Rv0682

Tuberculist information
Gene namerpsL
Protein function30S ribosomal protein S12 RpsL
Functional category(tuberculist)information pathways
Gene location(kb)781.56
Molecular mass(da)13849.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 124
	  		  	1    MPTIQQLVRKGRRDKISKVKTAALKGSPQRRGVCTRVYTTTPKKPNSALRKVARVKLTSQ   60
			  	61   VEVTAYIPGEGHNLQEHSMVLVRGGRVKDLPGVRYKIIRGSLDTQGVKNRKQARSRYGAK  120
			  	121  KEKG

Known structures in the PDB
No Known structures
1 13 25 37 49 61 73 85 97 109 121 Range: 2 to 123  |  Coverage: 97% Ribosomal_S12 Range: 2 to 123  |  Coverage: 97% 1
Number of amino acids : 124
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Ribosomal_S12PF001642-123
Mtb Structural Proteome models
Model Number1
Model nameRv0682
Template1FJG    LPDBCREDO
Template coverage5_126
Template Identity(%)73.8
Model coverage(%)97.6
Normalized DOPE score-0.279

Structure Models from Chopin
CHOPIN models not available for this query
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0682Gene nameConfidence Score
Rv0667rpoB0.999
Rv0667rpoB0.999
Rv0667rpoB0.999
Rv0667rpoB0.999
Rv0667rpoB0.999
Rv0683rpsG0.999
Rv3458crpsD0.999
Rv0667rpoB0.999
Rv3458crpsD0.999
Rv0710rpsQ0.998
Rv0684fusA10.998
Rv3459crpsK0.998
Rv0705rpsS0.998
Rv0700rpsJ0.998
Rv0684fusA10.998
Rv3460crpsM0.998
Rv0640rplK0.998
Rv0684fusA10.998
Rv0640rplK0.998
Rv0707rpsC0.998
Rv0721rpsE0.998
Rv0684fusA10.998
Rv0707rpsC0.998
Rv0721rpsE0.998
Rv0684fusA10.998
Rv0718rpsH0.998
Rv0641rplA0.997
Rv0685tuf0.997
Rv3442crpsI0.997
Rv0685tuf0.997
Rv0685tuf0.997
Rv0651rplJ0.996
Rv0708rplP0.996
Rv2890crpsB0.995
Rv0717rpsN10.995
Rv0719rplF0.993
Rv3457crpoA0.993
Rv2056crpsN20.993
Rv3457crpoA0.993
Rv3457crpoA0.993
Rv0714rplN0.992
Rv0706rplV0.991
Rv0720rplR0.991
Rv0704rplB0.991
Rv0723rplO0.991
Rv0704rplB0.991
Rv2785crpsO0.991
Rv0701rplC0.99
Rv0715rplX0.99
Rv0702rplD0.99
Rv0716rplE0.99
Rv0716rplE0.99
Rv0652rplL0.99
Rv3443crplM0.99
Rv0668rpoC0.989
Rv3456crplQ0.989
Rv0668rpoC0.989
Rv0668rpoC0.989
Rv0668rpoC0.989
Rv0703rplW0.989
Rv0053rpsF0.989
Rv0668rpoC0.989
Rv0732secY0.988
Rv2889ctsf0.986
Rv2889ctsf0.986
Rv3462cinfA0.984
Rv0639nusG0.981
Rv2909crpsP0.981
Rv0639nusG0.981
Rv1641infC0.98
Rv1641infC0.98
Rv0722rpmD0.979
Rv2528cmrr0.976
Rv0620galK0.976
Rv0993galU0.976
Rv0620galK0.976
Rv0620galK0.976
Rv2528cmrr0.976
Rv2882cfrr0.973
Rv1908ckatG0.971
Rv2412rpsT0.971
Rv0006gyrA0.97
Rv0006gyrA0.97
Rv1656argF0.969
Rv1656argF0.969
Rv2428ahpC0.969
Rv2756chsdM0.967
Rv2756chsdM0.967
Rv0005gyrB0.965
Rv0005gyrB0.965
Rv0005gyrB0.965
Rv0005gyrB0.965
Rv0055rpsR10.964
Rv1630rpsA0.964
Rv0120cfusA20.963
Rv0120cfusA20.963
Rv1010ksgA0.963
Rv0120cfusA20.963
Rv0120cfusA20.963
Rv2906ctrmD0.963
Rv0120cfusA20.963
Rv0733adk0.962
Rv2427cproA0.957
Rv2442crplU0.956
Rv2904crplS0.953
Rv3919cgid0.952
Rv2043cpncA0.949
Rv0709rpmC0.949
Rv0056rplI0.948
Rv0056rplI0.948
Rv0634BrpmG20.947
Rv3100csmpB0.939
Rv1023eno0.937
Rv1023eno0.937
Rv2534cefp0.934
Rv2534cefp0.934
Rv2534cefp0.934
Rv1643rplT0.931
Rv2907crimM0.928
Rv2907crimM0.928
Rv2462ctig0.918
Rv2462ctig0.918
Rv2462ctig0.918
Rv1694tlyA0.913
Rv1694tlyA0.913
Rv2697cdut0.912
Rv2441crpmA0.909
Rv1298rpmE0.909
Rv1015crplY0.908
Rv1015crplY0.908
Rv3461crpmJ0.907
Rv1017cprsA0.901
Rv2783cgpsI0.901
Rv2783cgpsI0.901
Rv2783cgpsI0.901
Rv2057crpmG10.901
Rv2992cgltS0.901
Rv2783cgpsI0.901
Rv2783cgpsI0.901
Rv1017cprsA0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
DrugBank IDDrug Name
DB00452DrugBankFramycetin
DB00479DrugBankAmikacin
DB00560DrugBankTigecycline
DB00684DrugBankTobramycin
DB00798DrugBankGentamicin
DB00919DrugBankSpectinomycin
DB00955DrugBankNetilmicin
DB00994DrugBankNeomycin
DB01082DrugBankStreptomycin
DB01172DrugBankKanamycin
DB06696DrugBankArbekacin
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
streptomycinPubChem0.983581.574
kirromycinPubChem0.916796.943
spectinomycinPubChem0.899332.35
kanamycinPubChem0.882484.499
rifampicinPubChem0.86822.94
magnesiumPubChem0.84524.305
[3,4-dihydroxy-5-(2-methylamino-6-oxo-3H-purin-9-yl)oxolan-2-yl]methoxyphosphonic AcidPubChem0.789377.247
guanosine diphosphatePubChem0.789443.201
ethambutolPubChem0.753204.31
isoniazidPubChem0.747137.139
pyrazinamidePubChem0.732123.113
MABAPubChem0.711137.136
poly(2'-O-methyladenylic acid)PubChem0.71361.248
pseudouridine 5'-phosphatePubChem0.71324.181
methyl 4-[3-[3,4-dihydroxy-5-(phosphonooxymethyl)oxolan-2-yl]-4,6-dimethyl-9-oxoimidazo[1,2-a]purin-PubChem0.71588.462
poly CPubChem0.71323.197
ara-TMPPubChem0.71338.208
MYC-8003PubChem0.71796.943
potassium hydridePubChem0.7140.1062
beta-lysinePubChem0.71146.188
5-methylcytidylic acidPubChem0.71337.223
2-mercaptoethanolPubChem0.7178.1334
[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl phosphatePubChem0.71338.208
[3,4-dihydroxy-5-(6-imino-1-methyl-purin-9-yl)oxolan-2-yl]methoxyphosphonic AcidPubChem0.71361.248
pactamycinPubChem0.71558.623
guanylatePubChem0.71363.221
adenosine 3',5'-diphosphatePubChem0.71427.201
C04639PubChem0.71326.197
3'-phosphoadenosine 5'-phosphatePubChem0.71427.201
CSIPubChem0.71172.185
kasugamycinPubChem0.71379.363
L-beta-lysinePubChem0.71146.188
phenylalaninalPubChem0.71149.19
adenosine monophosphatePubChem0.71347.221
7mgPubChem0.71379.263
pseudouridylic acidPubChem0.71324.181
CHEBI:603702PubChem0.71558.623
UD29PubChem0.71340.247
guanylyl-(alpha,beta)-methylene-diphosphonatePubChem0.71521.208
2,3-diaminopropionic acidPubChem0.71104.108
2'-O-methylguanosine 5'-monophosphatePubChem0.71377.247
polyuridylic acidPubChem0.71324.181
[(2R,3S,4R,5R)-5-[2-(dimethylamino)-6-oxo-3H-purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen PubChem0.71391.274
L-2,3-diaminopropionic acidPubChem0.71104.108
[5-(2-dimethylamino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxyphosphonic AcidPubChem0.71391.274
poly(2'-O-methylcytidylic acid)PubChem0.71337.223
C07026PubChem0.71346.236
DB08185PubChem0.71463.446
zincPubChem0.7165.409
potassiumPubChem0.7139.0983
3'-amino-3'-deoxy AMPPubChem0.71346.236
fusidic acidPubChem0.71516.709
methylthioadenosinePubChem0.708297.333
5'-deoxy-5'-methylthioadenosinePubChem0.7297.333