Rv2976c

Tuberculist information
Gene nameung
Protein functionProbable uracil-DNA glycosylase Ung (UDG)
Functional category(tuberculist)information pathways
Gene location(kb)3332.07
Molecular mass(da)24449.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 227
	  		  	1    VTARPLSELVERGWAAALEPVADQVAHMGQFLRAEIAAGRRYLPAGSNVLRAFTFPFDNV   60
			  	61   RVLIVGQDPYPTPGHAVGLSFSVAPDVRPWPRSLANIFDEYTADLGYPLPSNGDLTPWAQ  120
			  	121  RGVLLLNRVLTVRPSNPASHRGKGWEAVTECAIRALAARAAPLVAILWGRDASTLKPMLA  180
			  	181  AGNCVAIESPHPSPLSASRGFFGSRPFSRANELLVGMGAEPIDWRLP

Known structures in the PDB
PDB ID2ZHX
Total residue count2254
Number of chains14
MethodX-RAY
Resolution3.1
PDB ID3A7N
Total residue count238
Number of chains1
MethodX-RAY
Resolution1.95
1 23 45 67 89 111 133 155 177 199 221 Range: 53 to 215  |  Coverage: 71% UDG Range: to 5  |  Coverage: 2% 1 Range: 14 to 227  |  Coverage: 93% 2 Range: 1 to 227  |  Coverage: 99% 1
Number of amino acids : 227
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
UDGPF0316753-215
Mtb Structural Proteome models
Model Number1
Model nameRv2976c_3a7n_A
Template3A7N    APDBCREDO
Template coverage0_227
Template Identity(%)100.0
Model coverage(%)100.0
Normalized DOPE score-2.315

Model Number2
Model nameRv2976c
Template2BOO    APDBCREDO
Template coverage27_241
Template Identity(%)48.6
Model coverage(%)93.8
Normalized DOPE score-1.452

Structure Models from Chopin
Model Number1
Profile3.40.470.10
Click for model details
zscore50.96
Residue begin1
Residue end227
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2976cGene nameConfidence Score
Rv3589mutY0.984
Rv3589mutY0.984
Rv2697cdut0.972
Rv2924cfpg0.971
Rv2924cfpg0.971
Rv2924cfpg0.971
Rv3674cnth0.963
Rv3674cnth0.963
Rv3674cnth0.963
Rv2764cthyA0.956
Rv2445cndkA0.941
Rv0670end0.937
Rv1633uvrB0.91
Rv1633uvrB0.91
Rv1633uvrB0.91
Rv1633uvrB0.91
Rv0005gyrB0.908
Rv0005gyrB0.908
Rv0005gyrB0.908
Rv0005gyrB0.908
Rv1848ureA0.905
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
uracilPubChem0.946112.087
citratePubChem0.902192.124
dUMPPubChem0.738308.182