Rv0112

Tuberculist information
Gene namegca
Protein functionPossible GDP-mannose 4,6-dehydratase Gca (GDP-D-mannose dehydratase)
Functional category(tuberculist)cell wall and cell processes
Gene location(kb)136.289
Molecular mass(da)35280.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 318
	  		  	1    MKVWITGAGGMMGSHLAEMLLAAGHDVYATYCRPTIDPSDLQFNGAEVDITDWCSVYDSI   60
			  	61   ATFRPDAVFHLAAQSYPAVSWARPVETLTTNMVGTAIVFEALRRVRPHAKIIVAGSSAEY  120
			  	121  GFVDPSEVPINERRELRPLHPYGVSKAATDMLAYQYHKSYGMHTVVARIFNCTGPRKVGD  180
			  	181  ALSDFVRRCTWLEHHPEQSAIRVGNLKTKRTIVDVRDLNRALMLMLDKGEAGADYNVGGS  240
			  	241  IAYEMGDVLKQVIAACKRDDIVPEVDPALLRPTDEKIIYGDCSKLAAITGWQQEICLTQT  300
			  	301  IADMFDYWRSKSESALMV

Known structures in the PDB
No Known structures
1 32 63 94 125 156 187 218 249 280 311 Range: 3 to 238  |  Coverage: 73% Epimerase Range: 4 to 306  |  Coverage: 94% 1 Range: 1 to 318  |  Coverage: 99% 1
Number of amino acids : 318
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
EpimerasePF013703-238
Mtb Structural Proteome models
Model Number1
Model nameRv0112
Template1N7H    APDBCREDO
Template coverage32_349
Template Identity(%)28.1
Model coverage(%)95.0
Normalized DOPE score-0.557

Structure Models from Chopin
Model Number1
Profilec.2.1.2 - 3.40.50.720
Click for model details
zscore12.56
Residue begin1
Residue end318
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0112Gene nameConfidence Score
Rv0115hddA0.992
Rv0115hddA0.992
Rv3264cmanB0.971
Rv3264cmanB0.971
Rv1512epiA0.966
Rv0113gmhA0.915
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
Guanosine diphosphate-4-keto-6-deoxy-d-mannosePubChem0.924587.326
GDP-mannosePubChem0.922605.341