Rv1160

Tuberculist information
Gene namemutT2
Protein functionProbable mutator protein MutT2 (7,8-dihydro-8-oxoguanine-triphosphatase) (8-oxo-dGTPase)
Functional category(tuberculist)information pathways
Gene location(kb)1286.59
Molecular mass(da)15160.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 141
	  		  	1    MLNQIVVAGAIVRGCTVLVAQRVRPPELAGRWELPGGKVAAGETERAALARELAEELGLE   60
			  	61   VADLAVGDRVGDDIALNGTTTLRAYRVHLLGGEPRARDHRALCWVTAAELHDVDWVPADR  120
			  	121  GWIADLARTLNGSAADVHRRC

Known structures in the PDB
No Known structures
1 15 29 43 57 71 85 99 113 127 141 Range: 3 to 129  |  Coverage: 89% NUDIX Range: 4 to 128  |  Coverage: 87% 1 Range: 1 to 141  |  Coverage: 99% 1
Number of amino acids : 141
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
NUDIXPF002933-129
Mtb Structural Proteome models
Model Number1
Model nameRv1160
Template1IRY    APDBCREDO
Template coverage5_129
Template Identity(%)27.2
Model coverage(%)87.9
Normalized DOPE score0.276

Structure Models from Chopin
Model Number1
Profiled.113.1.1 - 3.90.79.10
Click for model details
zscore20.62
Residue begin1
Residue end141
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1160Gene nameConfidence Score
Rv3589mutY0.992
Rv3589mutY0.992
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
magnesiumPubChem0.84324.305