Rv3308

Tuberculist information
Gene namepmmB
Protein functionProbable phosphomannomutase PmmB (phosphomannose mutase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3694.86
Molecular mass(da)56163.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 534
	  		  	1    VTPENWIAHDPDPQTAAELAACGPDELKARFSRPLAFGTAGLRGHLRGGPDAMNLAVVLR   60
			  	61   ATWAVARVLTDRGLAGSPVIVGRDARHGSPAFAAAAAEVLAAAGFSVLLLPDPAPTPVVA  120
			  	121  FAVRHTGAAAGIQITASHNPATDNGYKVYVDGGLQLLAPTDRQIEAAMATAPPADQIARK  180
			  	181  TVNPSENRASDLIDRYIQRAAGVRRCAGSVRVALTPLHGVGGAMAVETLRRAGFTEVHTV  240
			  	241  ATQFAPNPDFPTVTLPNPEEPGATDALLTLATDVDADVAIALDPDADRCAVGIPTVSGWR  300
			  	301  MLSGDETGWLLGDYILSQTDDRASPPETRVVASTVVSSRMLAAIAAHHAAVHVETLTGFK  360
			  	361  WLARADANLPGTLVYAYEEAIGHCVDPTAVRDKDGISAAVLVCDLVAALKGQGRSVTDAL  420
			  	421  DELARCYGVHEVAALSRPVSGAVETTDLMRRLREDPPRRLAGFPATVTDIGDTLILTGGD  480
			  	481  DNMLVRVAVRPSGTEPKLKCYLEIRCAVTGDLPAARQLVRARIDELSASVRRWW

Known structures in the PDB
No Known structures
1 54 107 160 213 266 319 372 425 478 531 Range: 34 to 174  |  Coverage: 26% PGM_PMM_I Range: 190 to 297  |  Coverage: 20% PGM_PMM_II Range: 303 to 427  |  Coverage: 23% PGM_PMM_III Range: 448 to 507  |  Coverage: 11% PGM_PMM_IV Range: 17 to 530  |  Coverage: 96% 1 Range: 19 to 534  |  Coverage: 96% 1 Range: 34 to 174  |  Coverage: 26% 2 Range: 430 to 534  |  Coverage: 19% 3 Range: 303 to 427  |  Coverage: 23% 4
Number of amino acids : 534
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
PGM_PMM_IPF0287834-174
PGM_PMM_IIPF02879190-297
PGM_PMM_IIIPF02880303-427
PGM_PMM_IVPF00408448-507
Mtb Structural Proteome models
Model Number1
Model nameRv3308
Template2FUV    APDBCREDO
Template coverage24_542
Template Identity(%)24.5
Model coverage(%)96.1
Normalized DOPE score0.157

Structure Models from Chopin
Model Number1
Profilec.84.1.1, d.129.2.1 - 3.30.310.50, 3.40.120.10
Click for model details
zscore54.35
Residue begin19
Residue end534
Model Number2
Profile3.40.120.10
Click for model details
zscore16.77
Residue begin34
Residue end174
Model Number3
Profile3.30.310.50
Click for model details
zscore10.05
Residue begin430
Residue end534
Model Number4
Profilec.84.1.1
Click for model details
zscore4.01
Residue begin303
Residue end427
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3308Gene nameConfidence Score
Rv3255cmanA0.989
Rv3264cmanB0.983
Rv3264cmanB0.983
Rv0478deoC0.968
Rv0993galU0.952
Rv3307deoD0.911
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
glucose-1-phosphatePubChem0.963260.136
glucose-6-phosphatePubChem0.954260.136
D-fructose-6-phosphatePubChem0.935260.136
D-fructose 6-phosphatePubChem0.934260.136
galactosePubChem0.932180.156
carboxymethylcellulosePubChem0.901240.208
mannosePubChem0.901180.156
mannose-6-phosphatePubChem0.9260.136
adenosine triphosphatePubChem0.9507.181
alpha-d-mannose-1-phosphatePubChem0.9260.136
mannose 6-phosphatePubChem0.9260.136
guanosine triphosphatePubChem0.9523.18
adenosine diphosphatePubChem0.9427.201
pyrophosphatePubChem0.9177.975
polymannosePubChem0.9180.156
GDP-mannosePubChem0.9605.341
protiumPubChem0.92.01576
deuteriumPubChem0.92.01588
H(+)PubChem0.92.01588