Rv1850

Tuberculist information
Gene nameureC
Protein functionUrease alpha subunit UreC (urea amidohydrolase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2097.96
Molecular mass(da)60825.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 577
	  		  	1    MARLSRERYAQLYGPTTGDRIRLADTNLLVEVTEDRCGGPGLAGDEAVFGGGKVLRESMG   60
			  	61   QGRASRADGAPDTVITGAVIIDYWGIIKADIGIRDGRIVGIGKAGNPDIMTGVHRDLVVG  120
			  	121  PSTEIISGNRRIVTAGTVDCHVHLICPQIIVEALAAGTTTIIGGGTGPAEGTKATTVTPG  180
			  	181  EWHLARMLESLDGWPVNFALLGKGNTVNPDALWEQLRGGASGFKLHEDWGSTPAAIDTCL  240
			  	241  AVADVAGVQVALHSDTLNETGFVEDTIGAIAGRSIHAYHTEGAGGGHAPDIITVAAQPNV  300
			  	301  LPSSTNPTRPHTVNTLDEHLDMLMVCHHLNPRIPEDLAFAESRIRPSTIAAEDVLHDMGA  360
			  	361  ISMIGSDSQAMGRVGEVVLRTWQTAHVMKARRGALEGDPSGSQAADNNRVRRYIAKYTIC  420
			  	421  PAIAHGMDHLIGSVEVGKLADLVLWEPAFFGVRPHVVLKGGAIAWAAMGDANASIPTPQP  480
			  	481  VLPRPMFGAAAATAAATSVHFVAPQSIDARLADRLAVNRGLAPVADVRAVGKTDLPLNDA  540
			  	541  LPSIEVDPDTFTVRIDGQVWQPQPAAELPMTQRYFLF

Known structures in the PDB
No Known structures
1 58 115 172 229 286 343 400 457 514 571 Range: 2 to 126  |  Coverage: 21% Urease_alpha Range: 132 to 446  |  Coverage: 54% Amidohydro_1 Range: 2 to 577  |  Coverage: 99% 1 Range: 134 to 438  |  Coverage: 52% 1 Range: 135 to 558  |  Coverage: 73% 2
Number of amino acids : 577
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Urease_alphaPF004492-126
Amidohydro_1PF01979132-446
Mtb Structural Proteome models
Model Number1
Model nameRv1850
Template1EJX    CPDBCREDO
Template coverage1002_1567
Template Identity(%)60.9
Model coverage(%)99.7
Normalized DOPE score-0.682

Structure Models from Chopin
Model Number1
Profilec.1.9.6
Click for model details
zscore35.07
Residue begin134
Residue end438
Model Number2
Profilec.1.9.6
Click for model details
zscore24.29
Residue begin135
Residue end558
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1850Gene nameConfidence Score
Rv1848ureA0.999
Rv1849ureB0.999
Rv1851ureF0.999
Rv1852ureG0.999
Rv1853ureD0.979
Rv2856nicT0.939
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
DrugBank IDDrug Name
DB00551DrugBankAcetohydroxamic Acid
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
ammoniaPubChem0.97817.0305
nickelPubChem0.97658.6934
urea solutionPubChem0.95360.0553
carbon dioxidePubChem0.94244.0095
kanamycinPubChem0.942484.499
acetohydroxamic acidPubChem0.93175.0666
hydroxyl radicalsPubChem0.91317.0073
omeprazolePubChem0.85345.416
lansoprazolePubChem0.843369.361
sulphurPubChem0.79334.0809
flurofamidePubChem0.768217.137
NiCl2PubChem0.756129.599
nitratePubChem0.75662.0049
esculinPubChem0.736340.282
butylparabenPubChem0.735194.227
rabeprazolePubChem0.73359.443
xylosePubChem0.72150.13
N(6)-carboxy-L-lysinePubChem0.712190.197