Rv1638

Tuberculist information
Gene nameuvrA
Protein functionProbable excinuclease ABC (subunit A - DNA-binding ATPase) UvrA
Functional category(tuberculist)information pathways
Gene location(kb)1843.74
Molecular mass(da)106099
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 972
	  		  	1    VADRLIVKGAREHNLRSVDLDLPRDALIVFTGLSGSGKSSLAFDTIFAEGQRRYVESLSA   60
			  	61   YARQFLGQMDKPDVDFIEGLSPAVSIDQKSTNRNPRSTVGTITEVYDYLRLLYARAGTPH  120
			  	121  CPTCGERVARQTPQQIVDQVLAMPEGTRFLVLAPVVRTRKGEFADLFDKLNAQGYSRVRV  180
			  	181  DGVVHPLTDPPKLKKQEKHDIEVVVDRLTVKAAAKRRLTDSVETALNLADGIVVLEFVDH  240
			  	241  ELGAPHREQRFSEKLACPNGHALAVDDLEPRSFSFNSPYGACPECSGLGIRKEVDPELVV  300
			  	301  PDPDRTLAQGAVAPWSNGHTAEYFTRMMAGLGEALGFDVDTPWRKLPAKARKAILEGADE  360
			  	361  QVHVRYRNRYGRTRSYYADFEGVLAFLQRKMSQTESEQMKERYEGFMRDVPCPVCAGTRL  420
			  	421  KPEILAVTLAGESKGEHGAKSIAEVCELSIADCADFLNALTLGPREQAIAGQVLKEIRSR  480
			  	481  LGFLLDVGLEYLSLSRAAATLSGGEAQRIRLATQIGSGLVGVLYVLDEPSIGLHQRDNRR  540
			  	541  LIETLTRLRDLGNTLIVVEHDEDTIEHADWIVDIGPGAGEHGGRIVHSGPYDELLRNKDS  600
			  	601  ITGAYLSGRESIEIPAIRRSVDPRRQLTVVGAREHNLRGIDVSFPLGVLTSVTGVSGSGK  660
			  	661  STLVNDILAAVLANRLNGARQVPGRHTRVTGLDYLDKLVRVDQSPIGRTPRSNPATYTGV  720
			  	721  FDKIRTLFAATTEAKVRGYQPGRFSFNVKGGRCEACTGDGTIKIEMNFLPDVYVPCEVCQ  780
			  	781  GARYNRETLEVHYKGKTVSEVLDMSIEEAAEFFEPIAGVHRYLRTLVDVGLGYVRLGQPA  840
			  	841  PTLSGGEAQRVKLASELQKRSTGRTVYILDEPTTGLHFDDIRKLLNVINGLVDKGNTVIV  900
			  	901  IEHNLDVIKTSDWIIDLGPEGGAGGGTVVAQGTPEDVAAVPASYTGKFLAEVVGGGASAA  960
			  	961  TSRSNRRRNVSA

Known structures in the PDB
PDB ID3ZQJ
Total residue count5958
Number of chains6
MethodX-RAY
Resolution3.4
1 98 195 292 389 486 583 680 777 874 971 Range: 410 to 530  |  Coverage: 12% ABC_tran Range: 661 to 874  |  Coverage: 21% ABC_tran Range: 379 to 970  |  Coverage: 60% 1 Range: 814 to 909  |  Coverage: 9% 1 Range: 625 to 733  |  Coverage: 11% 2 Range: 1 to 144  |  Coverage: 14% 3 Range: 388 to 531  |  Coverage: 14% 4
Number of amino acids : 972
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ABC_tranPF00005410-530
ABC_tranPF00005661-874
Mtb Structural Proteome models
Model Number1
Model nameRv1638
Template1YQT    APDBCREDO
Template coverage96_575
Template Identity(%)21.2
Model coverage(%)60.8
Normalized DOPE score1.016

Structure Models from Chopin
Model Number1
Profilec.37.1.12 - 3.40.50.300
Click for model details
zscore9.17
Residue begin814
Residue end909
Model Number2
Profilec.37.1.12
Click for model details
zscore5.5
Residue begin625
Residue end733
Model Number3
Profilec.37.1.12 - 3.40.50.300
Click for model details
zscore5.16
Residue begin1
Residue end144
Model Number4
Profilec.37.1.12 - 3.40.50.300
Click for model details
zscore5.16
Residue begin388
Residue end531
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1638Gene nameConfidence Score
Rv1633uvrB0.999
Rv1633uvrB0.999
Rv1633uvrB0.999
Rv1633uvrB0.999
Rv1020mfd0.998
Rv1020mfd0.998
Rv1020mfd0.998
Rv1020mfd0.998
Rv1420uvrC0.997
Rv1420uvrC0.997
Rv1420uvrC0.997
Rv1420uvrC0.997
Rv1696recN0.993
Rv0949uvrD10.987
Rv0949uvrD10.987
Rv2593cruvA0.984
Rv2593cruvA0.984
Rv2593cruvA0.984
Rv0054ssb0.974
Rv2720lexA0.969
Rv2720lexA0.969
Rv3014cligA0.966
Rv3014cligA0.966
Rv3014cligA0.966
Rv3014cligA0.966
Rv3014cligA0.966
Rv1629polA0.963
Rv1629polA0.963
Rv1629polA0.963
Rv2973crecG0.953
Rv2973crecG0.953
Rv2973crecG0.953
Rv3610cftsH0.951
Rv3610cftsH0.951
Rv3610cftsH0.951
Rv3913trxB20.949
Rv3913trxB20.949
Rv2592cruvB0.94
Rv2592cruvB0.94
Rv1617pykA0.931
Rv1617pykA0.931
Rv2737crecA0.93
Rv2737crecA0.93
Rv3198cuvrD20.926
Rv3198cuvrD20.926
Rv3198cuvrD20.926
Rv2594cruvC0.923
Rv1316cogt0.921
Rv1316cogt0.921
Rv3056dinP0.92
Rv3056dinP0.92
Rv0006gyrA0.915
Rv0006gyrA0.915
Rv3834cserS0.912
Rv3834cserS0.912
Rv2462ctig0.911
Rv2462ctig0.911
Rv2462ctig0.911
Rv0003recF0.906
Rv0001dnaA0.901
Rv0001dnaA0.901
Rv2882cfrr0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
mitomycin CPubChem0.917334.327
pMALPubChem0.763313.147
Lys-Phe-His-Glu-Lys-His-His-Ser-His-Arg-Gly-TyrPubChem0.741562.69
4-nitroquinoline 1-oxidePubChem0.718190.156
methyl methanesulfonatePubChem0.716110.132
L-lysyl-L-tryptophyl-L-lysinePubChem0.713460.57
Lys-Trp-LysPubChem0.71460.57