Rv3257c

Tuberculist information
Gene namepmmA
Protein functionProbable phosphomannomutase PmmA (PMM) (phosphomannose mutase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3637.31
Molecular mass(da)49041
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 465
	  		  	1    MSWPAAAVDRVIKAYDVRGLVGEEIDESLVTDLGAAFARLMRTEDARPVVIGHDMRDSSP   60
			  	61   SLADAFAAGVTGQGLDVVRVGLASTDQLYFASGLLDCPGAMFTASHNPAAYNGIKMCRAA  120
			  	121  AKPVGADTGLTAIRDDLIAGVARYDGTPGTIADQDVLVDYGAFLRSLVDTSGLRPLRVAV  180
			  	181  DAGNGMAGHTAPAVLGVIDSITLLPSYFELDGSFPNHEANPLDPANLVDLQAYVRDTGAD  240
			  	241  IGLAFDGDADRCFVVDERGQPVSPSTVTALVAARELNREIGATIIHNVITSRAVPELVAE  300
			  	301  RGGTPLRSRVGHSYIKALMAETGAIFGGEHSAHYYFRDFWGADSGMLAALHVLAALGEQS  360
			  	361  RPLSELTADYQRYESSGEINFTVVDSSACVEAVLKSFGNRIVSIDHLDGVTVDLGDDSWF  420
			  	421  NLRSSNTEPLLRLNVEGRSVGDVDAVVRQVSAEIAAQSAHAKAGP

Known structures in the PDB
No Known structures
1 47 93 139 185 231 277 323 369 415 461 Range: 9 to 139  |  Coverage: 27% PGM_PMM_I Range: 158 to 259  |  Coverage: 21% PGM_PMM_II Range: 264 to 373  |  Coverage: 23% PGM_PMM_III Range: 378 to 455  |  Coverage: 16% PGM_PMM_IV Range: 10 to 456  |  Coverage: 95% 1 Range: 1 to 465  |  Coverage: 99% 1 Range: 9 to 139  |  Coverage: 27% 2 Range: 378 to 455  |  Coverage: 16% 3 Range: 358 to 465  |  Coverage: 23% 4 Range: 158 to 259  |  Coverage: 21% 5
Number of amino acids : 465
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
PGM_PMM_IPF028789-139
PGM_PMM_IIPF02879158-259
PGM_PMM_IIIPF02880264-373
PGM_PMM_IVPF00408378-455
Mtb Structural Proteome models
Model Number1
Model nameRv3257c
Template1P5D    XPDBCREDO
Template coverage12_454
Template Identity(%)33.5
Model coverage(%)95.9
Normalized DOPE score-0.696

Structure Models from Chopin
Model Number1
Profilec.84.1.1, d.129.2.1 - 3.30.310.50, 3.40.120.10
Click for model details
zscore60.61
Residue begin1
Residue end465
Model Number2
Profile3.40.120.10
Click for model details
zscore21.64
Residue begin9
Residue end139
Model Number3
Profile3.30.310.50
Click for model details
zscore14.38
Residue begin378
Residue end455
Model Number4
Profile3.30.310.50
Click for model details
zscore13.26
Residue begin358
Residue end465
Model Number5
Profilec.84.1.1
Click for model details
zscore6.96
Residue begin158
Residue end259
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3257cGene nameConfidence Score
Rv3255cmanA0.998
Rv0993galU0.995
Rv3264cmanB0.992
Rv3264cmanB0.992
Rv0946cpgi0.99
Rv0334rmlA0.989
Rv1213glgC0.967
Rv1213glgC0.967
Rv1449ctkt0.941
Rv1449ctkt0.941
Rv1449ctkt0.941
Rv0650Rv06500.929
Rv1328glgP0.924
Rv1328glgP0.924
Rv0619galTb0.905
Rv2702ppgK0.904
Rv1017cprsA0.904
Rv1017cprsA0.904
Rv2465crpiB0.902
Rv3068cpgmA0.901
Rv3068cpgmA0.901
Rv3068cpgmA0.901
Rv3068cpgmA0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
glucose-1-phosphatePubChem0.988260.136
glucose-6-phosphatePubChem0.985260.136
mannose-6-phosphatePubChem0.975260.136
GDP-mannosePubChem0.971605.341
mannose 6-phosphatePubChem0.969260.136
mannosePubChem0.953180.156
alpha-D-glucose 6-phosphatePubChem0.951260.136
alpha-d-mannose-1-phosphatePubChem0.951260.136
galactosePubChem0.95180.156
D-ribose 5-phosphatePubChem0.9230.11
H(+)PubChem0.92.01588
deuteriumPubChem0.92.01588
carboxymethylcellulosePubChem0.9240.208
adenosine triphosphatePubChem0.9507.181
D-fructose-6-phosphatePubChem0.9260.136
D-fructose 6-phosphatePubChem0.9260.136
protiumPubChem0.92.01576
guanosine triphosphatePubChem0.9523.18
adenosine diphosphatePubChem0.9427.201
pyrophosphatePubChem0.9177.975
polymannosePubChem0.9180.156
mannose-1-phosphatePubChem0.841260.136