Rv2724c

Tuberculist information
Gene namefadE20
Protein functionProbable acyl-CoA dehydrogenase FadE20
Functional category(tuberculist)lipid metabolism
Gene location(kb)3036.13
Molecular mass(da)42844.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 386
	  		  	1    MGSATKYQRTLFEPEHELFRESYRAFLDRHVAPYHDEWEKTKIVDRGVWLEAGKQGFLGM   60
			  	61   AVPEEYGGGGNADFRYNTVITEETCAGRYSGIGFGLHNDIVAPYLLALATEEQKRRWFPN  120
			  	121  FCTGELITAIAMTEPGTGSDLQGITTRAVKHGDHYVLNGSKTFITNGINSDLVIVVAQTD  180
			  	181  PEKGAQGFSLLVVERGMAGFERGRQLDKIGLDAQDTAELSFTDVAVPAENLLGQEGMGFI  240
			  	241  YLMQNLPQERISIAIMAAAGMESVLEQTLQYAKERKAFGRSIGSFQNSRFLLAELATEAT  300
			  	301  VVRIMVDEFIKLHLAGKLTAEQAAMAKWYATEKQVYLNDRCLQLHGGYGYMREYPVARAY  360
			  	361  LDSRVQTIYGGTTEIMKEIIGRGLGV

Known structures in the PDB
No Known structures
1 39 77 115 153 191 229 267 305 343 381 Range: 13 to 125  |  Coverage: 29% Acyl-CoA_dh_N Range: 129 to 180  |  Coverage: 13% Acyl-CoA_dh_M Range: 236 to 385  |  Coverage: 38% Acyl-CoA_dh_1 Range: 12 to 384  |  Coverage: 96% 1 Range: 7 to 386  |  Coverage: 98% 1 Range: 236 to 385  |  Coverage: 38% 2 Range: 1 to 239  |  Coverage: 61% 3 Range: 13 to 125  |  Coverage: 29% 4 Range: 126 to 248  |  Coverage: 31% 5
Number of amino acids : 386
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Acyl-CoA_dh_NPF0277113-125
Acyl-CoA_dh_MPF02770129-180
Acyl-CoA_dh_1PF00441236-385
Mtb Structural Proteome models
Model Number1
Model nameRv2724c
Template1BUC    APDBCREDO
Template coverage5_381
Template Identity(%)34.0
Model coverage(%)96.4
Normalized DOPE score-0.983

Structure Models from Chopin
Model Number1
Profile1.20.140.10, 2.40.110.10
Click for model details
zscore67.74
Residue begin7
Residue end386
Model Number2
Profilea.29.3.1
Click for model details
zscore31.74
Residue begin236
Residue end385
Model Number3
Profilee.6.1.1
Click for model details
zscore21.99
Residue begin1
Residue end239
Model Number4
Profile1.10.540.10
Click for model details
zscore18.76
Residue begin13
Residue end125
Model Number5
Profile2.40.110.10
Click for model details
zscore17.98
Residue begin126
Residue end248
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2724cGene nameConfidence Score
Rv3774echA210.975
Rv0860fadB0.973
Rv0860fadB0.973
Rv0860fadB0.973
Rv0243fadA20.939
Rv0243fadA20.939
Rv2790cltp10.934
Rv2790cltp10.934
Rv1071cechA90.931
Rv1071cechA90.931
Rv1070cechA80.926
Rv3140fadE230.913
Rv3140fadE230.913
Rv3552Rv35520.911
Rv3561fadD30.911
Rv3561fadD30.911
Rv1058fadD140.911
Rv1058fadD140.911
Rv3551Rv35510.91
Rv0166fadD50.91
Rv0166fadD50.91
Rv0222echA10.909
Rv3516echA190.906
Rv3039cechA170.903
Rv0971cechA70.903
Rv1142cechA100.902
Rv1472echA120.902
Rv2831echA160.901
Rv1141cechA110.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
flavin adenine dinucleotidePubChem0.947785.55
coenzyme APubChem0.946767.534
myristoyl-CoAPubChem0.906977.89
formatePubChem0.90545.0174
acetyl-CoAPubChem0.905809.571
lauroyl-CoAPubChem0.901949.837
4-cis-decenoyl-CoAPubChem0.9919.768
H(+)PubChem0.92.01588
CHEBI:27721PubChem0.9975.874
c1137PubChem0.9875.672
lauroyl-coenzyme APubChem0.9949.837
naphthyl-2-methyl-succinyl-CoAPubChem0.91007.79
C16468PubChem0.9875.672
deuteriumPubChem0.92.01588
AcCoAPubChem0.9809.571
C05279PubChem0.9945.805
adenosine monophosphatePubChem0.9347.221
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
CHEBI:15471PubChem0.9947.821
C03221PubChem0.9947.821
AR-1A9122PubChem0.9787.566
pyrophosphatePubChem0.9177.975
CHEBI:28002PubChem0.9945.805
5-methylhex-4-enoyl-CoAPubChem0.9877.688
18:2(n-6)PubChem0.91029.96
Co-APubChem0.9767.534
CHEBI:28387PubChem0.9945.805
1,5-dihydro-FADPubChem0.9787.566
FADH2PubChem0.9787.566
C05273PubChem0.9975.874
NAD+PubChem0.9663.425
protiumPubChem0.92.01576
C05280PubChem0.9945.805
adenosine triphosphatePubChem0.9507.181
NSC112207PubChem0.9785.55
hydroxyl radicalsPubChem0.917.0073
CHEBI:57385PubChem0.9977.89