Rv3784

Tuberculist information
Gene nameRv3784
Protein functionPossible dTDP-glucose 4,6-dehydratase
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)4230.26
Molecular mass(da)36305.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 326
	  		  	1    MEILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDG   60
			  	61   QTIDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYVSTC  120
			  	121  EVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFGV  180
			  	181  RQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRGQAI  240
			  	241  NFASGKDTRVRDIVEYVADKFGARIEHRDARPGEVQRFPADISLAKSIGFQPQVEIWDGI  300
			  	301  DRYINWAKDQPQYPYEQDGFSGSSVL

Known structures in the PDB
No Known structures
1 33 65 97 129 161 193 225 257 289 321 Range: 3 to 243  |  Coverage: 73% Epimerase Range: 1 to 313  |  Coverage: 95% 1 Range: 1 to 326  |  Coverage: 99% 1
Number of amino acids : 326
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
EpimerasePF013703-243
Mtb Structural Proteome models
Model Number1
Model nameRv3784
Template1KEW    APDBCREDO
Template coverage1_340
Template Identity(%)31.0
Model coverage(%)95.7
Normalized DOPE score-0.969

Structure Models from Chopin
Model Number1
Profilec.2.1.2 - 3.40.50.720
Click for model details
zscore10.56
Residue begin1
Residue end326
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3784Gene nameConfidence Score
Rv0334rmlA0.994
Rv3465rmlC0.994
Rv3264cmanB0.941
Rv3264cmanB0.941
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
deoxythymidine diphosphate-glucosePubChem0.933564.329
dTDP-glucosePubChem0.933564.329
glucose-1-phosphatePubChem0.921260.136
TDP-4-keto-6-deoxy-d-glucosePubChem0.909546.314
dTDP-4-amino-4,6-dideoxy-D-glucosePubChem0.905547.345
deuteriumPubChem0.9012.01588
thymidine triphosphatePubChem0.901482.168
H(+)PubChem0.9012.01588
TDP-alpha-GPubChem0.9564.329
dTDP-4-keto-L-rhamnosePubChem0.9546.314
dTDP-4-dehydro-L-rhamnosePubChem0.9544.298
hydroxyl radicalsPubChem0.917.0073
alpha-ketoglutaratePubChem0.9146.098
glutamatePubChem0.9147.129
protiumPubChem0.92.01576
TDP-FucNPubChem0.9546.337
pyrophosphatePubChem0.9177.975
NAD+PubChem0.756663.425