Rv0166

Tuberculist information
Gene namefadD5
Protein functionProbable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)
Functional category(tuberculist)lipid metabolism
Gene location(kb)194.993
Molecular mass(da)59887.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 554
	  		  	1    LTAQLASHLTRALTLAQQQPYLARRQNWVNQLERHAMMQPDAPALRFVGNTMTWADLRRR   60
			  	61   VAALAGALSGRGVGFGDRVMILMLNRTEFVESVLAANMIGAIAVPLNFRLTPTEIAVLVE  120
			  	121  DCVAHVMLTEAALAPVAIGVRNIQPLLSVIVVAGGSSQDSVFGYEDLLNEAGDVHEPVDI  180
			  	181  PNDSPALIMYTSGTTGRPKGAVLTHANLTGQAMTALYTSGANINSDVGFVGVPLFHIAGI  240
			  	241  GNMLTGLLLGLPTVIYPLGAFDPGQLLDVLEAEKVTGIFLVPAQWQAVCTEQQARPRDLR  300
			  	301  LRVLSWGAAPAPDALLRQMSATFPETQILAAFGQTEMSPVTCMLLGEDAIAKRGSVGRVI  360
			  	361  PTVAARVVDQNMNDVPVGEVGEIVYRAPTLMSCYWNNPEATAEAFAGGWFHSGDLVRMDS  420
			  	421  DGYVWVVDRKKDMIISGGENIYCAELENVLASHPDIAEVAVIGRADEKWGEVPIAVAAVT  480
			  	481  NDDLRIEDLGEFLTDRLARYKHPKALEIVDALPRNPAGKVLKTELRLRYGACVNVERRSA  540
			  	541  SAGFTERRENRQKL

Known structures in the PDB
No Known structures
1 56 111 166 221 276 331 386 441 496 551 Range: 32 to 437  |  Coverage: 73% AMP-binding Range: 445 to 519  |  Coverage: 13% AMP-binding_C Range: 19 to 533  |  Coverage: 92% 1 Range: 1 to 548  |  Coverage: 98% 1 Range: 357 to 429  |  Coverage: 12% 2 Range: 428 to 536  |  Coverage: 19% 3
Number of amino acids : 554
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
AMP-bindingPF0050132-437
AMP-binding_CPF13193445-519
Mtb Structural Proteome models
Model Number1
Model nameRv0166
Template2D1S    APDBCREDO
Template coverage15_545
Template Identity(%)26.0
Model coverage(%)92.8
Normalized DOPE score-0.447

Structure Models from Chopin
Model Number1
Profilee.23.1.1
Click for model details
zscore59.12
Residue begin1
Residue end548
Model Number2
Profile2.30.38.10
Click for model details
zscore19.01
Residue begin357
Residue end429
Model Number3
Profile3.30.300.30
Click for model details
zscore10.14
Residue begin428
Residue end536
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0166Gene nameConfidence Score
Rv3139fadE240.92
Rv3139fadE240.92
Rv3139fadE240.92
Rv2500cfadE190.91
Rv2500cfadE190.91
Rv2724cfadE200.91
Rv2724cfadE200.91
Rv2724cfadE200.91
Rv2500cfadE190.91
Rv0752cfadE90.909
Rv0752cfadE90.909
Rv0752cfadE90.909
Rv0215cfadE30.908
Rv0215cfadE30.908
Rv0215cfadE30.908
Rv0244cfadE50.907
Rv0244cfadE50.907
Rv0244cfadE50.907
Rv0244cfadE50.907
Rv0975cfadE130.907
Rv0244cfadE50.907
Rv0975cfadE130.907
Rv0975cfadE130.907
Rv0167yrbE1A0.906
Rv1467cfadE150.905
Rv1467cfadE150.905
Rv1467cfadE150.905
Rv1467cfadE150.905
Rv1467cfadE150.905
Rv3274cfadE250.903
Rv3274cfadE250.903
Rv3274cfadE250.903
Rv3797fadE350.902
Rv3797fadE350.902
Rv3140fadE230.902
Rv3140fadE230.902
Rv0672fadE80.902
Rv0672fadE80.902
Rv0178Rv01780.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
coenzyme APubChem0.915767.534
adenosine monophosphatePubChem0.908347.221
adenosine triphosphatePubChem0.905507.181
Co-APubChem0.902767.534
pyrophosphatePubChem0.901177.975
H(+)PubChem0.92.01588
1,5-dihydro-FADPubChem0.9787.566
FADH2PubChem0.9787.566
formatePubChem0.945.0174
AR-1A9122PubChem0.9787.566
flavin adenine dinucleotidePubChem0.9785.55
deuteriumPubChem0.92.01588
protiumPubChem0.92.01576
NSC112207PubChem0.9785.55