Rv1848

Tuberculist information
Gene nameureA
Protein functionUrease gamma subunit UreA (urea amidohydrolase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2097.35
Molecular mass(da)11089.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 100
	  		  	1    MRLTPHEQERLLLSYAAELARRRRARGLRLNHPEAIAVIADHILEGARDGRTVAELMASG   60
			  	61   REVLGRDDVMEGVPEMLAEVQVEATFPDGTKLVTVHQPIA

Known structures in the PDB
PDB ID2FVH
Total residue count360
Number of chains3
MethodX-RAY
Resolution1.8
1 11 21 31 41 51 61 71 81 91 101 Range: 1 to 99  |  Coverage: 98% Urease_gamma Range: 2 to 100  |  Coverage: 98% 1 Range: 2 to 100  |  Coverage: 98% 2 Range: 1 to 100  |  Coverage: 99% 1
Number of amino acids : 100
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Urease_gammaPF005471-99
Mtb Structural Proteome models
Model Number1
Model nameRv1848_2fvh_A
Template2FVH    APDBCREDO
Template coverage2_100
Template Identity(%)100.0
Model coverage(%)98.0
Normalized DOPE score-1.875

Model Number2
Model nameRv1848
Template2FVH    APDBCREDO
Template coverage2_100
Template Identity(%)100.0
Model coverage(%)98.0
Normalized DOPE score-1.496

Structure Models from Chopin
Model Number1
Profiled.8.1.1
Click for model details
zscore29.74
Residue begin1
Residue end100
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1848Gene nameConfidence Score
Rv1849ureB0.999
Rv1850ureC0.999
Rv1850ureC0.999
Rv1851ureF0.999
Rv1852ureG0.999
Rv1853ureD0.987
Rv0440groEL20.969
Rv0667rpoB0.967
Rv0667rpoB0.967
Rv0667rpoB0.967
Rv0667rpoB0.967
Rv0667rpoB0.967
Rv0667rpoB0.967
Rv0350dnaK0.966
Rv2678chemE0.966
Rv2343cdnaG0.964
Rv2343cdnaG0.964
Rv2343cdnaG0.964
Rv2343cdnaG0.964
Rv2343cdnaG0.964
Rv1001arcA0.963
Rv3417cgroEL10.959
Rv0773cggtA0.956
Rv2856nicT0.942
Rv2399ccysT0.925
Rv1436gap0.924
Rv1436gap0.924
Rv2394ggtB0.923
Rv3588ccanB0.923
Rv2462ctig0.92
Rv2462ctig0.92
Rv2462ctig0.92
Rv3313cadd0.919
Rv3914trxC0.915
Rv2976cung0.905
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
ammoniaPubChem0.94317.0305
carbon dioxidePubChem0.91744.0095
hydroxyl radicalsPubChem0.917.0073
urea solutionPubChem0.960.0553
nickelPubChem0.87758.6934
chlorine dioxidePubChem0.79367.4518
acetohydroxamic acidPubChem0.78575.0666
CHEBI:618144PubChem0.77358.451