Rv3468c

Tuberculist information
Gene nameRv3468c
Protein functionPossible dTDP-glucose 4,6-dehydratase
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3884.98
Molecular mass(da)39482.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 364
	  		  	1    VGTHAATMRVRAGVRSSPLLLHAGTPPTAAAAESGMRTLVTGSSGHLGEALVRTLRARGA   60
			  	61   DIVSLDSRPSRYTNIVGCVSDRALLRDVMAGVEVVFHAAAHHKPQLAFLPRQAFLDTNII  120
			  	121  GTQTVLDAAVAANVRAFVMTSSTTVFGDALTPPADQPAAWIDESVTPIPKNIYGVTKASS  180
			  	181  EDLCQLAHRNDGLACVVLRVARFFVEGDDMPDLYDGRSQDNIKANEYACRRVALEDAVDA  240
			  	241  HLNAAQRAPQLGFGRYLVSATTPFTRDDLTQLRTDAASVFARRVPLAAAVWTQRGWRFPD  300
			  	301  RLDRVYVNSRARRDLNWRPRFDLNAVAARLARGQSVHTPLSQLVGSKAYAHSSYHRGVFA  360
			  	361  PARP

Known structures in the PDB
No Known structures
1 37 73 109 145 181 217 253 289 325 361 Range: 38 to 223  |  Coverage: 50% Epimerase Range: 36 to 355  |  Coverage: 87% 1
Number of amino acids : 364
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
EpimerasePF0137038-223
Mtb Structural Proteome models
Model Number1
Model nameRv3468c
Template1KEW    APDBCREDO
Template coverage1_358
Template Identity(%)20.9
Model coverage(%)87.6
Normalized DOPE score0.11

Structure Models from Chopin
CHOPIN models not available for this query
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3468cGene nameConfidence Score
Rv3465rmlC0.972
Rv0334rmlA0.968
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
dTDP-4-amino-4,6-dideoxy-D-glucosePubChem0.9547.345
H(+)PubChem0.92.01588
glutamatePubChem0.9147.129
dTDP-glucosePubChem0.9564.329
TDP-4-keto-6-deoxy-d-glucosePubChem0.9546.314
protiumPubChem0.92.01576
hydroxyl radicalsPubChem0.917.0073
TDP-FucNPubChem0.9546.337
thymidine triphosphatePubChem0.9482.168
glucose-1-phosphatePubChem0.9260.136
TDP-alpha-GPubChem0.9564.329
deoxythymidine diphosphate-glucosePubChem0.9564.329
dTDP-4-keto-L-rhamnosePubChem0.9546.314
deuteriumPubChem0.92.01588
dTDP-4-dehydro-L-rhamnosePubChem0.9544.298
pyrophosphatePubChem0.9177.975
alpha-ketoglutaratePubChem0.9146.098