Rv0752c

Tuberculist information
Gene namefadE9
Protein functionProbable acyl-CoA dehydrogenase FadE9
Functional category(tuberculist)lipid metabolism
Gene location(kb)843.242
Molecular mass(da)41451.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 390
	  		  	1    MFVLNDDERVIVETAAAFAGKRLAPHALEWDAAKHFPVDVLREAAELGMAAIYCRDDVGG   60
			  	61   SGLRRLDGVRIFEQLAIADPVTAAFLSIHNMCAWMIDSFGTDEQRKDWIPRLATMGVIAS  120
			  	121  YCLTEPGAGSDAGALSTRAVRHGSGKGGDYVLDGVKQFISGAAASDVYVVMARTGAEGPR  180
			  	181  GVSAFIVEKGTPGLSFGAPEAKMGWHAQPTAQVVLDGVRVPAEAMLGGADGEGAGFGIAM  240
			  	241  SGLNGGRLNIAACSLGGAQAAFDKAGAYVRDRQAFGGSLLDEPTVRFTLADMATGLQTSR  300
			  	301  MLLWRAASALDDDDADKVELCAMAKRYVTDTCFEVADQALQLHGGYGYLREYGLEKIVRD  360
			  	361  LRVHRILEGTNEIMRLVIGRAEAARFRATV

Known structures in the PDB
No Known structures
1 40 79 118 157 196 235 274 313 352 391 Range: 5 to 116  |  Coverage: 28% Acyl-CoA_dh_N Range: 120 to 175  |  Coverage: 14% Acyl-CoA_dh_M Range: 233 to 383  |  Coverage: 38% Acyl-CoA_dh_1 Range: 4 to 385  |  Coverage: 97% 1 Range: 1 to 390  |  Coverage: 99% 1 Range: 233 to 383  |  Coverage: 38% 2 Range: 5 to 116  |  Coverage: 28% 3 Range: 1 to 233  |  Coverage: 59% 4
Number of amino acids : 390
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Acyl-CoA_dh_NPF027715-116
Acyl-CoA_dh_MPF02770120-175
Acyl-CoA_dh_1PF00441233-383
Mtb Structural Proteome models
Model Number1
Model nameRv0752c
Template1RX0    APDBCREDO
Template coverage19_393
Template Identity(%)52.8
Model coverage(%)97.7
Normalized DOPE score-1.1

Structure Models from Chopin
Model Number1
Profilea.29.3.1, e.6.1.1 - 1.10.540.10, 1.20.140.10, 2.40.110.10
Click for model details
zscore66.71
Residue begin1
Residue end390
Model Number2
Profilea.29.3.1
Click for model details
zscore37.96
Residue begin233
Residue end383
Model Number3
Profile1.10.540.10
Click for model details
zscore23.91
Residue begin5
Residue end116
Model Number4
Profilee.6.1.1
Click for model details
zscore15.99
Residue begin1
Residue end233
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0752cGene nameConfidence Score
Rv1071cechA90.973
Rv1071cechA90.973
Rv3774echA210.971
Rv0751cmmsB0.93
Rv0751cmmsB0.93
Rv0860fadB0.93
Rv0860fadB0.93
Rv0860fadB0.93
Rv2790cltp10.929
Rv2790cltp10.929
Rv1070cechA80.928
Rv2496cbkdB0.926
Rv2496cbkdB0.926
Rv2495cbkdC0.92
Rv2495cbkdC0.92
Rv2495cbkdC0.92
Rv0462lpdC0.912
Rv0462lpdC0.912
Rv0462lpdC0.912
Rv3552Rv35520.911
Rv0753cmmsA0.911
Rv3561fadD30.911
Rv2497cbkdA0.911
Rv3561fadD30.911
Rv3551Rv35510.91
Rv0166fadD50.909
Rv0166fadD50.909
Rv0222echA10.908
Rv3516echA190.905
Rv1058fadD140.903
Rv1058fadD140.903
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
flavin adenine dinucleotidePubChem0.955785.55
isobutyryl-CoAPubChem0.917837.624
2MCPubChem0.914835.608
coenzyme APubChem0.908767.534
formatePubChem0.90645.0174
adenosine monophosphatePubChem0.901347.221
naphthyl-2-methyl-succinyl-CoAPubChem0.91007.79
Co-APubChem0.9767.534
c1137PubChem0.9875.672
isobutyryl coenzyme APubChem0.9837.624
deuteriumPubChem0.92.01588
C16468PubChem0.9875.672
NSC112207PubChem0.9785.55
adenosine triphosphatePubChem0.9507.181
pyrophosphatePubChem0.9177.975
H(+)PubChem0.92.01588
5-methylhex-4-enoyl-CoAPubChem0.9877.688
FADH2PubChem0.9787.566
1,5-dihydro-FADPubChem0.9787.566
protiumPubChem0.92.01576
hydroxyl radicalsPubChem0.917.0073
AR-1A9122PubChem0.9787.566