Tuberculist information
Gene namefadD14
Protein functionProbable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)
Functional category(tuberculist)lipid metabolism
Gene location(kb)1180.68
Molecular mass(da)59624.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 543
	  		  	1    MYGTMQDFPLTITAIMRHGCGVHGRRTVTTATGEGYRHSSYRDVGQRAGQLANALRRLGV   60
			  	61   TGDQRVATFMWNNTEHLVTYFAVPSMGAVLHTLNIRLFPEQIAYVTNEAEDRVILVDLSL  120
			  	121  ARLLAPVLPKLDTVHTVIAVGEGDTTPLREAGKTVLRFAELIDAESPDFGWPQIDENSAA  180
			  	181  AMCYTSGTTGNPKGVVYSHRSSFLHTMAACTTNGIGVGSSDKVLPIVPMFHANGWGLPYA  240
			  	241  ALMAGADLVLPDRHLDARSLIHMVETLKPTLAGAVPTIWNDVMHYLEKDPDHDMSSLRLV  300
			  	301  ACGGSAVPESLMRTFEDKHDVQIRQLWGMTETSPLATMAWPPPGTPDDQHWAFRITQGQP  360
			  	361  VCGVETRIVDDDGQVLPNDGNAVGEVEVRGPWIAGSYYGGRDESKFDSGWLRTGDVGRID  420
			  	421  EQGFITLTDRAKDVIKSGGEWISSVELENCLIAHPDVLEAAVVGVPDERWQERPLAVVVV  480
			  	481  REGATVSAGDLRAFLADKVVRWWLPERWAFVDEIPRTSVGKYDKKAIRSRYAEGAYQITE  540
			  	541  VHT
			  			

Known structures in the PDB
No Known structures
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
AMP-bindingPF0050117-438
AMP-binding_CPF13193446-521
Mtb Structural Proteome models
Model Number1
Model nameRv1058
Template1V25    APDBCREDO
Template coverage11_536
Template Identity(%)42.6
Model coverage(%)97.6
Normalized DOPE score-0.485

Structure Models from Chopin
Model Number1
Profilee.23.1.1
Click for model details
zscore53.71
Residue begin1
Residue end543
Model Number2
Profile3.30.300.30
Click for model details
zscore13.06
Residue begin429
Residue end538
Model Number3
Profile2.30.38.10
Click for model details
zscore12.2
Residue begin358
Residue end430
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1058Gene nameConfidence Score
Rv1934cfadE170.914
Rv1934cfadE170.914
Rv1934cfadE170.914
Rv2724cfadE200.911
Rv2724cfadE200.911
Rv2724cfadE200.911
Rv0244cfadE50.909
Rv0244cfadE50.909
Rv0244cfadE50.909
Rv0244cfadE50.909
Rv0244cfadE50.909
Rv1467cfadE150.907
Rv1467cfadE150.907
Rv1467cfadE150.907
Rv1467cfadE150.907
Rv1467cfadE150.907
Rv0975cfadE130.905
Rv3274cfadE250.905
Rv2500cfadE190.905
Rv3274cfadE250.905
Rv3564fadE330.905
Rv2500cfadE190.905
Rv3274cfadE250.905
Rv0975cfadE130.905
Rv3564fadE330.905
Rv2500cfadE190.905
Rv0975cfadE130.905
Rv0215cfadE30.903
Rv3560cfadE300.903
Rv0752cfadE90.903
Rv0752cfadE90.903
Rv0752cfadE90.903
Rv0215cfadE30.903
Rv3560cfadE300.903
Rv0215cfadE30.903
Rv3560cfadE300.903
Rv3504fadE260.902
Rv3797fadE350.902
Rv3504fadE260.902
Rv3504fadE260.902
Rv3797fadE350.902
Rv0672fadE80.901
Rv0131cfadE10.901
Rv3563fadE320.901
Rv3543cfadE290.901
Rv0131cfadE10.901
Rv3563fadE320.901
Rv3543cfadE290.901
Rv0131cfadE10.901
Rv3543cfadE290.901
Rv0672fadE80.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
adenosine monophosphatePubChem0.929347.221
coenzyme APubChem0.911767.534
H(+)PubChem0.92.01588
1,5-dihydro-FADPubChem0.9787.566
FADH2PubChem0.9787.566
pyrophosphatePubChem0.9177.975
formatePubChem0.945.0174
AR-1A9122PubChem0.9787.566
flavin adenine dinucleotidePubChem0.9785.55
Co-APubChem0.9767.534
deuteriumPubChem0.92.01588
protiumPubChem0.92.01576
adenosine triphosphatePubChem0.9507.181
NSC112207PubChem0.9785.55