Rv1852

Tuberculist information
Gene nameureG
Protein functionUrease accessory protein UreG
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2100.34
Molecular mass(da)23348.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 224
	  		  	1    MATHSHPHSHTVPARPRRVRKPGEPLRIGVGGPVGSGKTALVAALCRQLRGELSLAVLTN   60
			  	61   DIYTTEDADFLRTHAVLPDDRIAAVQTGGCPHTAIRDDITANLDAIDELMAAHDALDLIL  120
			  	121  VESGGDNLTATFSSGLVDAQIFVIDVAGGDKVPRKGGPGVTYSDLLVVNKTDLAALVGAD  180
			  	181  LAVMARDADAVRDGRPTVLQSLTEDPAASDVVAWVRSQLAADGV

Known structures in the PDB
No Known structures
1 23 45 67 89 111 133 155 177 199 221 Range: 26 to 199  |  Coverage: 77% cobW Range: 7 to 220  |  Coverage: 95% 1 Range: 1 to 224  |  Coverage: 99% 1
Number of amino acids : 224
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
cobWPF0249226-199
Mtb Structural Proteome models
Model Number1
Model nameRv1852
Template2HF9    APDBCREDO
Template coverage15_218
Template Identity(%)25.5
Model coverage(%)95.1
Normalized DOPE score-0.708

Structure Models from Chopin
Model Number1
Profilec.37.1.6 - 3.40.50.300
Click for model details
zscore8.35
Residue begin1
Residue end224
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1852Gene nameConfidence Score
Rv1848ureA0.999
Rv1849ureB0.999
Rv1850ureC0.999
Rv1850ureC0.999
Rv1851ureF0.999
Rv1853ureD0.989
Rv2856nicT0.952
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
ammoniaPubChem0.94217.0305
carbon dioxidePubChem0.90944.0095
urea solutionPubChem0.960.0553
hydroxyl radicalsPubChem0.917.0073
nickelPubChem0.84558.6934
zincPubChem0.865.409