Rv1629

Tuberculist information
Gene namepolA
Protein functionProbable DNA polymerase I PolA
Functional category(tuberculist)information pathways
Gene location(kb)1830.67
Molecular mass(da)98440
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 904
	  		  	1    VVTTASAPSEDRAKPTLMLLDGNSLAFRAFYALPAENFKTRGGLTTNAVYGFTAMLINLL   60
			  	61   RDEAPTHIAAAFDVSRQTFRLQRYPEYKANRSSTPDEFAGQIDITKEVLGALGITVLSEP  120
			  	121  GFEADDLIATLATQAENEGYRVLVVTGDRDALQLVSDDVTVLYPRKGVSELTRFTPEAVV  180
			  	181  EKYGLTPRQYPDFAALRGDPSDNLPGIPGVGEKTAAKWIAEYGSLRSLVDNVDAVRGKVG  240
			  	241  DALRANLASVVRNRELTDLVRDVPLAQTPDTLRLQPWDRDHIHRLFDDLEFRVLRDRLFD  300
			  	301  TLAAAGGPEVDEGFDVRGGALAPGTVRQWLAEHAGDGRRAGLTVVGTHLPHGGDATAMAV  360
			  	361  AAADGEGAYLDTATLTPDDDAALAAWLADPAKPKALHEAKAAVHDLAGRGWTLEGVTSDT  420
			  	421  ALAAYLVRPGQRSFTLDDLSLRYLRRELRAETPQQQQLSLLDDDDTDAETIQTTILRARA  480
			  	481  VIDLADALDAELARIDSTALLGEMELPVQRVLAKMESAGIAVDLPMLTELQSQFGDQIRD  540
			  	541  AAEAAYGVIGKQINLGSPKQLQVVLFDELGMPKTKRTKTGYTTDADALQSLFDKTGHPFL  600
			  	601  QHLLAHRDVTRLKVTVDGLLQAVAADGRIHTTFNQTIAATGRLSSTEPNLQNIPIRTDAG  660
			  	661  RRIRDAFVVGDGYAELMTADYSQIEMRIMAHLSGDEGLIEAFNTGEDLHSFVASRAFGVP  720
			  	721  IDEVTGELRRRVKAMSYGLAYGLSAYGLSQQLKISTEEANEQMDAYFARFGGVRDYLRAV  780
			  	781  VERARKDGYTSTVLGRRRYLPELDSSNRQVREAAERAALNAPIQGSAADIIKVAMIQVDK  840
			  	841  ALNEAQLASRMLLQVHDELLFEIAPGERERVEALVRDKMGGAYPLDVPLEVSVGYGRSWD  900
			  	901  AAAH

Known structures in the PDB
No Known structures
1 91 181 271 361 451 541 631 721 811 901 Range: 15 to 183  |  Coverage: 18% 5_3_exonuc_N Range: 185 to 284  |  Coverage: 10% 5_3_exonuc Range: 522 to 902  |  Coverage: 42% DNA_pol_A Range: 12 to 902  |  Coverage: 98% 1 Range: 4 to 904  |  Coverage: 99% 1 Range: 518 to 634  |  Coverage: 12% 2 Range: 15 to 183  |  Coverage: 18% 3 Range: 1 to 308  |  Coverage: 33% 4 Range: 774 to 902  |  Coverage: 14% 5 Range: 183 to 326  |  Coverage: 15% 6 Range: 350 to 492  |  Coverage: 15% 7
Number of amino acids : 904
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
5_3_exonuc_NPF0273915-183
5_3_exonucPF01367185-284
DNA_pol_APF00476522-902
Mtb Structural Proteome models
Model Number1
Model nameRv1629
Template1BGX    TPDBCREDO
Template coverage9_830
Template Identity(%)39.9
Model coverage(%)98.5
Normalized DOPE score1.003

Structure Models from Chopin
Model Number1
Profilea.60.7.1, c.120.1.2, c.55.3.5, e.8.1.1 - 1.10.150.20, 1.20.1060.10, 3.30.420.10, 3.30.70.370, 3.40.50.1010
Click for model details
zscore103.11
Residue begin4
Residue end904
Model Number2
Profile1.20.1060.10
Click for model details
zscore28.31
Residue begin518
Residue end634
Model Number3
Profilec.120.1.2
Click for model details
zscore27.13
Residue begin15
Residue end183
Model Number4
Profilea.60.7.1, c.120.1.2 - 1.10.150.20, 3.40.50.1010
Click for model details
zscore23.16
Residue begin1
Residue end308
Model Number5
Profile3.30.70.370
Click for model details
zscore20.63
Residue begin774
Residue end902
Model Number6
Profilea.60.7.1
Click for model details
zscore16.25
Residue begin183
Residue end326
Model Number7
Profilec.55.3.5 - 3.30.420.10
Click for model details
zscore4.13
Residue begin350
Residue end492
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1629Gene nameConfidence Score
Rv1617pykA0.975
Rv1617pykA0.975
Rv1633uvrB0.97
Rv1633uvrB0.97
Rv1633uvrB0.97
Rv1633uvrB0.97
Rv1547dnaE10.965
Rv1547dnaE10.965
Rv1547dnaE10.965
Rv1547dnaE10.965
Rv1638uvrA0.963
Rv1316cogt0.95
Rv1316cogt0.95
Rv2924cfpg0.945
Rv2924cfpg0.945
Rv2924cfpg0.945
Rv2344cdgt0.942
Rv2344cdgt0.942
Rv0001dnaA0.922
Rv0001dnaA0.922
Rv2445cndkA0.92
Rv3646ctopA0.917
Rv3646ctopA0.917
Rv3646ctopA0.917
Rv1631coaE0.911
Rv1631coaE0.911
Rv2594cruvC0.904
Rv1020mfd0.903
Rv1020mfd0.903
Rv1020mfd0.903
Rv1020mfd0.903
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
deoxycytidine triphosphatePubChem0.935467.157
thymidine triphosphatePubChem0.925482.168
deoxyadenosine triphosphatePubChem0.9491.182
deoxyguanosine triphosphatePubChem0.9507.181
pyrophosphatePubChem0.9177.975
magnesiumPubChem0.80424.305
manganesePubChem0.73454.938