Rv1699

Tuberculist information
Gene namepyrG
Protein functionProbable CTP synthase PyrG
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1923.83
Molecular mass(da)63603
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 586
	  		  	1    VRKHPQTATKHLFVSGGVASSLGKGLTASSLGQLLTARGLHVTMQKLDPYLNVDPGTMNP   60
			  	61   FQHGEVFVTEDGAETDLDVGHYERFLDRNLPGSANVTTGQVYSTVIAKERRGEYLGDTVQ  120
			  	121  VIPHITDEIKRRILAMAQPDADGNRPDVVITEIGGTVGDIESQPFLEAARQVRHYLGRED  180
			  	181  VFFLHVSLVPYLAPSGELKTKPTQHSVAALRSIGITPDALILRCDRDVPEALKNKIALMC  240
			  	241  DVDIDGVISTPDAPSIYDIPKVLHREELDAFVVRRLNLPFRDVDWTEWDDLLRRVHEPHE  300
			  	301  TVRIALVGKYVELSDAYLSVAEALRAGGFKHRAKVEICWVASDGCETTSGAAAALGDVHG  360
			  	361  VLIPGGFGIRGIEGKIGAIAYARARGLPVLGLCLGLQCIVIEAARSVGLTNANSAEFDPD  420
			  	421  TPDPVIATMPDQEEIVAGEADLGGTMRLGSYPAVLEPDSVVAQAYQTTQVSERHRHRYEV  480
			  	481  NNAYRDKIAESGLRFSGTSPDGHLVEFVEYPPDRHPFVVGTQAHPELKSRPTRPHPLFVA  540
			  	541  FVGAAIDYKAGELLPVEIPEIPEHTPNGSSHRDGVGQPLPEPASRG

Known structures in the PDB
No Known structures
1 59 117 175 233 291 349 407 465 523 581 Range: 9 to 288  |  Coverage: 47% CTP_synth_N Range: 312 to 544  |  Coverage: 39% GATase Range: 10 to 550  |  Coverage: 92% 1 Range: 262 to 586  |  Coverage: 55% 1
Number of amino acids : 586
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
CTP_synth_NPF064189-288
GATasePF00117312-544
Mtb Structural Proteome models
Model Number1
Model nameRv1699
Template1VCO    APDBCREDO
Template coverage13_548
Template Identity(%)55.3
Model coverage(%)92.2
Normalized DOPE score-0.891

Structure Models from Chopin
Model Number1
Profilec.23.16.1 - 3.40.50.880
Click for model details
zscore19.2
Residue begin262
Residue end586
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1699Gene nameConfidence Score
Rv3396cguaA0.992
Rv3396cguaA0.992
Rv3396cguaA0.992
Rv2445cndkA0.991
Rv0667rpoB0.99
Rv0667rpoB0.99
Rv0667rpoB0.99
Rv0667rpoB0.99
Rv0667rpoB0.99
Rv0667rpoB0.99
Rv0668rpoC0.989
Rv0668rpoC0.989
Rv0668rpoC0.989
Rv0668rpoC0.989
Rv0668rpoC0.989
Rv3457crpoA0.984
Rv3457crpoA0.984
Rv3457crpoA0.984
Rv1023eno0.982
Rv1023eno0.982
Rv2883cpyrH0.975
Rv2540caroF0.972
Rv2404clepA0.97
Rv2404clepA0.97
Rv2404clepA0.97
Rv0382cpyrE0.97
Rv2404clepA0.97
Rv1536ileS0.967
Rv1536ileS0.967
Rv0357cpurA0.961
Rv1021Rv10210.961
Rv1292argS0.96
Rv1292argS0.96
Rv1292argS0.96
Rv2992cgltS0.956
Rv2139pyrD0.956
Rv1380pyrB0.954
Rv1380pyrB0.954
Rv3459crpsK0.953
Rv0721rpsE0.953
Rv0721rpsE0.953
Rv3442crpsI0.951
Rv0704rplB0.951
Rv0704rplB0.951
Rv2889ctsf0.95
Rv2889ctsf0.95
Rv0808purF0.946
Rv0808purF0.946
Rv0716rplE0.946
Rv0716rplE0.946
Rv2904crplS0.946
Rv2448cvalS0.945
Rv2448cvalS0.945
Rv2448cvalS0.945
Rv2584capt0.944
Rv3411cguaB20.944
Rv3411cguaB20.944
Rv2580chisS0.94
Rv2580chisS0.94
Rv0189cilvD0.939
Rv1700Rv17000.938
Rv2534cefp0.937
Rv2534cefp0.937
Rv2534cefp0.937
Rv0714rplN0.936
Rv3100csmpB0.936
Rv2211cgcvT0.932
Rv3443crplM0.932
Rv2211cgcvT0.932
Rv0640rplK0.93
Rv0640rplK0.93
Rv3309cupp0.925
Rv2697cdut0.924
Rv3315ccdd0.923
Rv2121chisG0.922
Rv2121chisG0.922
Rv0701rplC0.922
Rv1017cprsA0.919
Rv1017cprsA0.919
Rv1379pyrR0.919
Rv1420uvrC0.916
Rv1420uvrC0.916
Rv1420uvrC0.916
Rv1420uvrC0.916
Rv1383carA0.915
Rv1383carA0.915
Rv1390rpoZ0.915
Rv2678chemE0.913
Rv2555calaS0.912
Rv2555calaS0.912
Rv2737crecA0.912
Rv2737crecA0.912
Rv2555calaS0.912
Rv1389gmk0.911
Rv0684fusA10.909
Rv0684fusA10.909
Rv0684fusA10.909
Rv3715crecR0.909
Rv0684fusA10.909
Rv3715crecR0.909
Rv3715crecR0.909
Rv0684fusA10.909
Rv3458crpsD0.908
Rv3458crpsD0.908
Rv0683rpsG0.905
Rv1641infC0.904
Rv0957purH0.904
Rv0957purH0.904
Rv1641infC0.904
Rv0719rplF0.903
Rv2614cthrS0.902
Rv2343cdnaG0.902
Rv2343cdnaG0.902
Rv2343cdnaG0.902
Rv2343cdnaG0.902
Rv2614cthrS0.902
Rv2343cdnaG0.902
Rv2614cthrS0.902
Rv2890crpsB0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
cytidine triphosphatePubChem0.991483.156
ara-CTPPubChem0.991483.156
polyglutaminePubChem0.985146.145
adenosine diphosphatePubChem0.973427.201
cytidinePubChem0.95243.217
phosphatePubChem0.93796.9872
uridine triphosphatePubChem0.935484.141
glutamatePubChem0.923147.129
adenosine triphosphatePubChem0.905507.181
hydroxyl radicalsPubChem0.917.0073
protiumPubChem0.92.01576
uridine diphosphatePubChem0.9404.161
glutaminPubChem0.9146.145
cytidine diphosphatePubChem0.9403.176
deuteriumPubChem0.92.01588
H(+)PubChem0.92.01588
cytosine arabinosidePubChem0.859243.217
sulfatePubChem0.84396.0626
hydron sulfatePubChem0.793196.157
cyclopentenyl cytosinePubChem0.786239.228
magnesiumPubChem0.77724.305
orotic acidPubChem0.764156.096
3'-sialyllactosePubChem0.724647.578
uridinePubChem0.723244.201
CMP-NeuAcPubChem0.702614.451
chloridePubChem0.735.453
DB04323PubChem0.7265.287
(2R)-2-amino-3-[[(3R,5R)-5-[(1S)-1-amino-2-hydroxy-2-oxoethyl]-3-isoxazolidinyl]thio]propanoic acidPubChem0.7265.287
iodidePubChem0.7127.912
(4s)-2-Methyl-2,4-PentanediolPubChem0.7118.174
2-methyl-2,4-pentanediolPubChem0.7118.174