Rv0001

Tuberculist information
Gene namednaA
Protein functionChromosomal replication initiator protein DnaA
Functional category(tuberculist)information pathways
Gene location(kb)0.001
Molecular mass(da)56548.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 507
	  		  	1    LTDDPGSGFTTVWNAVVSELNGDPKVDDGPSSDANLSAPLTPQQRAWLNLVQPLTIVEGF   60
			  	61   ALLSVPSSFVQNEIERHLRAPITDALSRRLGHQIQLGVRIAPPATDEADDTTVPPSENPA  120
			  	121  TTSPDTTTDNDEIDDSAAARGDNQHSWPSYFTERPHNTDSATAGVTSLNRRYTFDTFVIG  180
			  	181  ASNRFAHAAALAIAEAPARAYNPLFIWGESGLGKTHLLHAAGNYAQRLFPGMRVKYVSTE  240
			  	241  EFTNDFINSLRDDRKVAFKRSYRDVDVLLVDDIQFIEGKEGIQEEFFHTFNTLHNANKQI  300
			  	301  VISSDRPPKQLATLEDRLRTRFEWGLITDVQPPELETRIAILRKKAQMERLAVPDDVLEL  360
			  	361  IASSIERNIRELEGALIRVTAFASLNKTPIDKALAEIVLRDLIADANTMQISAATIMAAT  420
			  	421  AEYFDTTVEELRGPGKTRALAQSRQIAMYLCRELTDLSLPKIGQAFGRDHTTVMYAQRKI  480
			  	481  LSEMAERREVFDHVKELTTRIRQRSKR

Known structures in the PDB
PDB ID3PVP
Total residue count254
Number of chains6
MethodX-RAY
Resolution2.3
PDB ID3PVV
Total residue count254
Number of chains6
MethodX-RAY
Resolution2
1 51 101 151 201 251 301 351 401 451 501 Range: 168 to 386  |  Coverage: 42% Bac_DnaA Range: 412 to 480  |  Coverage: 13% Bac_DnaA_C Range: 166 to 504  |  Coverage: 66% 1 Range: 166 to 506  |  Coverage: 67% 1 Range: 400 to 507  |  Coverage: 21% 2 Range: 168 to 386  |  Coverage: 42% 3
Number of amino acids : 507
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Bac_DnaAPF00308168-386
Bac_DnaA_CPF08299412-480
Mtb Structural Proteome models
Model Number1
Model nameRv0001
Template1L8Q    APDBCREDO
Template coverage77_397
Template Identity(%)34.8
Model coverage(%)66.7
Normalized DOPE score-0.437

Structure Models from Chopin
Model Number1
Profilea.4.12.2, c.37.1.20 - 1.10.1750.10, 1.10.8.60, 3.40.50.300
Click for model details
zscore57.69
Residue begin166
Residue end506
Model Number2
Profilea.4.12.2 - 1.10.1750.10
Click for model details
zscore28.07
Residue begin400
Residue end507
Model Number3
Profilec.37.1.20
Click for model details
zscore12.56
Residue begin168
Residue end386
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0001Gene nameConfidence Score
Rv0002dnaN0.998
Rv0002dnaN0.998
Rv0002dnaN0.998
Rv0003recF0.997
Rv0005gyrB0.994
Rv0005gyrB0.994
Rv0005gyrB0.994
Rv0005gyrB0.994
Rv0006gyrA0.993
Rv0006gyrA0.993
Rv3924crpmH0.992
Rv0667rpoB0.987
Rv0667rpoB0.987
Rv0667rpoB0.987
Rv0667rpoB0.987
Rv0667rpoB0.987
Rv0667rpoB0.987
Rv0058dnaB0.977
Rv0058dnaB0.977
Rv0058dnaB0.977
Rv0058dnaB0.977
Rv2150cftsZ0.965
Rv2150cftsZ0.965
Rv3917cparB0.96
Rv3917cparB0.96
Rv3919cgid0.959
Rv2594cruvC0.943
Rv3610cftsH0.941
Rv3610cftsH0.941
Rv3610cftsH0.941
Rv0350dnaK0.925
Rv1629polA0.922
Rv1629polA0.922
Rv1629polA0.922
Rv1020mfd0.919
Rv2593cruvA0.919
Rv1020mfd0.919
Rv2593cruvA0.919
Rv1020mfd0.919
Rv1020mfd0.919
Rv2593cruvA0.919
Rv2720lexA0.916
Rv2720lexA0.916
Rv2592cruvB0.912
Rv2592cruvB0.912
Rv2412rpsT0.906
Rv0707rpsC0.906
Rv0707rpsC0.906
Rv1638uvrA0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
magnesiumPubChem0.78824.305
adenosine diphosphatePubChem0.777427.201
selenomethioninePubChem0.776196.106
SeMetPubChem0.776196.106
glycerolPubChem0.70292.0938
mitomycin CPubChem0.702334.327