SInCRe - Rv2924c

Tuberculist information

Gene name	fpg
Protein function	Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA glycosylase)
Functional category(tuberculist)	information pathways
Gene location(kb)	3238.6
Molecular mass(da)	31950.7
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 289

	  		  	1    MPELPEVEVVRRGLQAHVTGRTITEVRVHHPRAVRRHDAGPADLTARLRGARINGTDRRG   60
			  	61   KYLWLTLNTAGVHRPTDTALVVHLGMSGQMLLGAVPCAAHVRISALLDDGTVLSFADQRT  120
			  	121  FGGWLLADLVTVDGSVVPVPVAHLARDPLDPRFDCDAVVKVLRRKHSELKRQLLDQRVVS  180
			  	181  GIGNIYADEALWRAKVNGAHVAATLRCRRLGAVLHAAADVMREALAKGGTSFDSLYVNVN  240
			  	241  GESGYFERSLDAYGREGENCRRCGAVIRRERFMNRSSFYCPRCQPRPRK

Known structures in the PDB

No Known structures

Number of amino acids : 289

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
Fapy_DNA_glyco	PF01149	2-125
H2TH	PF06831	144-234
zf-FPG_IleRS	PF06827	257-286

Mtb Structural Proteome models

Model Number	1
Model name	Rv2924c
Template	1R2Z APDB CREDO
Template coverage	2_273
Template Identity(%)	36.4
Model coverage(%)	97.6
Normalized DOPE score	-0.201

Structure Models from Chopin

Model Number	1
Profile	a.156.1.2, b.113.1.1, g.39.1.8 - 1.10.8.50, 3.20.190.10 Click for model details
zscore	55.38
Residue begin	2
Residue end	288

Model Number	2
Profile	3.20.190.10 Click for model details
zscore	27.32
Residue begin	2
Residue end	140

Model Number	3
Profile	a.156.1.2 Click for model details
zscore	16.74
Residue begin	143
Residue end	238

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv2924c	Gene name	Confidence Score
Rv2976c	ung	0.971
Rv3589	mutY	0.965
Rv3589	mutY	0.965
Rv3674c	nth	0.963
Rv3674c	nth	0.963
Rv3674c	nth	0.963
Rv1629	polA	0.945
Rv1629	polA	0.945
Rv1629	polA	0.945
Rv0670	end	0.938
Rv1633	uvrB	0.913
Rv1633	uvrB	0.913
Rv1633	uvrB	0.913
Rv1633	uvrB	0.913

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
8-oxoguaninePubChem	0.853	167.126
5-hydroxycytosinePubChem	0.85	127.101
FapyPubChem	0.833	381.236
formamidopyrimidinePubChem	0.828	123.113
zincPubChem	0.823	65.409
dihydrouracilPubChem	0.821	114.103
5-hydroxyuracilPubChem	0.797	128.086
8-oxoGPubChem	0.794	299.24
thymine glycolPubChem	0.779	160.128
8-hydroxyadeninePubChem	0.715	151.126