Rv2702

Tuberculist information
Gene nameppgK
Protein functionPolyphosphate glucokinase PpgK (polyphosphate-glucose phosphotransferase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3016.86
Molecular mass(da)27429.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 265
	  		  	1    MTSTGPETSETPGATTQRHGFGIDVGGSGIKGGIVDLDTGQLIGDRIKLLTPQPATPLAV   60
			  	61   AKTIAEVVNGFGWRGPLGVTYPGVVTHGVVRTAANVDKSWIGTNARDTIGAELGGQQVTI  120
			  	121  LNDADAAGLAETRYGAGKNNPGLVVLLTFGTGIGSAVIHNGTLIPNTEFGHLEVGGKEAE  180
			  	181  ERAASSVKEKNDWTYPKWAKQVIRVLIAIENAIWPDLFIAGGGISRKADKWVPLLENRTP  240
			  	241  VVPAALQNTAGIVGAAMASVADTTH

Known structures in the PDB
No Known structures
1 27 53 79 105 131 157 183 209 235 261 Range: 22 to 186  |  Coverage: 61% ROK Range: 18 to 261  |  Coverage: 91% 1 Range: 3 to 177  |  Coverage: 65% 1
Number of amino acids : 265
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ROKPF0048022-186
Mtb Structural Proteome models
Model Number1
Model nameRv2702
Template1WOQ    APDBCREDO
Template coverage12_262
Template Identity(%)50.4
Model coverage(%)91.7
Normalized DOPE score-0.924

Structure Models from Chopin
Model Number1
Profilec.121.1.1 - 3.40.1400.10
Click for model details
zscore4.08
Residue begin3
Residue end177
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2702Gene nameConfidence Score
Rv3068cpgmA0.958
Rv3068cpgmA0.958
Rv3068cpgmA0.958
Rv3068cpgmA0.958
Rv0946cpgi0.925
Rv3257cpmmA0.904
Rv3257cpmmA0.904
Rv3257cpmmA0.904
Rv3257cpmmA0.904
Rv0650Rv06500.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
glucose-6-phosphatePubChem0.922260.136
beta-D-glucosePubChem0.9180.156
alpha-D-glucose 6-phosphatePubChem0.9260.136
galactosePubChem0.9180.156
alpha-D-glucosePubChem0.9198.171
glucose-6-PPubChem0.9260.136