Rv0668

Tuberculist information
Gene namerpoC
Protein functionDNA-directed RNA polymerase (beta' chain) RpoC (transcriptase beta' chain) (RNA polymerase beta' subunit).
Functional category(tuberculist)information pathways
Gene location(kb)763.37
Molecular mass(da)146737
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 1316
	  		  	1    VLDVNFFDELRIGLATAEDIRQWSYGEVKKPETINYRTLKPEKDGLFCEKIFGPTRDWEC   60
			  	61   YCGKYKRVRFKGIICERCGVEVTRAKVRRERMGHIELAAPVTHIWYFKGVPSRLGYLLDL  120
			  	121  APKDLEKIIYFAAYVITSVDEEMRHNELSTLEAEMAVERKAVEDQRDGELEARAQKLEAD  180
			  	181  LAELEAEGAKADARRKVRDGGEREMRQIRDRAQRELDRLEDIWSTFTKLAPKQLIVDENL  240
			  	241  YRELVDRYGEYFTGAMGAESIQKLIENFDIDAEAESLRDVIRNGKGQKKLRALKRLKVVA  300
			  	301  AFQQSGNSPMGMVLDAVPVIPPELRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLIDL  360
			  	361  GAPEIIVNNEKRMLQESVDALFDNGRRGRPVTGPGNRPLKSLSDLLKGKQGRFRQNLLGK  420
			  	421  RVDYSGRSVIVVGPQLKLHQCGLPKLMALELFKPFVMKRLVDLNHAQNIKSAKRMVERQR  480
			  	481  PQVWDVLEEVIAEHPVLLNRAPTLHRLGIQAFEPMLVEGKAIQLHPLVCEAFNADFDGDQ  540
			  	541  MAVHLPLSAEAQAEARILMLSSNNILSPASGRPLAMPRLDMVTGLYYLTTEVPGDTGEYQ  600
			  	601  PASGDHPETGVYSSPAEAIMAADRGVLSVRAKIKVRLTQLRPPVEIEAELFGHSGWQPGD  660
			  	661  AWMAETTLGRVMFNELLPLGYPFVNKQMHKKVQAAIINDLAERYPMIVVAQTVDKLKDAG  720
			  	721  FYWATRSGVTVSMADVLVPPRKKEILDHYEERADKVEKQFQRGALNHDERNEALVEIWKE  780
			  	781  ATDEVGQALREHYPDDNPIITIVDSGATGNFTQTRTLAGMKGLVTNPKGEFIPRPVKSSF  840
			  	841  REGLTVLEYFINTHGARKGLADTALRTADSGYLTRRLVDVSQDVIVREHDCQTERGIVVE  900
			  	901  LAERAPDGTLIRDPYIETSAYARTLGTDAVDEAGNVIVERGQDLGDPEIDALLAAGITQV  960
			  	961  KVRSVLTCATSTGVCATCYGRSMATGKLVDIGEAVGIVAAQSIGEPGTQLTMRTFHQGGV 1020
			  	1021 GEDITGGLPRVQELFEARVPRGKAPIADVTGRVRLEDGERFYKITIVPDDGGEEVVYDKI 1080
			  	1081 SKRQRLRVFKHEDGSERVLSDGDHVEVGQQLMEGSADPHEVLRVQGPREVQIHLVREVQE 1140
			  	1141 VYRAQGVSIHDKHIEVIVRQMLRRVTIIDSGSTEFLPGSLIDRAEFEAENRRVVAEGGEP 1200
			  	1201 AAGRPVLMGITKASLATDSWLSAASFQETTRVLTDAAINCRSDKLNGLKENVIIGKLIPA 1260
			  	1261 GTGINRYRNIAVQPTEEARAAAYTIPSYEDQYYSPDFGAATGAAVPLDDYGYSDYR

Known structures in the PDB
No Known structures
1 132 263 394 525 656 787 918 1049 1180 1311 Range: 4 to 417  |  Coverage: 31% RNA_pol_Rpb1_1 Range: 419 to 561  |  Coverage: 10% RNA_pol_Rpb1_2 Range: 564 to 736  |  Coverage: 13% RNA_pol_Rpb1_3 Range: 748 to 843  |  Coverage: 7% RNA_pol_Rpb1_4 Range: 843 to 1223  |  Coverage: 28% RNA_pol_Rpb1_5 Range: 4 to 287  |  Coverage: 21% 1 Range: 3 to 1292  |  Coverage: 97% 1
Number of amino acids : 1316
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
RNA_pol_Rpb1_1PF049974-417
RNA_pol_Rpb1_2PF00623419-561
RNA_pol_Rpb1_3PF04983564-736
RNA_pol_Rpb1_4PF05000748-843
RNA_pol_Rpb1_5PF04998843-1223
Mtb Structural Proteome models
Model Number1
Model nameRv0668
Template2A6H    DPDBCREDO
Template coverage2_1504
Template Identity(%)47.9
Model coverage(%)97.7
Normalized DOPE score0.754

Structure Models from Chopin
Model Number1
Profilee.29.1.2
Click for model details
zscore136.62
Residue begin3
Residue end1292
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0668Gene nameConfidence Score
Rv3457crpoA0.999
Rv0667rpoB0.999
Rv0667rpoB0.999
Rv0667rpoB0.999
Rv0667rpoB0.999
Rv0667rpoB0.999
Rv3457crpoA0.999
Rv0667rpoB0.999
Rv3457crpoA0.999
Rv0652rplL0.997
Rv0707rpsC0.996
Rv0707rpsC0.996
Rv0639nusG0.995
Rv0721rpsE0.995
Rv0639nusG0.995
Rv0721rpsE0.995
Rv0701rplC0.994
Rv3458crpsD0.993
Rv3458crpsD0.993
Rv0704rplB0.992
Rv0732secY0.992
Rv0704rplB0.992
Rv0705rpsS0.992
Rv0641rplA0.991
Rv0714rplN0.991
Rv2783cgpsI0.99
Rv0708rplP0.99
Rv2783cgpsI0.99
Rv2783cgpsI0.99
Rv0700rpsJ0.99
Rv2783cgpsI0.99
Rv0651rplJ0.99
Rv2783cgpsI0.99
Rv0682rpsL0.989
Rv1699pyrG0.989
Rv1699pyrG0.989
Rv0683rpsG0.988
Rv0702rplD0.988
Rv3460crpsM0.987
Rv0710rpsQ0.986
Rv0703rplW0.985
Rv0719rplF0.985
Rv0716rplE0.984
Rv0706rplV0.984
Rv0716rplE0.984
Rv0723rplO0.983
Rv0640rplK0.983
Rv0640rplK0.983
Rv3459crpsK0.982
Rv0684fusA10.981
Rv0684fusA10.981
Rv0684fusA10.981
Rv0684fusA10.981
Rv0684fusA10.981
Rv0720rplR0.98
Rv3456crplQ0.978
Rv0718rpsH0.977
Rv2839cinfB0.974
Rv2839cinfB0.974
Rv2839cinfB0.974
Rv2839cinfB0.974
Rv0685tuf0.969
Rv1617pykA0.969
Rv0685tuf0.969
Rv2703sigA0.969
Rv1617pykA0.969
Rv0685tuf0.969
Rv2703sigA0.969
Rv2703sigA0.969
Rv2703sigA0.969
Rv2445cndkA0.966
Rv2710sigB0.964
Rv2710sigB0.964
Rv0717rpsN10.964
Rv2710sigB0.964
Rv2710sigB0.964
Rv2583crelA0.959
Rv2583crelA0.959
Rv2583crelA0.959
Rv2583crelA0.959
Rv3442crpsI0.95
Rv3443crplM0.948
Rv0715rplX0.946
Rv1341Rv13410.945
Rv2343cdnaG0.943
Rv2343cdnaG0.943
Rv2343cdnaG0.943
Rv2343cdnaG0.943
Rv2343cdnaG0.943
Rv0120cfusA20.942
Rv3646ctopA0.942
Rv0120cfusA20.942
Rv0120cfusA20.942
Rv0120cfusA20.942
Rv0120cfusA20.942
Rv3646ctopA0.942
Rv3646ctopA0.942
Rv2462ctig0.94
Rv2462ctig0.94
Rv2462ctig0.94
Rv1023eno0.937
Rv1023eno0.937
Rv0734mapA0.931
Rv0733adk0.927
Rv2572caspS0.918
Rv2572caspS0.918
Rv2572caspS0.918
Rv0709rpmC0.914
Rv1080cgreA0.913
Rv1080cgreA0.913
Rv2889ctsf0.911
Rv1292argS0.911
Rv1292argS0.911
Rv1292argS0.911
Rv2889ctsf0.911
Rv0634BrpmG20.91
Rv0005gyrB0.909
Rv0005gyrB0.909
Rv0005gyrB0.909
Rv2056crpsN20.909
Rv0005gyrB0.909
Rv2580chisS0.907
Rv2580chisS0.907
Rv2448cvalS0.905
Rv2448cvalS0.905
Rv2448cvalS0.905
Rv1021Rv10210.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
rifampicinPubChem0.916822.94
adenosine triphosphatePubChem0.9507.181
guanosine triphosphatePubChem0.9523.18
cytidine triphosphatePubChem0.9483.156
ara-CTPPubChem0.9483.156
uridine triphosphatePubChem0.9484.141
guanosine tetraphosphatePubChem0.87603.16
rifabutinPubChem0.841847.005
rifapentinePubChem0.8877.031
magnesiumPubChem0.78724.305
zincPubChem0.78765.409