Rv0670

Tuberculist information
Gene nameend
Protein functionProbable endonuclease IV End (endodeoxyribonuclease IV) (apurinase)
Functional category(tuberculist)information pathways
Gene location(kb)769.792
Molecular mass(da)26813.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 252
	  		  	1    VLIGSHVSPTDPLAAAEAEGADVVQIFLGNPQSWKAPKPRDDAAALKAATLPIYVHAPYL   60
			  	61   INLASANNRVRIPSRKILQETCAAAADIGAAAVIVHGGHVADDNDIDKGFQRWRKALDRL  120
			  	121  ETEVPVYLENTAGGDHAMARRFDTIARLWDVIGDTGIGFCLDTCHTWAAGEALTDAVDRI  180
			  	181  KAITGRIDLVHCNDSRDEAGSGRDRHANLGSGQIDPDLLVAAVKAAGAPVICETADQGRK  240
			  	241  DDIAFLRERTGS

Known structures in the PDB
No Known structures
1 26 51 76 101 126 151 176 201 226 251 Range: 13 to 214  |  Coverage: 79% AP_endonuc_2 Range: 2 to 250  |  Coverage: 98% 1 Range: 1 to 252  |  Coverage: 99% 1
Number of amino acids : 252
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
AP_endonuc_2PF0126113-214
Mtb Structural Proteome models
Model Number1
Model nameRv0670
Template1QTW    APDBCREDO
Template coverage3_279
Template Identity(%)27.7
Model coverage(%)98.4
Normalized DOPE score-0.418

Structure Models from Chopin
Model Number1
Profilec.1.15.1 - 3.20.20.150
Click for model details
zscore45.18
Residue begin1
Residue end252
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0670Gene nameConfidence Score
Rv3674cnth0.989
Rv3674cnth0.989
Rv3674cnth0.989
Rv2924cfpg0.938
Rv2924cfpg0.938
Rv2924cfpg0.938
Rv2976cung0.937
Rv1420uvrC0.906
Rv1420uvrC0.906
Rv1420uvrC0.906
Rv1420uvrC0.906
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
zincPubChem0.83865.409
phosphatePubChem0.75696.9872
hydron diphosphatePubChem0.713391.981