Rv1436

Tuberculist information
Gene namegap
Protein functionProbable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1613.31
Molecular mass(da)35923.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 339
	  		  	1    VTVRVGINGFGRIGRNFYRALLAQQEQGTADVEVVAANDITDNSTLAHLLKFDSILGRLP   60
			  	61   CDVGLEGDDTIVVGRAKIKALAVREGPAALPWGDLGVDVVVESTGLFTNAAKAKGHLDAG  120
			  	121  AKKVIISAPATDEDITIVLGVNDDKYDGSQNIISNASCTTNCLAPLAKVLDDEFGIVKGL  180
			  	181  MTTIHAYTQDQNLQDGPHKDLRRARAAALNIVPTSTGAAKAIGLVMPQLKGKLDGYALRV  240
			  	241  PIPTGSVTDLTVDLSTRASVDEINAAFKAAAEGRLKGILKYYDAPIVSSDIVTDPHSSIF  300
			  	301  DSGLTKVIDDQAKVVSWYDNEWGYSNRLVDLVTLVGKSL

Known structures in the PDB
No Known structures
1 34 67 100 133 166 199 232 265 298 331 Range: 3 to 158  |  Coverage: 45% Gp_dh_N Range: 163 to 318  |  Coverage: 45% Gp_dh_C Range: 3 to 338  |  Coverage: 98% 1 Range: 163 to 318  |  Coverage: 45% 1
Number of amino acids : 339
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Gp_dh_NPF000443-158
Gp_dh_CPF02800163-318
Mtb Structural Proteome models
Model Number1
Model nameRv1436
Template1VC2    APDBCREDO
Template coverage1_329
Template Identity(%)61.1
Model coverage(%)98.8
Normalized DOPE score-0.767

Structure Models from Chopin
Model Number1
Profiled.81.1.1
Click for model details
zscore8.05
Residue begin163
Residue end318
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1436Gene nameConfidence Score
Rv1437pgk0.999
Rv1438tpi0.999
Rv0363cfba0.999
Rv1617pykA0.998
Rv1617pykA0.998
Rv1449ctkt0.998
Rv1449ctkt0.998
Rv1449ctkt0.998
Rv1023eno0.995
Rv1023eno0.995
Rv0946cpgi0.993
Rv0350dnaK0.985
Rv1448ctal0.972
Rv0489gpm10.966
Rv3588ccanB0.964
Rv3010cpfkA0.96
Rv3846sodA0.941
Rv3846sodA0.941
Rv1240mdh0.938
Rv1240mdh0.938
Rv3914trxC0.936
Rv0440groEL20.929
Rv1848ureA0.924
Rv0684fusA10.921
Rv0684fusA10.921
Rv0684fusA10.921
Rv0684fusA10.921
Rv0684fusA10.921
Rv1408rpe0.915
Rv0733adk0.913
Rv0408pta0.913
Rv0408pta0.913
Rv0408pta0.913
Rv0952sucD0.91
Rv0952sucD0.91
Rv2678chemE0.908
Rv1420uvrC0.904
Rv1420uvrC0.904
Rv1420uvrC0.904
Rv1420uvrC0.904
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
D-glyceraldehyde-3-phosphatePubChem0.998170.058
NAD+PubChem0.993663.425
glyceraldehyde-3-phosphatePubChem0.992170.058
phosphatePubChem0.98896.9872
1,3-diphosphoglyceratePubChem0.977266.037
1,3-bisphosphoglyceratePubChem0.975266.037
3-phosphoglyceratePubChem0.963186.057
reduced nicotinamide adenine dinucleotidePubChem0.962665.441
fructose 1,6-bisphosphatePubChem0.962340.116
dihydroxyacetone phosphatePubChem0.941170.058
pyruvic acidPubChem0.93788.0621
2-keto-3-deoxy-6-phosphogluconatePubChem0.927258.12
glycerolPubChem0.92692.0938
adenosine triphosphatePubChem0.922507.181
H(+)PubChem0.922.01588
deuteriumPubChem0.9162.01588
1,3-bisphospho-d-glyceratePubChem0.909266.037
D-fructose 1,6-bisphosphatePubChem0.902550.183
adenosine diphosphatePubChem0.9427.201
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
protiumPubChem0.92.01576
3-deoxy-D-erythro-hex-2-ulosonic acid 6-phosphatePubChem0.9258.12
AEBSFPubChem0.813203.234
hydron sulfatePubChem0.797196.157
sulfatePubChem0.79796.0626
NADPPubChem0.784744.413
magnesiumPubChem0.75124.305