Rv0334

Tuberculist information
Gene namermlA
Protein functionAlpha-D-glucose-1-phosphate thymidylyltransferase RmlA (dTDP-glucose synthase) (dTDP-glucose pyrophosphorylase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)398.658
Molecular mass(da)31492
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 288
	  		  	1    MRGIILAGGSGTRLYPITMGISKQLLPVYDKPMIYYPLTTLMMAGIRDIQLITTPHDAPG   60
			  	61   FHRLLGDGAHLGVNISYATQDQPDGLAQAFVIGANHIGADSVALVLGDNIFYGPGLGTSL  120
			  	121  KRFQSISGGAIFAYWVANPSAYGVVEFGAEGMALSLEEKPVTPKSNYAVPGLYFYDNDVI  180
			  	181  EIARGLKKSARGEYEITEVNQVYLNQGRLAVEVLARGTAWLDTGTFDSLLDAADFVRTLE  240
			  	241  RRQGLKVSIPEEVAWRMGWIDDEQLVQRARALVKSGYGNYLLELLERN

Known structures in the PDB
No Known structures
1 29 57 85 113 141 169 197 225 253 281 Range: 2 to 239  |  Coverage: 82% NTP_transferase Range: 2 to 286  |  Coverage: 98% 1 Range: 1 to 288  |  Coverage: 99% 1
Number of amino acids : 288
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
NTP_transferasePF004832-239
Mtb Structural Proteome models
Model Number1
Model nameRv0334
Template1H5R    APDBCREDO
Template coverage5_290
Template Identity(%)61.8
Model coverage(%)98.6
Normalized DOPE score-1.157

Structure Models from Chopin
Model Number1
Profilec.68.1.6 - 3.90.550.10
Click for model details
zscore51.6
Residue begin1
Residue end288
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0334Gene nameConfidence Score
Rv3464rmlB0.999
Rv3465rmlC0.998
Rv3266crmlD0.997
Rv3784Rv37840.994
Rv3634cgalE10.993
Rv3257cpmmA0.989
Rv3257cpmmA0.989
Rv3257cpmmA0.989
Rv3257cpmmA0.989
Rv3265cwbbL10.972
Rv3468cRv3468c0.968
Rv3809cglf0.966
Rv3809cglf0.966
Rv0993galU0.963
Rv1512epiA0.946
Rv1511gmdA0.945
Rv0322udgA0.941
Rv0322udgA0.941
Rv0322udgA0.941
Rv1302rfe0.938
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
glucose-1-phosphatePubChem0.997260.136
deoxythymidine diphosphate-glucosePubChem0.996564.329
dTDP-glucosePubChem0.996564.329
thymidine triphosphatePubChem0.986482.168
dTDP-L-rhamnosePubChem0.974548.33
pyrophosphatePubChem0.962177.975
TDP-4-keto-6-deoxy-d-glucosePubChem0.944546.314
protiumPubChem0.92.01576
hydroxyl radicalsPubChem0.917.0073
H(+)PubChem0.92.01588
TDP-alpha-GPubChem0.9564.329
deuteriumPubChem0.92.01588
UDP-glucosePubChem0.889566.302
thymidine diphosphatePubChem0.854402.188
selenomethioninePubChem0.845196.106
rhamnosePubChem0.838164.156
fucosePubChem0.818164.156
thymidylatePubChem0.794322.208
thymidinePubChem0.792242.229
hydron sulfatePubChem0.791196.157
sulfatePubChem0.79196.0626
SeMetPubChem0.784196.106
magnesiumPubChem0.72924.305