Rv3255c

Tuberculist information
Gene namemanA
Protein functionProbable mannose-6-phosphate isomerase ManA (phosphomannose isomerase) (phosphomannoisomerase) (PMI) (phosphohexoisomerase) (phosphohexomutase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3635.04
Molecular mass(da)43339.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 408
	  		  	1    VELLRGALRTYAWGSRTAIAEFTGRPVPAAHPEAELWFGAHPGDPAWLQTPHGQTSLLEA   60
			  	61   LVADPEGQLGSASRARFGDVLPFLVKVLAADEPLSLQAHPSAEQAVEGYLREERMGIPVS  120
			  	121  SPVRNYRDTSHKPELLVALQPFEALAGFREAARTTELLRALAVSDLDPFIDLLSEGSDAD  180
			  	181  GLRALFTTWITAPQPDIDVLVPAVLDGAIQYVSSGATEFGAEAKTVLELGERYPGDAGVL  240
			  	241  AALLLNRISLAPGEAIFLPAGNLHAYVRGFGVEVMANSDNVLRGGLTPKHVDVPELLRVL  300
			  	301  DFAPTPKARLRPPIRREGLGLVFETPTDEFAATLLVLDGDHLGHEVDASSGHDGPQILLC  360
			  	361  TEGSATVHGKCGSLTLQRGTAAWVAADDGPIRLTAGQPAKLFRATVGL

Known structures in the PDB
No Known structures
1 41 81 121 161 201 241 281 321 361 401 Range: 1 to 370  |  Coverage: 90% PMI_typeI Range: 9 to 395  |  Coverage: 94% 1 Range: 1 to 408  |  Coverage: 99% 1
Number of amino acids : 408
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
PMI_typeIPF012381-370
Mtb Structural Proteome models
Model Number1
Model nameRv3255c
Template1PMI    APDBCREDO
Template coverage14_423
Template Identity(%)33.1
Model coverage(%)94.6
Normalized DOPE score0.23

Structure Models from Chopin
Model Number1
Profileb.82.1.3
Click for model details
zscore22.33
Residue begin1
Residue end408
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3255cGene nameConfidence Score
Rv3257cpmmA0.998
Rv3257cpmmA0.998
Rv3257cpmmA0.998
Rv3257cpmmA0.998
Rv0946cpgi0.996
Rv3308pmmB0.989
Rv3308pmmB0.989
Rv3308pmmB0.989
Rv3308pmmB0.989
Rv3436cglmS0.939
Rv3436cglmS0.939
Rv3264cmanB0.93
Rv3264cmanB0.93
Rv3010cpfkA0.907
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
D-fructose 6-phosphatePubChem0.979260.136
mannose-6-phosphatePubChem0.976260.136
mannose 6-phosphatePubChem0.971260.136
D-fructose-6-phosphatePubChem0.97260.136
glucose-6-phosphatePubChem0.969260.136
glucose-1-phosphatePubChem0.926260.136
alpha-d-mannose-1-phosphatePubChem0.922260.136
glucose-6-PPubChem0.92260.136
zincPubChem0.84565.409
CDGPubChem0.718264.229
fructose 6-phosphatePubChem0.703260.136