Rv0114

Tuberculist information
Gene namegmhB
Protein functionPossible D-alpha,beta-D-heptose-1,7-biphosphate phosphatase GmhB (D-glycero-D-manno-heptose 7-phosphate kinase)
Functional category(tuberculist)cell wall and cell processes
Gene location(kb)137.941
Molecular mass(da)20511.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 190
	  		  	1    MVAERAGHQWCLFLDRDGVINRQVVGDYVRNWRQFEWLPGAARALKKLRAWAPYIVVVTN   60
			  	61   QQGVGAGLMSAVDVMVIHRHLQMQLASDGVLIDGFQVCPHHRSQRCGCRKPRPGLVLDWL  120
			  	121  GRHPDSEPLLSIVVGDSLSDLELAHNVAAAAGACASVQIGGASSGGVADASFDSLWEFAV  180
			  	181  AVGHARGERG

Known structures in the PDB
No Known structures
1 20 39 58 77 96 115 134 153 172 191 Range: 11 to 148  |  Coverage: 72% PNK3P Range: 6 to 164  |  Coverage: 83% 1 Range: 1 to 190  |  Coverage: 99% 1
Number of amino acids : 190
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
PNK3PPF0864511-148
Mtb Structural Proteome models
Model Number1
Model nameRv0114
Template1YJ5    APDBCREDO
Template coverage161_333
Template Identity(%)21.4
Model coverage(%)83.2
Normalized DOPE score0.221

Structure Models from Chopin
Model Number1
Profilec.108.1.19 - 3.40.50.1000
Click for model details
zscore43.07
Residue begin1
Residue end190
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0114Gene nameConfidence Score
Rv0113gmhA0.999
Rv0115hddA0.986
Rv0115hddA0.986
Rv1601hisB0.968
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
phosphatePubChem0.80496.9872
D-glycero-D-manno-heptose-1,7-bisphosphatePubChem0.801370.142
SeMetPubChem0.775196.106
selenomethioninePubChem0.775196.106
magnesiumPubChem0.77424.305
zincPubChem0.76165.409
hydron diphosphatePubChem0.759391.981