Rv0115

Tuberculist information
Gene namehddA
Protein functionPossible D-alpha-D-heptose-7-phosphate kinase HddA
Functional category(tuberculist)cell wall and cell processes
Gene location(kb)138.513
Molecular mass(da)40826.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 386
	  		  	1    MAILRGRAPLRLGLGGGGTDVEPYSSQFGGRILSVTIDKYAYAFAERGTGDEIAFRSPDR   60
			  	61   DRAGQASIDDLASLEEDFPLHVAVYRRVIAEFNGGTPFPLQLATQVDAPPGSGLGSSSAL  120
			  	121  VVAMLLTTCALIGSSPGPYELARLAWEIERVDLGMAGGWQDHYAAAFGGFNFMESRPNGE  180
			  	181  VVVNPLRIRREVIAELEASLLLYFGGVSRLSSEVIADQQRNVVERDADALAATHSICAEA  240
			  	241  LEMKDLLVVGDIPGFADSLLRGWQAKKRTSTRISNPAIEHAYQVAQSSGMVAGKVSGAGG  300
			  	301  GGFLMMIVDPRRRIEVARSLERECGGSVAPCLFTKGGAVTWHIPESTAPVRRGVADAVAS  360
			  	361  ALGNAGILLCAGCVLATSHSTWRVPV

Known structures in the PDB
No Known structures
1 39 77 115 153 191 229 267 305 343 381 Range: 101 to 169  |  Coverage: 17% GHMP_kinases_N Range: 236 to 326  |  Coverage: 23% GHMP_kinases_C Range: 2 to 363  |  Coverage: 93% 1 Range: 1 to 386  |  Coverage: 99% 1 Range: 236 to 326  |  Coverage: 23% 2 Range: 193 to 334  |  Coverage: 36% 3 Range: 101 to 169  |  Coverage: 17% 4 Range: 160 to 348  |  Coverage: 48% 5
Number of amino acids : 386
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
GHMP_kinases_NPF00288101-169
GHMP_kinases_CPF08544236-326
Mtb Structural Proteome models
Model Number1
Model nameRv0115
Template1KVK    APDBCREDO
Template coverage4_394
Template Identity(%)19.1
Model coverage(%)93.5
Normalized DOPE score0.418

Structure Models from Chopin
Model Number1
Profiled.14.1.5, d.58.26.7 - 3.30.230.10, 3.30.70.890
Click for model details
zscore26.38
Residue begin1
Residue end386
Model Number2
Profiled.58.26.7
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zscore17.44
Residue begin236
Residue end326
Model Number3
Profiled.58.26.4
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zscore15.16
Residue begin193
Residue end334
Model Number4
Profiled.14.1.5
Click for model details
zscore11.8
Residue begin101
Residue end169
Model Number5
Profile3.30.70.890
Click for model details
zscore8.92
Residue begin160
Residue end348
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0115Gene nameConfidence Score
Rv0112gca0.992
Rv0114gmhB0.986
Rv0113gmhA0.983
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions