Rv2572c

Tuberculist information
Gene nameaspS
Protein functionProbable aspartyl-tRNA synthetase AspS (aspartate--tRNA ligase) (ASPRS) (aspartic acid translase)
Functional category(tuberculist)information pathways
Gene location(kb)2896.01
Molecular mass(da)65194.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 596
	  		  	1    VFVLRSHAAGLLREGDAGQQVTLAGWVARRRDHGGVIFIDLRDASGIAQVVFRDPQDTEV   60
			  	61   LAQAHRLRAEFCVSVAGVVEIRPEGNANPEIATGEIEVNATSLTVLGECAPLPFQLDEPA  120
			  	121  GEELRLKYRYLDLRRDDPAAAIRLRSRVNAAARAVLARHDFVEIETPTITRSTPEGARDF  180
			  	181  LVPARLHPGSFYALPQSPQLFKQLLMVAGMERYYQIARCYRDEDFRADRQPEFTQLDMEM  240
			  	241  SFVDAEDIIAISEEVLTELWALIGYRIPTPIPRIGYAEAMRRFGTDKPDLRFGLELVECT  300
			  	301  DFFSDTTFRVFQAPYVGAVVMPGGASQPRRTLDGWQDWAKQRGHRGLAYVLVAEDGTLGG  360
			  	361  PVAKNLTEAERTGLADHVGAKPGDCIFFSAGPVKSSRALLGAARVEIANRLGLIDPDAWA  420
			  	421  FVWVVDPPLFEPADEATAAGEVAVGSGAWTAVHHAFTAPKPEWEDRIESDTGSVLADAYD  480
			  	481  IVCNGHEIGGGSVRIHRRDIQERVFAVMGLDKAEAEEKFGFLLEAFMFGAPPHGGIAFGW  540
			  	541  DRTTALLAGMDSIREVIAFPKTGGGVDPLTDAPAPITAQQRKESGIDAQPKRVQQA

Known structures in the PDB
No Known structures
1 60 119 178 237 296 355 414 473 532 591 Range: 19 to 104  |  Coverage: 14% tRNA_anti-codon Range: 119 to 562  |  Coverage: 74% tRNA-synt_2 Range: 307 to 398  |  Coverage: 15% GAD Range: 3 to 588  |  Coverage: 98% 1 Range: 3 to 591  |  Coverage: 98% 1 Range: 274 to 414  |  Coverage: 23% 2 Range: 21 to 106  |  Coverage: 14% 3 Range: 1 to 114  |  Coverage: 18% 4 Range: 7 to 591  |  Coverage: 97% 5
Number of amino acids : 596
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
tRNA_anti-codonPF0133619-104
tRNA-synt_2PF00152119-562
GADPF02938307-398
Mtb Structural Proteome models
Model Number1
Model nameRv2572c
Template1L0W    APDBCREDO
Template coverage1_577
Template Identity(%)51.8
Model coverage(%)98.0
Normalized DOPE score0.215

Structure Models from Chopin
Model Number1
Profileb.40.4.1, d.74.4.1 - 2.40.50.140, 3.30.1360.30, 3.30.930.10
Click for model details
zscore92.64
Residue begin3
Residue end591
Model Number2
Profile3.30.1360.30
Click for model details
zscore26.93
Residue begin274
Residue end414
Model Number3
Profileb.40.4.1
Click for model details
zscore21.66
Residue begin21
Residue end106
Model Number4
Profileb.40.4.1
Click for model details
zscore17.71
Residue begin1
Residue end114
Model Number5
Profile3.30.930.10
Click for model details
zscore13.03
Residue begin7
Residue end591
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2572cGene nameConfidence Score
Rv2580chisS0.977
Rv2580chisS0.977
Rv2555calaS0.971
Rv2555calaS0.971
Rv2555calaS0.971
Rv3009cgatB0.97
Rv3009cgatB0.97
Rv2614cthrS0.966
Rv2614cthrS0.966
Rv2614cthrS0.966
Rv2839cinfB0.96
Rv2839cinfB0.96
Rv2839cinfB0.96
Rv2839cinfB0.96
Rv1292argS0.957
Rv1292argS0.957
Rv1292argS0.957
Rv1689tyrS0.955
Rv1689tyrS0.955
Rv3336ctrpS0.948
Rv2448cvalS0.942
Rv2448cvalS0.942
Rv2448cvalS0.942
Rv0041leuS0.935
Rv0041leuS0.935
Rv0041leuS0.935
Rv0716rplE0.93
Rv0716rplE0.93
Rv2992cgltS0.929
Rv1007cmetS0.928
Rv2845cproS0.926
Rv2845cproS0.926
Rv2845cproS0.926
Rv1649pheS0.925
Rv1649pheS0.925
Rv3011cgatA0.924
Rv0668rpoC0.918
Rv0668rpoC0.918
Rv0668rpoC0.918
Rv0668rpoC0.918
Rv0668rpoC0.918
Rv0056rplI0.917
Rv0056rplI0.917
Rv0719rplF0.915
Rv0732secY0.908
Rv2441crpmA0.907
Rv2603cRv2603c0.907
Rv1641infC0.904
Rv1641infC0.904
Rv1299prfA0.903
Rv1299prfA0.903
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
adenosine monophosphatePubChem0.978347.221
aspartatePubChem0.952133.103
adenosine triphosphatePubChem0.917507.181
pyrophosphatePubChem0.912177.975
sulfatePubChem0.7996.0626
AmoPubChem0.79462.309
DB01895PubChem0.79462.309
hydron sulfatePubChem0.79196.157
[5-[2-amino-5-[[(2,3-dihydroxycyclopentyl)amino]methyl]-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-7-yl]-3,4-dPubChem0.787491.39
magnesiumPubChem0.76124.305
[5-(6-amino-2-methyl-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxyphosphonic AcidPubChem0.7361.248