SInCRe - Rv0113

Tuberculist information

Gene name	gmhA
Protein function	Probable sedoheptulose-7-phosphate isomerase GmhA (phosphoheptose isomerase)
Functional category(tuberculist)	cell wall and cell processes
Gene location(kb)	137.319
Molecular mass(da)	20890.6
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 196

	  		  	1    VCTARTAEEIFVETIAVKTRILNDRVLLEAARAIGDRLIAGYRAGARVFMCGNGGSAADA   60
			  	61   QHFAAELTGHLIFDRPPLGAEALHANSSHLTAVANDYDYDTVFARALEGSARPGDTLFAI  120
			  	121  STSGNSMSVLRAAKTARELGVTVVAMTGESGGQLAEFADFLINVPSRDTGRIQESHIVFI  180
			  	181  HAISEHVEHALFAPRQ

Known structures in the PDB

No Known structures

Number of amino acids : 196

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
SIS_2	PF13580	11-148

Mtb Structural Proteome models

Model Number	1
Model name	Rv0113
Template	1X92 APDB CREDO
Template coverage	5_195
Template Identity(%)	38.9
Model coverage(%)	96.4
Normalized DOPE score	-1.314

Structure Models from Chopin

Model Number	1
Profile	c.80.1.3 - 3.40.50.10490 Click for model details
zscore	30.91
Residue begin	1
Residue end	196

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv0113	Gene name	Confidence Score
Rv0114	gmhB	0.999
Rv0115	hddA	0.983
Rv0115	hddA	0.983
Rv0112	gca	0.915

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
D-glycero-D-manno-heptose 7-phosphatePubChem	0.876	290.162
L-glycero-D-manno-heptosePubChem	0.768	210.182
CHEBI:60203PubChem	0.76	288.146
sedoheptulose-7-phosphatePubChem	0.753	290.162
heptosePubChem	0.75	210.182
SeMetPubChem	0.73	196.106
selenomethioninePubChem	0.73	196.106