Rv1641

Tuberculist information
Gene nameinfC
Protein functionProbable initiation factor if-3 InfC
Functional category(tuberculist)information pathways
Gene location(kb)1852.27
Molecular mass(da)22315.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 201
	  		  	1    ISTETRVNERIRVPEVRLIGPGGEQVGIVRIEDALRVAADADLDLVEVAPNARPPVCKIM   60
			  	61   DYGKYKYEAAQKARESRRNQQQTVVKEQKLRPKIDDHDYETKKGHVVRFLEAGSKVKVTI  120
			  	121  MFRGREQSRPELGYRLLQRLGADVADYGFIETSAKQDGRNMTMVLAPHRGAKTRARARHP  180
			  	181  GEPAGGPPPKPTAGDSKAAPN

Known structures in the PDB
No Known structures
1 21 41 61 81 101 121 141 161 181 201 Range: 2 to 77  |  Coverage: 37% IF3_N Range: 82 to 169  |  Coverage: 43% IF3_C Range: 7 to 78  |  Coverage: 35% 1 Range: 83 to 171  |  Coverage: 43% 2 Range: 82 to 172  |  Coverage: 44% 1 Range: 3 to 78  |  Coverage: 37% 2
Number of amino acids : 201
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
IF3_NPF051982-77
IF3_CPF0070782-169
Mtb Structural Proteome models
Model Number1
Model nameRv1641
Template1TIF    APDBCREDO
Template coverage7_78
Template Identity(%)55.6
Model coverage(%)35.3
Normalized DOPE score-1.736

Model Number2
Model nameRv1641.2
Template2IFE    APDBCREDO
Template coverage91_180
Template Identity(%)41.6
Model coverage(%)43.8
Normalized DOPE score-0.942

Structure Models from Chopin
Model Number1
Profiled.68.1.1 - 3.30.110.10
Click for model details
zscore27.03
Residue begin82
Residue end172
Model Number2
Profiled.15.8.1 - 3.10.20.80
Click for model details
zscore26.06
Residue begin3
Residue end78
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1641Gene nameConfidence Score
Rv1643rplT0.997
Rv3459crpsK0.994
Rv3460crpsM0.992
Rv2890crpsB0.992
Rv0700rpsJ0.989
Rv0721rpsE0.988
Rv0721rpsE0.988
Rv3442crpsI0.987
Rv1642rpmI0.985
Rv3458crpsD0.985
Rv3458crpsD0.985
Rv2882cfrr0.984
Rv0683rpsG0.984
Rv0707rpsC0.984
Rv0707rpsC0.984
Rv0705rpsS0.983
Rv3443crplM0.982
Rv0718rpsH0.982
Rv0682rpsL0.98
Rv2785crpsO0.976
Rv2904crplS0.976
Rv2614cthrS0.972
Rv2614cthrS0.972
Rv2614cthrS0.972
Rv0684fusA10.969
Rv0684fusA10.969
Rv0684fusA10.969
Rv0684fusA10.969
Rv0684fusA10.969
Rv3457crpoA0.967
Rv3457crpoA0.967
Rv3457crpoA0.967
Rv2889ctsf0.966
Rv2889ctsf0.966
Rv1649pheS0.965
Rv1649pheS0.965
Rv2412rpsT0.963
Rv0708rplP0.961
Rv0714rplN0.959
Rv0640rplK0.958
Rv0702rplD0.958
Rv0640rplK0.958
Rv0710rpsQ0.956
Rv0717rpsN10.955
Rv0053rpsF0.955
Rv2909crpsP0.949
Rv0719rplF0.949
Rv2442crplU0.949
Rv0716rplE0.944
Rv0716rplE0.944
Rv0667rpoB0.943
Rv0704rplB0.943
Rv0667rpoB0.943
Rv0667rpoB0.943
Rv0667rpoB0.943
Rv0667rpoB0.943
Rv0667rpoB0.943
Rv0704rplB0.943
Rv0720rplR0.941
Rv0701rplC0.94
Rv0652rplL0.939
Rv0350dnaK0.935
Rv0641rplA0.935
Rv1406fmt0.932
Rv1406fmt0.932
Rv0723rplO0.931
Rv2441crpmA0.925
Rv2906ctrmD0.924
Rv0056rplI0.92
Rv0056rplI0.92
Rv0732secY0.919
Rv0651rplJ0.917
Rv0120cfusA20.916
Rv0120cfusA20.916
Rv0120cfusA20.916
Rv0120cfusA20.916
Rv0120cfusA20.916
Rv1630rpsA0.915
Rv2916cffh0.913
Rv2916cffh0.913
Rv2916cffh0.913
Rv3456crplQ0.912
Rv0639nusG0.907
Rv0639nusG0.907
Rv2462ctig0.906
Rv2462ctig0.906
Rv2462ctig0.906
Rv0715rplX0.905
Rv1699pyrG0.904
Rv1699pyrG0.904
Rv2572caspS0.904
Rv2839cinfB0.904
Rv2572caspS0.904
Rv2839cinfB0.904
Rv2572caspS0.904
Rv2839cinfB0.904
Rv2839cinfB0.904
Rv0706rplV0.902
Potential ligand/drug binding sites
Protein ModelPocket NumberDrug Binding Site PMIN ScorePvalue PMINPMAX ScorePvalue PMAX
Rv1641.231xkk_FMM_A_91PDBCREDO0.7290.0610.5110.009
Rv1641.232xkw_P1B_A_1478PDBCREDO0.7090.0740.5110.009
Rv1641.233bjw_SVR_B_501PDBCREDO0.7140.0710.5010.011
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions