Rv2710

Tuberculist information
Gene namesigB
Protein functionRNA polymerase sigma factor SigB
Functional category(tuberculist)information pathways
Gene location(kb)3022.46
Molecular mass(da)36343.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 323
	  		  	1    MADAPTRATTSRVDSDLDAQSPAADLVRVYLNGIGKTALLNAAGEVELAKRIEAGLYAEH   60
			  	61   LLETRKRLGENRKRDLAAVVRDGEAARRHLLEANLRLVVSLAKRYTGRGMPLLDLIQEGN  120
			  	121  LGLIRAMEKFDYTKGFKFSTYATWWIRQAITRGMADQSRTIRLPVHLVEQVNKLARIKRE  180
			  	181  MHQHLGREATDEELAAESGIPIDKINDLLEHSRDPVSLDMPVGSEEEAPLGDFIEDAEAM  240
			  	241  SAENAVIAELLHTDIRSVLATLDEREHQVIRLRFGLDDGQPRTLDQIGKLFGLSRERVRQ  300
			  	301  IERDVMSKLRHGERADRLRSYAS

Known structures in the PDB
No Known structures
1 33 65 97 129 161 193 225 257 289 321 Range: 24 to 60  |  Coverage: 11% Sigma70_r1_2 Range: 90 to 160  |  Coverage: 21% Sigma70_r2 Range: 169 to 246  |  Coverage: 23% Sigma70_r3 Range: 258 to 311  |  Coverage: 16% Sigma70_r4 Range: 22 to 322  |  Coverage: 92% 1 Range: 1 to 323  |  Coverage: 99% 1 Range: 90 to 156  |  Coverage: 20% 2 Range: 160 to 238  |  Coverage: 24% 3 Range: 258 to 311  |  Coverage: 16% 4 Range: 240 to 323  |  Coverage: 25% 5
Number of amino acids : 323
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Sigma70_r1_2PF0014024-60
Sigma70_r2PF0454290-160
Sigma70_r3PF04539169-246
Sigma70_r4PF04545258-311
Mtb Structural Proteome models
Model Number1
Model nameRv2710
Template2A6H    FPDBCREDO
Template coverage76_422
Template Identity(%)48.2
Model coverage(%)92.9
Normalized DOPE score0.674

Structure Models from Chopin
Model Number1
Profilea.177.1.1, a.4.13.1, a.4.13.2 - 1.10.10.10
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zscore50.25
Residue begin1
Residue end323
Model Number2
Profilea.177.1.1 - 1.10.601.10
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zscore30.31
Residue begin90
Residue end156
Model Number3
Profilea.4.13.1
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zscore9.88
Residue begin160
Residue end238
Model Number4
Profilea.4.13.2 - 1.10.10.10
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zscore8.97
Residue begin258
Residue end311
Model Number5
Profilea.4.13.2 - 1.10.10.10
Click for model details
zscore8.67
Residue begin240
Residue end323
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2710Gene nameConfidence Score
Rv0667rpoB0.996
Rv0667rpoB0.996
Rv0667rpoB0.996
Rv0667rpoB0.996
Rv0667rpoB0.996
Rv0667rpoB0.996
Rv2343cdnaG0.965
Rv2343cdnaG0.965
Rv2343cdnaG0.965
Rv2343cdnaG0.965
Rv2343cdnaG0.965
Rv0668rpoC0.964
Rv0668rpoC0.964
Rv0668rpoC0.964
Rv0668rpoC0.964
Rv0668rpoC0.964
Rv3457crpoA0.955
Rv3457crpoA0.955
Rv3457crpoA0.955
Rv3223csigH0.947
Rv3223csigH0.947
Rv2711ideR0.934
Rv2711ideR0.934
Rv2711ideR0.934
Rv0350dnaK0.928
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions