
zscore13.63
Residue begin141
Residue end196
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2593cGene nameConfidence Score
Rv2592cruvB0.999
Rv2592cruvB0.999
Rv2594cruvC0.999
Rv1638uvrA0.984
Rv1633uvrB0.978
Rv1633uvrB0.978
Rv1633uvrB0.978
Rv1633uvrB0.978
Rv0631crecC0.969
Rv2720lexA0.968
Rv2720lexA0.968
Rv1696recN0.967
Rv0003recF0.966
Rv3715crecR0.964
Rv3715crecR0.964
Rv3715crecR0.964
Rv2737crecA0.96
Rv2737crecA0.96
Rv0629crecD0.954
Rv0629crecD0.954
Rv2973crecG0.95
Rv2973crecG0.95
Rv2973crecG0.95
Rv0054ssb0.94
Rv1020mfd0.926
Rv1020mfd0.926
Rv1020mfd0.926
Rv1020mfd0.926
Rv1420uvrC0.921
Rv1420uvrC0.921
Rv1420uvrC0.921
Rv1420uvrC0.921
Rv0001dnaA0.919
Rv0001dnaA0.919
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
glycerolPubChem0.90392.0938
RuvA proteinPubChem0.853361.48