Rv0946c

Tuberculist information
Gene namepgi
Protein functionProbable glucose-6-phosphate isomerase Pgi (GPI) (phosphoglucose isomerase) (phosphohexose isomerase) (phi)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1055.02
Molecular mass(da)59974.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 553
	  		  	1    MTSAPIPDITATPAWDALRRHHDQIGNTHLRQFFADDPGRGRELTVSVGDLYIDYSKHRV   60
			  	61   TRETLALLIDLARTAHLEERRDQMFAGVHINTSEDRAVLHTALRLPRDAELVVDGQDVVT  120
			  	121  DVHAVLDAMGAFTDRLRSGEWTGATGKRISTVVNIGIGGSDLGPVMVYQALRHYADAGIS  180
			  	181  ARFVSNVDPADLIATLADLDPATTLFIVASKTFSTLETLTNATAARRWLTDALGDAAVSR  240
			  	241  HFVAVSTNKRLVDDFGINTDNMFGFWDWVGGRYSVDSAIGLSLMTVIGRDAFADFLAGFH  300
			  	301  IIDRHFATAPLESNAPVLLGLIGLWYSNFFGAQSRTVLPYSNDLSRFPAYLQQLTMESNG  360
			  	361  KSTRADGSPVSADTGEIFWGEPGTNGQHAFYQLLHQGTRLVPADFIGFAQPLDDLPTAEG  420
			  	421  TGSMHDLLMSNFFAQTQVLAFGKTAEEIAADGTPAHVVAHKVMPGNRPSTSILASRLTPS  480
			  	481  VLGQLIALYEHQVFTEGVVWGIDSFDQWGVELGKTQAKALLPVITGAGSPPPQSDSSTDG  540
			  	541  LVRRYRTERGRAG

Known structures in the PDB
PDB ID2WU8
Total residue count549
Number of chains1
MethodX-RAY
Resolution2.25
1 56 111 166 221 276 331 386 441 496 551 Range: 54 to 542  |  Coverage: 88% PGI Range: 7 to 555  |  Coverage: 99% 1 Range: 13 to 547  |  Coverage: 96% 2 Range: 4 to 553  |  Coverage: 99% 1
Number of amino acids : 553
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
PGIPF0034254-542
Mtb Structural Proteome models
Model Number1
Model nameRv0946c_2wu8_A
Template2WU8    APDBCREDO
Template coverage7_555
Template Identity(%)100.0
Model coverage(%)99.1
Normalized DOPE score-1.633

Model Number2
Model nameRv0946c
Template1T10    APDBCREDO
Template coverage54_601
Template Identity(%)49.9
Model coverage(%)96.6
Normalized DOPE score-1.039

Structure Models from Chopin
Model Number1
Profilec.80.1.2
Click for model details
zscore88.48
Residue begin4
Residue end553
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0946cGene nameConfidence Score
Rv1449ctkt0.997
Rv3068cpgmA0.997
Rv1449ctkt0.997
Rv3068cpgmA0.997
Rv1449ctkt0.997
Rv3068cpgmA0.997
Rv1617pykA0.997
Rv1617pykA0.997
Rv3010cpfkA0.997
Rv1448ctal0.997
Rv3068cpgmA0.997
Rv1438tpi0.996
Rv3255cmanA0.996
Rv1447czwf20.995
Rv1447czwf20.995
Rv1436gap0.993
Rv1023eno0.993
Rv1436gap0.993
Rv0363cfba0.993
Rv1121zwf10.993
Rv1121zwf10.993
Rv1023eno0.993
Rv3257cpmmA0.99
Rv3257cpmmA0.99
Rv3257cpmmA0.99
Rv3257cpmmA0.99
Rv0489gpm10.987
Rv1437pgk0.985
Rv2213pepB0.979
Rv2213pepB0.979
Rv1240mdh0.974
Rv1240mdh0.974
Rv0733adk0.972
Rv1099cglpX0.959
Rv0650Rv06500.955
Rv2029cpfkB0.951
Rv1213glgC0.941
Rv1213glgC0.941
Rv3436cglmS0.933
Rv3436cglmS0.933
Rv1844cgnd10.932
Rv3846sodA0.932
Rv3846sodA0.932
Rv1844cgnd10.932
Rv1326cglgB0.93
Rv1326cglgB0.93
Rv1326cglgB0.93
Rv2702ppgK0.925
Rv1408rpe0.922
Rv0409ackA0.914
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
glucose-6-phosphatePubChem0.994260.136
phosphatePubChem0.99296.9872
D-fructose 6-phosphatePubChem0.992260.136
fructose 6-phosphatePubChem0.99260.136
D-fructose-6-phosphatePubChem0.988260.136
sulfatePubChem0.9896.0626
alpha-D-glucose 6-phosphatePubChem0.979260.136
6-phosphogluconatePubChem0.979276.135
hydron sulfatePubChem0.978196.157
glucose-6-PPubChem0.964260.136
fructose 1,6-bisphosphatePubChem0.953340.116
mannose-6-phosphatePubChem0.948260.136
mannose 6-phosphatePubChem0.947260.136
erythrose 4-phosphatePubChem0.944200.084
mannitol-1-phosphatePubChem0.94262.152
sorbitol-6-phosphatePubChem0.93262.152
adenosine triphosphatePubChem0.914507.181
deuteriumPubChem0.9092.01588
H(+)PubChem0.9092.01588
protiumPubChem0.9032.01576
glycerolPubChem0.992.0938
adenosine diphosphatePubChem0.9427.201
D-fructose 1,6-bisphosphatePubChem0.9550.183
hydroxyl radicalsPubChem0.917.0073
D-erythronate-4-phosphatePubChem0.816215.075
acetatePubChem0.81659.044
calciumPubChem0.81240.078
fructosePubChem0.801180.156
Pa5PubChem0.795246.109
2-mercaptoethanolPubChem0.78778.1334
A5PPubChem0.786232.126
D-glucose-6-phosphatePubChem0.784413.462
polyribosylribitolphosphatePubChem0.766232.126
galactosePubChem0.748180.156
hexosePubChem0.744180.156
chloridePubChem0.74335.453
Na(+)PubChem0.73122.9898
selenomethioninePubChem0.709196.106
SeMetPubChem0.709196.106
isopropanolPubChem0.70660.095
2-(N-morpholino)ethanesulfonic acidPubChem0.706195.237
diethylene glycolPubChem0.704106.12
tetraethylene glycolPubChem0.704194.226
C03251PubChem0.7298.198
galactose-6-phosphatePubChem0.7298.198
DB02093PubChem0.7261.124
Aids236254PubChem0.7261.124