Rv0427c

Tuberculist information
Gene namexthA
Protein functionProbable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)
Functional category(tuberculist)information pathways
Gene location(kb)516.017
Molecular mass(da)32108.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 291
	  		  	1    MPDGTIDGGHPQRPASPRLRSPLLRLATWNVNSIRTRLDRVLDWLGRADVDVLAMQETKC   60
			  	61   PDGQFPALPLFELGYDVAHVGFDQWNGVAIASRVGLDDVRVGFDGQPSWSGKPEVAATTE  120
			  	121  ARALGATCGGIRVWSLYVPNGRALDDPHYTYKLDWLAALRDTAEGWLRDDPAAPIALMGD  180
			  	181  WNIAPTDDDVWSTEFFAGCTHVSEPERKAFNAIVDAQFTDVVRPFTPGPGVYTYWDYTQL  240
			  	241  RFPKKQGMRIDFILGSPALAARVMDAQIVREERKGKAPSDHAPVLVDLHAG

Known structures in the PDB
No Known structures
1 30 59 88 117 146 175 204 233 262 291 Range: 27 to 281  |  Coverage: 87% Exo_endo_phos Range: 10 to 290  |  Coverage: 96% 1 Range: 1 to 291  |  Coverage: 99% 1
Number of amino acids : 291
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Exo_endo_phosPF0337227-281
Mtb Structural Proteome models
Model Number1
Model nameRv0427c
Template1HD7    APDBCREDO
Template coverage48_318
Template Identity(%)27.8
Model coverage(%)96.2
Normalized DOPE score-0.07

Structure Models from Chopin
Model Number1
Profiled.151.1.1 - 3.60.10.10
Click for model details
zscore28.73
Residue begin1
Residue end291
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0427cGene nameConfidence Score
Rv3674cnth0.941
Rv3674cnth0.941
Rv3674cnth0.941
Rv3589mutY0.91
Rv3589mutY0.91
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
magnesiumPubChem0.89724.305
phosphatePubChem0.80596.9872
hydrogen peroxidePubChem0.78734.0147
hydron diphosphatePubChem0.778391.981
Na(+)PubChem0.76322.9898
acetatePubChem0.74259.044
hydride acetatePubChem0.74261.0599
uracilPubChem0.716112.087