Rv1511

Tuberculist information
Gene namegmdA
Protein functionGDP-D-mannose dehydratase GmdA (GDP-mannose 4,6 dehydratase) (GMD)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1703.07
Molecular mass(da)38310.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 340
	  		  	1    VKRALITGITGQDGSYLAELLLAKGYEVHGLIRRASTFNTSRIDHLYVDPHQPGARLFLH   60
			  	61   YGDLIDGTRLVTLLSTIEPDEVYNLAAQSHVRVSFDEPVHTGDTTGMGSMRLLEAVRLSR  120
			  	121  VHCRFYQASSSEMFGASPPPQNELTPFYPRSPYGAAKVYSYWATRNYREAYGLFAVNGIL  180
			  	181  FNHESPRRGETFVTRKITRAVARIKAGIQSEVYMGNLDAVRDWGYAPEYVEGMWRMLQTD  240
			  	241  EPDDFVLATGRGFTVREFARAAFEHAGLDWQQYVKFDQRYLRPTEVDSLIGDATKAAELL  300
			  	301  GWRASVHTDELARIMVDADMAALECEGKPWIDKPMIAGRT

Known structures in the PDB
No Known structures
1 35 69 103 137 171 205 239 273 307 341 Range: 4 to 248  |  Coverage: 71% Epimerase Range: 2 to 327  |  Coverage: 95% 1 Range: 1 to 340  |  Coverage: 99% 1
Number of amino acids : 340
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
EpimerasePF013704-248
Mtb Structural Proteome models
Model Number1
Model nameRv1511
Template1N7H    APDBCREDO
Template coverage29_359
Template Identity(%)60.7
Model coverage(%)95.6
Normalized DOPE score-0.818

Structure Models from Chopin
Model Number1
Profilec.2.1.2 - 3.40.50.720
Click for model details
zscore9.17
Residue begin1
Residue end340
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1511Gene nameConfidence Score
Rv1512epiA0.999
Rv3264cmanB0.959
Rv3264cmanB0.959
Rv0334rmlA0.945
Rv1526cRv1526c0.937
Rv1526cRv1526c0.937
Rv3465rmlC0.934
Rv3266crmlD0.93
Rv0322udgA0.923
Rv0322udgA0.923
Rv0322udgA0.923
Rv1513Rv15130.906
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
GDP-fucosePubChem0.989589.342
GDP-L-fucosePubChem0.982589.342
Guanosine diphosphate-4-keto-6-deoxy-d-mannosePubChem0.981587.326
NADP(H)PubChem0.981745.421
GDP-mannosePubChem0.98605.341
GDRPubChem0.959589.342
NADPPubChem0.949744.413
H(+)PubChem0.9092.01588
deuteriumPubChem0.9082.01588
glucose-1-phosphatePubChem0.902260.136
pyrophosphatePubChem0.9177.975
hydroxyl radicalsPubChem0.917.0073
alpha-d-mannose-1-phosphatePubChem0.9260.136
guanosine triphosphatePubChem0.9523.18
protiumPubChem0.92.01576
guanosine diphosphatePubChem0.822443.201
fucosePubChem0.786164.156