Rv3264c

Tuberculist information
Gene namemanB
Protein functionD-alpha-D-mannose-1-phosphate guanylyltransferase ManB (D-alpha-D-heptose-1-phosphate guanylyltransferase)
Functional category(tuberculist)cell wall and cell processes
Gene location(kb)3644.9
Molecular mass(da)37839
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 359
	  		  	1    LATHQVDAVVLVGGKGTRLRPLTLSAPKPMLPTAGLPFLTHLLSRIAAAGIEHVILGTSY   60
			  	61   KPAVFEAEFGDGSALGLQIEYVTEEHPLGTGGGIANVAGKLRNDTAMVFNGDVLSGADLA  120
			  	121  QLLDFHRSNRADVTLQLVRVGDPRAFGCVPTDEEDRVVAFLEKTEDPPTDQINAGCYVFE  180
			  	181  RNVIDRIPQGREVSVEREVFPALLADGDCKIYGYVDASYWRDMGTPEDFVRGSADLVRGI  240
			  	241  APSPALRGHRGEQLVHDGAAVSPGALLIGGTVVGRGAEIGPGTRLDGAVIFDGVRVEAGC  300
			  	301  VIERSIIGFGARIGPRALIRDGVIGDGADIGARCELLSGARVWPGVFLPDGGIRYSSDV

Known structures in the PDB
No Known structures
1 36 71 106 141 176 211 246 281 316 351 Range: 7 to 239  |  Coverage: 64% NTP_transferase Range: 254 to 287  |  Coverage: 9% Hexapep Range: 287 to 321  |  Coverage: 9% Hexapep Range: 6 to 351  |  Coverage: 96% 1 Range: 2 to 346  |  Coverage: 95% 1 Range: 245 to 354  |  Coverage: 30% 2
Number of amino acids : 359
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
NTP_transferasePF004837-239
HexapepPF00132254-287
HexapepPF00132287-321
Mtb Structural Proteome models
Model Number1
Model nameRv3264c
Template1HV9    APDBCREDO
Template coverage6_341
Template Identity(%)25.6
Model coverage(%)96.1
Normalized DOPE score0.148

Structure Models from Chopin
Model Number1
Profilec.68.1.6 - 3.90.550.10
Click for model details
zscore47.42
Residue begin2
Residue end346
Model Number2
Profileb.81.1.4
Click for model details
zscore11.48
Residue begin245
Residue end354
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3264cGene nameConfidence Score
Rv3257cpmmA0.992
Rv3257cpmmA0.992
Rv3257cpmmA0.992
Rv3257cpmmA0.992
Rv3308pmmB0.983
Rv3308pmmB0.983
Rv3308pmmB0.983
Rv3308pmmB0.983
Rv0112gca0.971
Rv3266crmlD0.97
Rv1511gmdA0.959
Rv3265cwbbL10.948
Rv3784Rv37840.941
Rv3255cmanA0.93
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
glucose-1-phosphatePubChem0.981260.136
GDP-mannosePubChem0.969605.341
alpha-d-mannose-1-phosphatePubChem0.9260.136