Rv1512

Tuberculist information
Gene nameepiA
Protein functionProbable nucleotide-sugar epimerase EpiA
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1704.09
Molecular mass(da)34537.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 322
	  		  	1    MNAHTSVGPLDRAARVYIAGHRGLVGSALLRTFAGAGFTNLLVRSRAELDLTDRAATFDF   60
			  	61   VLESRPQVVIDAAARVGGILANDTYPADFLSENLQIQVNLLDAAVAARVPRLLFLGSSCI  120
			  	121  YPKLAPQPIPESALLTGPLEPTNDAYAIAKIAGILAVQAVRRQHGLPWISAMPTNLYGPG  180
			  	181  DNFSPSGSHLLPALIRRYDEAKASGAPNVTNWGTGTPRRELLHVDDLASACLYLLEHFDG  240
			  	241  PTHVNVGTGIDHTIGEIAEMVASAVGYSGETRWDPSKPDGTPRKLLDVSVLREAGWRPSI  300
			  	301  ALRDGIEATVAWYREHAGTVRQ

Known structures in the PDB
No Known structures
1 33 65 97 129 161 193 225 257 289 321 Range: 16 to 247  |  Coverage: 71% Epimerase Range: 15 to 316  |  Coverage: 93% 1 Range: 173 to 322  |  Coverage: 46% 1 Range: 1 to 322  |  Coverage: 99% 2
Number of amino acids : 322
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
EpimerasePF0137016-247
Mtb Structural Proteome models
Model Number1
Model nameRv1512
Template1E6U    APDBCREDO
Template coverage5_315
Template Identity(%)55.3
Model coverage(%)93.5
Normalized DOPE score-1.007

Structure Models from Chopin
Model Number1
Profile3.90.25.10
Click for model details
zscore11.82
Residue begin173
Residue end322
Model Number2
Profilec.2.1.2 - 3.40.50.720
Click for model details
zscore11.27
Residue begin1
Residue end322
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1512Gene nameConfidence Score
Rv1511gmdA0.999
Rv0112gca0.966
Rv0334rmlA0.946
Rv3465rmlC0.921
Rv3266crmlD0.919
Rv1513Rv15130.904
Rv1514cRv1514c0.903
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
NADPPubChem0.984744.413
NADP(H)PubChem0.984745.421
GDP-L-fucosePubChem0.983589.342
GDP-fucosePubChem0.982589.342
GDP-mannosePubChem0.98605.341
Guanosine diphosphate-4-keto-6-deoxy-d-mannosePubChem0.973587.326
H(+)PubChem0.9082.01588
deuteriumPubChem0.9072.01588
protiumPubChem0.92.01576
C14830PubChem0.9587.326
hydroxyl radicalsPubChem0.917.0073
GDP-4-dehydro-6-L-deoxygalactosePubChem0.9585.31
fucosePubChem0.783164.156
3-acetyldeoxynivalenolPubChem0.718338.352