Rv0322

Tuberculist information
Gene nameudgA
Protein functionProbable UDP-glucose 6-dehydrogenase UdgA (UDP-GLC dehydrogenase) (UDP-GLCDH) (UDPGDH)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)389.26
Molecular mass(da)47330.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 443
	  		  	1    VRCSVFGTGYLGATHAVGMAQLGHEVVGVDIDPGKVAKLAGGDIPFYEPGLRKLLTDNLA   60
			  	61   AGRLRFTTDYDMAADFADVHFLGVGTPQKIGEYGADLRHVHAVIDALVPRLVRASILVGK  120
			  	121  STVPVGTAAELGHRAGALAPRGVDVEIAWNPEFLREGFAVHDTLNPDRIVLGVQDDSTRA  180
			  	181  EVAVRELYAPLLAAGVPFLVTDLQTAELVKVSANAFLATKISFINAISEVCEAAGADVSQ  240
			  	241  LADALGYDPRIGRQCLNAGLGFGGGCLPKDIRAFMARAGELGADQALTFLREVDSINMRR  300
			  	301  RTKMVELATTACGGSLLGANIAVLGAAFKPESDDVRDSPALNVAGQLQLNGATVHVYDPK  360
			  	361  ALDNAHRLFPTLNYAVSVAEACERADAVLVLTEWREFIDLEPADLANRVRARVIVDGRNC  420
			  	421  LDVTRWRRAGWRVFRLGVPRLGH

Known structures in the PDB
No Known structures
1 45 89 133 177 221 265 309 353 397 441 Range: 1 to 187  |  Coverage: 41% UDPG_MGDP_dh_N Range: 203 to 300  |  Coverage: 21% UDPG_MGDP_dh Range: 322 to 423  |  Coverage: 22% UDPG_MGDP_dh_C Range: 1 to 434  |  Coverage: 97% 1 Range: 1 to 187  |  Coverage: 41% 1
Number of amino acids : 443
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
UDPG_MGDP_dh_NPF037211-187
UDPG_MGDP_dhPF00984203-300
UDPG_MGDP_dh_CPF03720322-423
Mtb Structural Proteome models
Model Number1
Model nameRv0322
Template1MV8    APDBCREDO
Template coverage1_436
Template Identity(%)29.3
Model coverage(%)97.7
Normalized DOPE score0.409

Structure Models from Chopin
Model Number1
Profilec.2.1.4
Click for model details
zscore9.13
Residue begin1
Residue end187
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0322Gene nameConfidence Score
Rv3634cgalE10.991
Rv0993galU0.99
Rv0536galE30.954
Rv0334rmlA0.941
Rv1511gmdA0.923
Rv3464rmlB0.905
Rv0619galTb0.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
UDPGAPubChem0.992580.285
UDP-glucosePubChem0.991566.302
NAD+PubChem0.984663.425
UDP-xylosePubChem0.983536.276
UDP-GlcPubChem0.962566.302
UDP-galactosePubChem0.954566.302
UDxPubChem0.951536.276
UDP-apiosePubChem0.938536.276
uridine diphosphate galactosePubChem0.932566.302
UDP-galacturonatePubChem0.932580.285
reduced nicotinamide adenine dinucleotidePubChem0.931665.441
glucose-1-phosphatePubChem0.914260.136
pyrophosphatePubChem0.909177.975
UDP-d-galacturonatePubChem0.9580.285
hydroxyl radicalsPubChem0.917.0073
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
carbon dioxidePubChem0.944.0095
uridine triphosphatePubChem0.9484.141
deuteriumPubChem0.92.01588
H(+)PubChem0.92.01588
[(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl] [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-PubChem0.9534.26
protiumPubChem0.92.01576
glucuronic acidPubChem0.758194.139
hyaluronic acidPubChem0.731846.781
glycerolPubChem0.71892.0938