Rv3589

Tuberculist information
Gene namemutY
Protein functionProbable adenine glycosylase MutY
Functional category(tuberculist)information pathways
Gene location(kb)4030.49
Molecular mass(da)33684.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 304
	  		  	1    MPHILPEPSVTGPRHISDTNLLAWYQRSHRDLPWREPGVSPWQILVSEFMLQQTPAARVL   60
			  	61   AIWPDWVRRWPTPSATATASTADVLRAWGKLGYPRRAKRLHECATVIARDHNDVVPDDIE  120
			  	121  ILVTLPGVGSYTARAVACFAYRQRVPVVDTNVRRVVARAVHGRADAGAPSVPRDHADVLA  180
			  	181  LLPHRETAPEFSVALMELGATVCTARTPRCGLCPLDWCAWRHAGYPPSDGPPRRGQAYTG  240
			  	241  TDRQVRGRLLDVLRAAEFPVTRAELDVAWLTDTAQRDRALESLLADALVTRTVDGRFALP  300
			  	301  GEGF

Known structures in the PDB
No Known structures
1 31 61 91 121 151 181 211 241 271 301 Range: 46 to 180  |  Coverage: 44% HhH-GPD Range: 110 to 139  |  Coverage: 9% HHH Range: 13 to 290  |  Coverage: 91% 1 Range: 7 to 236  |  Coverage: 75% 1 Range: 31 to 144  |  Coverage: 37% 2
Number of amino acids : 304
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
HhH-GPDPF0073046-180
HHHPF00633110-139
Mtb Structural Proteome models
Model Number1
Model nameRv3589
Template1RRQ    APDBCREDO
Template coverage9_302
Template Identity(%)32.0
Model coverage(%)91.1
Normalized DOPE score-0.196

Structure Models from Chopin
Model Number1
Profilea.96.1.2 - 1.10.340.30
Click for model details
zscore41.17
Residue begin7
Residue end236
Model Number2
Profile1.10.340.30
Click for model details
zscore13.08
Residue begin31
Residue end144
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3589Gene nameConfidence Score
Rv1160mutT20.992
Rv2976cung0.984
Rv2924cfpg0.965
Rv2924cfpg0.965
Rv2924cfpg0.965
Rv1611trpC0.914
Rv1633uvrB0.912
Rv1633uvrB0.912
Rv1633uvrB0.912
Rv1633uvrB0.912
Rv1420uvrC0.911
Rv1420uvrC0.911
Rv1420uvrC0.911
Rv1420uvrC0.911
Rv0427cxthA0.91
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
8-oxoGPubChem0.935299.24
8-oxyguaninePubChem0.928165.11
adeninePubChem0.879135.127
8-oxoguaninePubChem0.84167.126
berberinePubChem0.769336.361
guaninePubChem0.732151.126
rifampicinPubChem0.702822.94