Rv0794c

Tuberculist information
Gene nameRv0794c
Protein functionProbable oxidoreductase
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)887.137
Molecular mass(da)52476.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 499
	  		  	1    MTAAQQDQAPMATPGCREGETYDVVVLGAGPVGQNVADRARAGGLRVAVVERELVGGECS   60
			  	61   YWACVPSKALLRPVIAISDARRVDGAREAVDGSINTAGVFGRRNRYVAHWDDTGQADWVS  120
			  	121  GIGATLIRGDGRLDGPRRVVVTKSSGESVALTARHAVVICTGSRPALPDLPGITEARPWT  180
			  	181  NRQATDNSTVPDRLAIVGAGGVGVEMATAWQGLGASVTLLARGSGLLPRMEPFVGELIGR  240
			  	241  GLADAGVDVRVGVSVRALGRPNPTGPVVLELDDGTELRVDEVLFATGRAPRTDDIGLETI  300
			  	301  GLTPGSWLDVDDTCRVRAVDDGWLYAAGDVNHRALLTHQGKYQARIAGTAIGARAAGRPL  360
			  	361  DTTSWGMHATTADHHAVPQAFFTDPEAAAVGLTADQAAQAGHRIKAIDVEIGDVVMGAKL  420
			  	421  FADGYTGRARMVVDVDRGHLLGVTMVGPGAAELLHSATVAVAGQVPIDRLWHAVPCFPTI  480
			  	481  SELWLRLLESYRDSFYLLV

Known structures in the PDB
No Known structures
1 50 99 148 197 246 295 344 393 442 491 Range: 23 to 334  |  Coverage: 62% Pyr_redox_2 Range: 193 to 274  |  Coverage: 16% Pyr_redox Range: 377 to 487  |  Coverage: 22% Pyr_redox_dim Range: 22 to 482  |  Coverage: 92% 1 Range: 16 to 499  |  Coverage: 96% 1 Range: 319 to 499  |  Coverage: 36% 2 Range: 377 to 487  |  Coverage: 22% 3 Range: 134 to 291  |  Coverage: 31% 4
Number of amino acids : 499
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Pyr_redox_2PF0799223-334
Pyr_redoxPF00070193-274
Pyr_redox_dimPF02852377-487
Mtb Structural Proteome models
Model Number1
Model nameRv0794c
Template2A8X    APDBCREDO
Template coverage4_448
Template Identity(%)32.1
Model coverage(%)92.2
Normalized DOPE score0.141

Structure Models from Chopin
Model Number1
Profilec.3.1.5, d.87.1.1
Click for model details
zscore63.72
Residue begin16
Residue end499
Model Number2
Profiled.87.1.1
Click for model details
zscore12.24
Residue begin319
Residue end499
Model Number3
Profile3.30.390.30
Click for model details
zscore10.44
Residue begin377
Residue end487
Model Number4
Profilec.3.1.5
Click for model details
zscore9.37
Residue begin134
Residue end291
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0794cGene nameConfidence Score
Rv2495cbkdC0.963
Rv2495cbkdC0.963
Rv2495cbkdC0.963
Rv2496cbkdB0.962
Rv2215dlaT0.962
Rv2496cbkdB0.962
Rv2215dlaT0.962
Rv2215dlaT0.962
Rv2497cbkdA0.947
Rv2211cgcvT0.926
Rv2211cgcvT0.926
Rv1832gcvB0.922
Rv1832gcvB0.922
Rv0843Rv08430.921
Rv2241aceE0.913
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
mercuryPubChem0.924200.59
NAD+PubChem0.919663.425
lipoamidePubChem0.917205.341
NADP(H)PubChem0.912745.421
dihydrolipoamidePubChem0.908207.357
NADPPubChem0.907744.413
oxidized glutathionePubChem0.903612.631
reduced glutathionePubChem0.903307.323
reduced nicotinamide adenine dinucleotidePubChem0.903665.441
acetyl-CoAPubChem0.901809.571
coenzyme APubChem0.9767.534
oxidized-glutathionePubChem0.9612.631
LPMPubChem0.9207.357
DL-lipoamidePubChem0.9205.341
NSC647529PubChem0.9307.323
carbon dioxidePubChem0.944.0095
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
pyruvic acidPubChem0.988.0621
Co-APubChem0.9767.534
deuteriumPubChem0.92.01588
protiumPubChem0.92.01576
acetyl coenzyme-APubChem0.9809.571
H(+)PubChem0.92.01588