Rv2497c

Tuberculist information
Gene namebkdA
Protein functionProbable branched-chain keto acid dehydrogenase E1 component, alpha subunit BkdA
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2810.99
Molecular mass(da)40615.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 367
	  		  	1    MGEGSRRPSGMLMSVDLEPVQLVGPDGTPTAERRYHRDLPEETLRWLYEMMVVTRELDTE   60
			  	61   FVNLQRQGELALYTPCRGQEAAQVGAAACLRKTDWLFPQYRELGVYLVRGIPPGHVGVAW  120
			  	121  RGTWHGGLQFTTKCCAPMSVPIGTQTLHAVGAAMAAQRLDEDSVTVAFLGDGATSEGDVH  180
			  	181  EALNFAAVFTTPCVFYVQNNQWAISMPVSRQTAAPSIAHKAIGYGMPGIRVDGNDVLACY  240
			  	241  AVMAEAAARARAGDGPTLIEAVTYRLGPHTTADDPTRYRSQEEVDRWATLDPIPRYRTYL  300
			  	301  QDQGLWSQRLEEQVTARAKHVRSELRDAVFDAPDFDVDEVFTTVYAEITPGLQAQREQLR  360
			  	361  AELARTD

Known structures in the PDB
No Known structures
1 37 73 109 145 181 217 253 289 325 361 Range: 48 to 338  |  Coverage: 79% E1_dh Range: 18 to 363  |  Coverage: 94% 1 Range: 1 to 367  |  Coverage: 99% 1
Number of amino acids : 367
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
E1_dhPF0067648-338
Mtb Structural Proteome models
Model Number1
Model nameRv2497c
Template1UMD    APDBCREDO
Template coverage14_367
Template Identity(%)40.5
Model coverage(%)94.0
Normalized DOPE score-0.784

Structure Models from Chopin
Model Number1
Profilec.36.1.10
Click for model details
zscore7.32
Residue begin1
Residue end367
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2497cGene nameConfidence Score
Rv2496cbkdB0.999
Rv2496cbkdB0.999
Rv2495cbkdC0.999
Rv2495cbkdC0.999
Rv2495cbkdC0.999
Rv2215dlaT0.998
Rv2215dlaT0.998
Rv2215dlaT0.998
Rv0462lpdC0.996
Rv0462lpdC0.996
Rv0462lpdC0.996
Rv3303clpdA0.976
Rv3303clpdA0.976
Rv3303clpdA0.976
Rv1617pykA0.954
Rv1617pykA0.954
Rv0794cRv0794c0.947
Rv0794cRv0794c0.947
Rv0794cRv0794c0.947
Rv2967cpca0.943
Rv2332mez0.943
Rv2967cpca0.943
Rv2332mez0.943
Rv2967cpca0.943
Rv2967cpca0.943
Rv2967cpca0.943
Rv2967cpca0.943
Rv3003cilvB10.935
Rv3003cilvB10.935
Rv3003cilvB10.935
Rv0843Rv08430.934
Rv2241aceE0.926
Rv3667acs0.922
Rv3667acs0.922
Rv1127cppdK0.913
Rv1127cppdK0.913
Rv0752cfadE90.911
Rv0752cfadE90.911
Rv0752cfadE90.911
Rv1872clldD20.91
Rv3002cilvN0.909
Rv3002cilvN0.909
Rv1820ilvG0.905
Rv1820ilvG0.905
Rv1820ilvG0.905
Rv1449ctkt0.903
Rv1449ctkt0.903
Rv1449ctkt0.903
Rv0694lldD10.903
Rv3470cilvB20.901
Rv3470cilvB20.901
Rv3470cilvB20.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
thiamine pyrophosphatePubChem0.987425.314
alpha-ketoisocaproatePubChem0.974130.142
isobutyryl-CoAPubChem0.946837.624
acetyl-CoAPubChem0.941809.571
isobutyryl coenzyme APubChem0.929837.624
coenzyme APubChem0.921767.534
lipoamidePubChem0.918205.341
alpha-ketoisovaleratePubChem0.917116.115
2-methylbutyryl-CoAPubChem0.915851.651
phosphoenolpyruvatePubChem0.908168.042
isovaleryl-CoAPubChem0.907851.651
adenosine triphosphatePubChem0.907507.181
NAD+PubChem0.905663.425
pyruvic acidPubChem0.90188.0621
deuteriumPubChem0.92.01588
Co-APubChem0.9767.534
6-S-acetyldihydrolipoamidePubChem0.9249.393
C05125PubChem0.9469.367
adenosine diphosphatePubChem0.9427.201
DL-lipoamidePubChem0.9205.341
carbon dioxidePubChem0.944.0095
acetyl coenzyme-APubChem0.9809.571
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
alpha-keto-beta-methylvaleric acidPubChem0.9130.142
flavin adenine dinucleotidePubChem0.9785.55
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
3-methylbutyryl-CoAPubChem0.9851.651
protiumPubChem0.92.01576
CHEBI:15477PubChem0.9851.651
H(+)PubChem0.92.01588
magnesiumPubChem0.77824.305