Rv2211c

Tuberculist information
Gene namegcvT
Protein functionProbable aminomethyltransferase GcvT (glycine cleavage system T protein)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2476.04
Molecular mass(da)39597
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 379
	  		  	1    VCQQGRPLGWDAVSDVPELIHGPLEDRHRELGASFAEFGGWLMPVSYAGTVSEHNATRTA   60
			  	61   VGLFDVSHLGKALVRGPGAAQFVNSALTNDLGRIGPGKAQYTLCCTESGGVIDDLIAYYV  120
			  	121  SDDEIFLVPNAANTAAVVGALQAAAPGGLSITNLHRSYAVLAVQGPCSTDVLTALGLPTE  180
			  	181  MDYMGYADASYSGVPVRVCRTGYTGEHGYELLPPWESAGVVFDALLAAVSAAGGEPAGLG  240
			  	241  ARDTLRTEMGYPLHGHELSLDISPLQARCGWAVGWRKDAFFGRAALLAEKAAGPRRLLRG  300
			  	301  LRMVGRGVLRPGLAVLVGDETVGVTTSGTFSPTLQVGIGLALIDSDAGIEDGQQINVDVR  360
			  	361  GRAVECQVVCPPFVAVKTR

Known structures in the PDB
No Known structures
1 38 75 112 149 186 223 260 297 334 371 Range: 63 to 272  |  Coverage: 55% GCV_T Range: 278 to 371  |  Coverage: 24% GCV_T_C Range: 19 to 373  |  Coverage: 93% 1 Range: 16 to 356  |  Coverage: 89% 1 Range: 67 to 159  |  Coverage: 24% 2 Range: 17 to 184  |  Coverage: 44% 3 Range: 290 to 371  |  Coverage: 21% 4
Number of amino acids : 379
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
GCV_TPF0157163-272
GCV_T_CPF08669278-371
Mtb Structural Proteome models
Model Number1
Model nameRv2211c
Template1YX2    APDBCREDO
Template coverage2_359
Template Identity(%)40.6
Model coverage(%)93.4
Normalized DOPE score-0.396

Structure Models from Chopin
Model Number1
Profiled.250.1.1
Click for model details
zscore31.82
Residue begin16
Residue end356
Model Number2
Profile3.30.70.1400
Click for model details
zscore24.13
Residue begin67
Residue end159
Model Number3
Profile3.30.1360.120
Click for model details
zscore22.81
Residue begin17
Residue end184
Model Number4
Profile2.40.30.110
Click for model details
zscore11.77
Residue begin290
Residue end371
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2211cGene nameConfidence Score
Rv1826gcvH0.999
Rv1832gcvB0.999
Rv1832gcvB0.999
Rv0070cglyA20.997
Rv1093glyA10.997
Rv3356cfolD0.994
Rv3356cfolD0.994
Rv2964purU0.984
Rv2964purU0.984
Rv2763cdfrA0.981
Rv2764cthyA0.98
Rv0462lpdC0.978
Rv0462lpdC0.978
Rv0462lpdC0.978
Rv2220glnA10.965
Rv2220glnA10.965
Rv0957purH0.963
Rv0957purH0.963
Rv2222cglnA20.952
Rv2222cglnA20.952
Rv2124cmetH0.94
Rv2124cmetH0.94
Rv2124cmetH0.94
Rv2124cmetH0.94
Rv2124cmetH0.94
Rv0956purN0.933
Rv1699pyrG0.932
Rv1699pyrG0.932
Rv2860cglnA40.931
Rv2860cglnA40.931
Rv0794cRv0794c0.926
Rv0794cRv0794c0.926
Rv0794cRv0794c0.926
Rv0811cRv0811c0.926
Rv0811cRv0811c0.926
Rv3303clpdA0.922
Rv3303clpdA0.922
Rv3303clpdA0.922
Rv2476cgdh0.919
Rv0389purT0.908
Rv1406fmt0.905
Rv1406fmt0.905
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
tetrahydrofolatePubChem0.992445.429
H4FPubChem0.968445.429
ammoniaPubChem0.94717.0305
5,10-methylenetetrahydrofolatePubChem0.931457.44
carbon dioxidePubChem0.91644.0095
polyglycinePubChem0.90575.0666
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
5,10-methenyltetrahydrofolatePubChem0.9456.432
N5,N10-methylenetetrahydrofolatePubChem0.9457.44
NAD+PubChem0.9663.425
methenyltetrahydrofolatePubChem0.9456.432
selenomethioninePubChem0.781196.106
SeMetPubChem0.781196.106
5-methyltetrahydrofolatePubChem0.756459.456
methyltetrahydrofolatePubChem0.756459.456
Na(+)PubChem0.72922.9898