Rv0993

Tuberculist information
Gene namegalU
Protein functionUTP--glucose-1-phosphate uridylyltransferase GalU (UDP-glucose pyrophosphorylase) (UDPGP) (alpha-D-glucosyl-1-phosphate uridylyltransferase) (uridine diphosphoglucose pyrophosphorylase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1109.27
Molecular mass(da)32378.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 306
	  		  	1    MSRPEVLTPFTAIVPAAGLGTRFLPATKTVPKELLPVVDTPGIELVAAEAAAAGAERLVI   60
			  	61   VTSEGKDGVVAHFVEDLVLEGTLEARGKIAMLAKVRRAPALIKVESVVQAEPLGLGHAIG  120
			  	121  CVEPTLSPDEDAVAVLLPDDLVLPTGVLETMSKVRASRGGTVLCAIEVAREEISAYGVFD  180
			  	181  VEPVPDGDYTDDPNVLKVRGMVEKPKAETAPSRYAAAGRYVLDRAIFDALRRIDQGAGGE  240
			  	241  VQLTDAIALLIAEGHPVHVVVHQGSRHDLGNPGGYLKAAVDFALDRDDYGPDLRRWLVAR  300
			  	301  LGLTEQ

Known structures in the PDB
No Known structures
1 31 61 91 121 151 181 211 241 271 301 Range: 11 to 284  |  Coverage: 89% NTP_transferase Range: 9 to 306  |  Coverage: 97% 1 Range: 6 to 306  |  Coverage: 98% 1
Number of amino acids : 306
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
NTP_transferasePF0048311-284
Mtb Structural Proteome models
Model Number1
Model nameRv0993
Template1FXO    APDBCREDO
Template coverage2_255
Template Identity(%)26.0
Model coverage(%)97.1
Normalized DOPE score0.713

Structure Models from Chopin
Model Number1
Profilec.68.1.6 - 3.90.550.10
Click for model details
zscore23.58
Residue begin6
Residue end306
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0993Gene nameConfidence Score
Rv3257cpmmA0.995
Rv3257cpmmA0.995
Rv3257cpmmA0.995
Rv3257cpmmA0.995
Rv3441cmrsA0.994
Rv3441cmrsA0.994
Rv3441cmrsA0.994
Rv3441cmrsA0.994
Rv0322udgA0.99
Rv0322udgA0.99
Rv0322udgA0.99
Rv3634cgalE10.989
Rv1656argF0.98
Rv1656argF0.98
Rv0620galK0.977
Rv0620galK0.977
Rv3490otsA0.977
Rv0620galK0.977
Rv0682rpsL0.976
Rv3628ppa0.974
Rv2427cproA0.969
Rv0334rmlA0.963
Rv3308pmmB0.952
Rv3308pmmB0.952
Rv3308pmmB0.952
Rv3308pmmB0.952
Rv1213glgC0.948
Rv2528cmrr0.948
Rv1213glgC0.948
Rv2528cmrr0.948
Rv3068cpgmA0.945
Rv3068cpgmA0.945
Rv3068cpgmA0.945
Rv3068cpgmA0.945
Rv3266crmlD0.936
Rv0536galE30.935
Rv0806ccpsY0.933
Rv3436cglmS0.927
Rv3436cglmS0.927
Rv0619galTb0.912
Rv1328glgP0.907
Rv1328glgP0.907
Rv0618galTa0.906
Rv0501galE20.906
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
UDP-glucosePubChem0.996566.302
glucose-1-phosphatePubChem0.981260.136
UDP-galactosePubChem0.967566.302
pyrophosphatePubChem0.962177.975
uridine triphosphatePubChem0.957484.141
UDP-GlcPubChem0.956566.302
phosphatePubChem0.92196.9872
galactose-1-phosphatePubChem0.912336.316
glucose-6-phosphatePubChem0.909260.136
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
protiumPubChem0.92.01576
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
H(+)PubChem0.92.01588
UDPGAPubChem0.9580.285
deuteriumPubChem0.92.01588
alpha-D-glucose 6-phosphatePubChem0.9260.136
NAD+PubChem0.9663.425
uridine diphosphate galactosePubChem0.9566.302
hydroxyl radicalsPubChem0.917.0073
magnesiumPubChem0.82124.305