SInCRe - Rv0167

Tuberculist information

Gene name	yrbE1A
Protein function	Conserved integral membrane protein YrbE1A
Functional category(tuberculist)	virulence,detoxification and adaptaion
Gene location(kb)	196.861
Molecular mass(da)	27743.1
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 265

	  		  	1    VTTSTTLGGYVRDQLQTPLTLVGGFFRMCVLTGKALFRWPFQWREFILQCWFIMRVGFLP   60
			  	61   TIMVSIPLTVLLIFTLNILLAQFGAADISGSGAAIGAVTQLGPLTTVLVVAGAGSTAICA  120
			  	121  DLGARTIREEIDAMEVLGIDPIHRLVVPRVLASMLVATLLNGLVITVGLVGGFLFGVYLQ  180
			  	181  NVSGGAYLATLTLITGLPEVVIATIKAATFGLIAGLVGCYRGLTVRGGSKGLGTAVNETV  240
			  	241  VLCVIALFAVNVILTTIGVRFGTGR

Known structures in the PDB

No Known structures

Number of amino acids : 265

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
Permease	PF02405	44-258

Mtb Structural Proteome models

Model Number	1
Model name	Rv0167.2
Template	1YO8 APDB CREDO
Template coverage	1013_1170
Template Identity(%)	10.4
Model coverage(%)	54.0
Normalized DOPE score	1.289

Model Number	2
Model name	Rv0167
Template	1YO8 APDB CREDO
Template coverage	971_1171
Template Identity(%)	9.5
Model coverage(%)	85.3
Normalized DOPE score	1.594

Structure Models from Chopin

CHOPIN models not available for this query

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv0167	Gene name	Confidence Score
Rv0170	mce1B	0.993
Rv0170	mce1B	0.993
Rv0174	mce1F	0.98
Rv0169	mce1A	0.968
Rv0169	mce1A	0.968
Rv0171	mce1C	0.958
Rv0178	Rv0178	0.953
Rv0175	Rv0175	0.949
Rv0168	yrbE1B	0.94
Rv0166	fadD5	0.906
Rv0166	fadD5	0.906

Potential ligand/drug binding sites

Protein Model	Pocket Number	Drug Binding Site	PMIN Score	Pvalue PMIN	PMAX Score	Pvalue PMAX
Rv0167.2	1	1err_RAL_B_600 PDB CREDO	0.695	0.085	0.695	0.000
Rv0167.2	1	1err_RAL_A_600 PDB CREDO	0.692	0.087	0.692	0.000
Rv0167.2	1	2jfa_RAL_B_600 PDB CREDO	0.688	0.090	0.688	0.000
Rv0167.2	1	3ogp_017_A_200 PDB CREDO	0.725	0.063	0.682	0.000
Rv0167.2	1	2jfa_RAL_A_600 PDB CREDO	0.675	0.102	0.654	0.001
Rv0167.2	1	3heg_BAX_A_1 PDB CREDO	0.679	0.098	0.639	0.001
Rv0167.2	1	3ogp_017_B_200 PDB CREDO	0.735	0.057	0.633	0.001
Rv0167.2	1	1n49_RIT_D_401 PDB CREDO	0.734	0.057	0.632	0.001
Rv0167.2	1	2qxs_RAL_B_600 PDB CREDO	0.820	0.018	0.631	0.001
Rv0167.2	1	2qxs_RAL_A_600 PDB CREDO	0.819	0.018	0.631	0.001
Rv0167.2	1	3so9_017_A_100 PDB CREDO	0.641	0.133	0.622	0.001
Rv0167.2	1	2r5q_1UN_D_900 PDB CREDO	0.699	0.082	0.620	0.001
Rv0167.2	1	2o4n_TPV_A_300 PDB CREDO	0.636	0.139	0.617	0.002
Rv0167.2	1	2r5q_1UN_B_900 PDB CREDO	0.694	0.086	0.615	0.002
Rv0167.2	1	2pl0_STI_A_200 PDB CREDO	0.653	0.121	0.615	0.002
Rv0167.2	1	3el0_1UN_A_201 PDB CREDO	0.754	0.045	0.614	0.002
Rv0167.2	1	3lzv_017_A_200 PDB CREDO	0.751	0.047	0.612	0.002
Rv0167.2	1	1d4y_TPV_A_501 PDB CREDO	0.628	0.147	0.609	0.002
Rv0167.2	1	3h52_486_A_3 PDB CREDO	0.628	0.147	0.609	0.002
Rv0167.2	1	3gcs_BAX_A_401 PDB CREDO	0.665	0.110	0.607	0.002
Rv0167.2	1	1t7j_478_A_200 PDB CREDO	0.621	0.155	0.602	0.002
Rv0167.2	1	3spk_TPV_B_100 PDB CREDO	0.675	0.101	0.598	0.002
Rv0167.2	1	2oiq_STI_A_1001 PDB CREDO	0.631	0.144	0.594	0.002
Rv0167.2	1	1n49_RIT_B_301 PDB CREDO	0.749	0.048	0.593	0.002
Rv0167.2	1	1qkn_RAL_A_600 PDB CREDO	0.648	0.126	0.589	0.003
Rv0167.2	1	4asd_BAX_A_1500 PDB CREDO	0.644	0.131	0.588	0.003
Rv0167.2	1	3ufn_ROC_A_401 PDB CREDO	0.823	0.017	0.585	0.003
Rv0167.2	1	3oez_STI_B_601 PDB CREDO	0.603	0.175	0.585	0.003
Rv0167.2	1	3s56_ROC_A_201 PDB CREDO	0.779	0.033	0.584	0.003
Rv0167.2	1	2rkg_AB1_B_501 PDB CREDO	0.599	0.181	0.580	0.003
Rv0167.2	1	2o4p_TPV_A_300 PDB CREDO	0.653	0.122	0.579	0.003
Rv0167.2	1	1mui_AB1_B_100 PDB CREDO	0.595	0.185	0.577	0.003
Rv0167.2	1	3ekq_ROC_A_100 PDB CREDO	0.747	0.050	0.575	0.003
Rv0167.2	1	3erd_DES_B_800 PDB CREDO	0.773	0.036	0.573	0.003
Rv0167.2	1	1sgu_MK1_B_2632 PDB CREDO	0.663	0.112	0.571	0.004
Rv0167.2	1	3oez_STI_A_601 PDB CREDO	0.663	0.112	0.571	0.004
Rv0167.2	1	3h52_486_D_2 PDB CREDO	0.586	0.197	0.568	0.004
Rv0167.2	1	3h52_486_B_1 PDB CREDO	0.602	0.176	0.567	0.004
Rv0167.2	1	2hyy_STI_B_600 PDB CREDO	0.602	0.177	0.566	0.004
Rv0167.2	1	3ebz_017_B_201 PDB CREDO	0.637	0.137	0.565	0.004
Rv0167.2	1	3bbt_FMM_D_91 PDB CREDO	0.686	0.092	0.564	0.004
Rv0167.2	1	3gp0_NIL_A_1 PDB CREDO	0.792	0.028	0.563	0.004
Rv0167.2	1	3oy4_017_B_200 PDB CREDO	0.635	0.140	0.563	0.004
Rv0167.2	1	2aoh_FRD_C_305 PDB CREDO	0.598	0.181	0.563	0.004
Rv0167.2	1	3u7s_017_A_202 PDB CREDO	0.599	0.180	0.562	0.004
Rv0167.2	1	3cs9_NIL_A_600 PDB CREDO	0.708	0.075	0.561	0.004
Rv0167.2	1	1hsh_MK1_A_401 PDB CREDO	0.744	0.051	0.557	0.004
Rv0167.2	1	2w8y_486_A_1000 PDB CREDO	0.610	0.168	0.557	0.004
Rv0167.2	1	1c6y_MK1_B_524 PDB CREDO	0.741	0.053	0.556	0.005
Rv0167.2	1	3s45_478_B_201 PDB CREDO	0.604	0.174	0.551	0.005
Rv0167.2	1	1s9p_DES_D_600 PDB CREDO	0.717	0.069	0.550	0.005
Rv0167.2	1	3hec_STI_A_1 PDB CREDO	0.566	0.222	0.549	0.005
Rv0167.2	1	4dqe_017_B_101 PDB CREDO	0.652	0.122	0.546	0.005
Rv0167.2	1	3cs9_NIL_B_600 PDB CREDO	0.707	0.075	0.545	0.005
Rv0167.2	1	3v5w_8PR_A_701 PDB CREDO	0.599	0.181	0.544	0.005
Rv0167.2	1	3el9_DR7_A_100 PDB CREDO	0.725	0.063	0.543	0.006
Rv0167.2	1	3spk_TPV_A_100 PDB CREDO	0.638	0.136	0.543	0.006
Rv0167.2	1	3nu9_478_A_401 PDB CREDO	0.664	0.111	0.540	0.006
Rv0167.2	1	2z54_AB1_A_200 PDB CREDO	0.609	0.168	0.540	0.006
Rv0167.2	1	2aoj_FRD_C_305 PDB CREDO	0.608	0.169	0.539	0.006
Rv0167.2	1	1uwh_BAX_A_1723 PDB CREDO	0.556	0.236	0.539	0.006
Rv0167.2	1	1uwh_BAX_B_1723 PDB CREDO	0.556	0.236	0.539	0.006
Rv0167.2	1	1ohr_1UN_A_201 PDB CREDO	0.717	0.068	0.538	0.006
Rv0167.2	1	3erd_DES_A_600 PDB CREDO	0.726	0.062	0.537	0.006
Rv0167.2	1	3em6_017_A_200 PDB CREDO	0.660	0.115	0.537	0.006
Rv0167.2	1	3cs9_NIL_C_600 PDB CREDO	0.734	0.057	0.535	0.006
Rv0167.2	1	3rgf_BAX_A_465 PDB CREDO	0.638	0.137	0.534	0.006
Rv0167.2	1	1mx1_THA_C_3 PDB CREDO	0.694	0.086	0.532	0.007
Rv0167.2	1	2bpx_MK1_B_902 PDB CREDO	0.653	0.122	0.531	0.007
Rv0167.2	1	1hsh_MK1_C_402 PDB CREDO	0.709	0.074	0.531	0.007
Rv0167.2	1	1sh9_RIT_B_301 PDB CREDO	0.709	0.074	0.531	0.007
Rv0167.2	1	1opj_STI_A_3 PDB CREDO	0.671	0.105	0.531	0.007
Rv0167.2	1	3cs9_NIL_D_600 PDB CREDO	0.727	0.062	0.531	0.007
Rv0167.2	1	3ttp_017_A_201 PDB CREDO	0.652	0.123	0.531	0.007
Rv0167.2	1	3ogq_AB1_A_200 PDB CREDO	0.785	0.031	0.530	0.007
Rv0167.2	1	1sa1_POD_D_701 PDB CREDO	0.563	0.226	0.530	0.007
Rv0167.2	1	3n3i_ROC_A_201 PDB CREDO	0.667	0.108	0.528	0.007
Rv0167.2	1	1hpv_478_B_200 PDB CREDO	0.649	0.126	0.528	0.007
Rv0167.2	1	1opj_STI_B_4 PDB CREDO	0.667	0.109	0.528	0.007
Rv0167.2	1	3k5v_STI_B_2 PDB CREDO	0.613	0.164	0.528	0.007
Rv0167.2	1	3pyy_STI_A_3 PDB CREDO	0.613	0.164	0.528	0.007
Rv0167.2	1	1iep_STI_B_202 PDB CREDO	0.612	0.165	0.527	0.007
Rv0167.2	1	3mss_STI_B_1 PDB CREDO	0.612	0.165	0.527	0.007
Rv0167.2	1	3gvu_STI_A_1001 PDB CREDO	0.612	0.165	0.527	0.007
Rv0167.2	1	3ms9_STI_B_1 PDB CREDO	0.612	0.165	0.527	0.007
Rv0167.2	1	2qhc_AB1_B_9001 PDB CREDO	0.629	0.146	0.526	0.007
Rv0167.2	1	1iep_STI_A_201 PDB CREDO	0.611	0.166	0.526	0.007
Rv0167.2	1	2hyy_STI_A_600 PDB CREDO	0.611	0.166	0.526	0.007
Rv0167.2	1	2hyy_STI_D_600 PDB CREDO	0.611	0.166	0.526	0.007
Rv0167.2	1	3ms9_STI_A_1 PDB CREDO	0.611	0.166	0.526	0.007
Rv0167.2	1	3mss_STI_D_1 PDB CREDO	0.611	0.167	0.526	0.007
Rv0167.2	1	2hyy_STI_C_600 PDB CREDO	0.610	0.167	0.525	0.007
Rv0167.2	1	3mss_STI_A_1 PDB CREDO	0.610	0.167	0.525	0.007
Rv0167.2	1	3mss_STI_C_1 PDB CREDO	0.610	0.167	0.525	0.007
Rv0167.2	1	2b7z_MK1_B_200 PDB CREDO	0.609	0.169	0.524	0.008
Rv0167.2	1	3lzs_017_A_200 PDB CREDO	0.643	0.131	0.523	0.008
Rv0167.2	1	3pyy_STI_B_4 PDB CREDO	0.608	0.170	0.523	0.008
Rv0167.2	1	3oxw_017_B_200 PDB CREDO	0.661	0.114	0.523	0.008
Rv0167.2	1	1mx1_THA_E_5 PDB CREDO	0.732	0.058	0.523	0.008
Rv0167.2	1	3oht_1N1_B_1000 PDB CREDO	0.681	0.096	0.523	0.008
Rv0167.2	1	3oxw_017_D_200 PDB CREDO	0.659	0.116	0.521	0.008
Rv0167.2	1	2hw2_RFP_A_1200 PDB CREDO	0.537	0.262	0.521	0.008
Rv0167.2	1	2y6o_1N1_A_1892 PDB CREDO	0.555	0.238	0.521	0.008
Rv0167.2	1	3ekp_478_B_200 PDB CREDO	0.604	0.174	0.520	0.008
Rv0167.2	1	1s9p_DES_A_459 PDB CREDO	0.677	0.099	0.520	0.008
Rv0167.2	1	2idw_017_B_401 PDB CREDO	0.603	0.175	0.520	0.008
Rv0167.2	1	4dqh_017_B_101 PDB CREDO	0.655	0.119	0.519	0.008
Rv0167.2	1	1sa1_POD_B_700 PDB CREDO	0.567	0.220	0.518	0.008
Rv0167.2	1	3s53_017_A_201 PDB CREDO	0.654	0.121	0.518	0.008
Rv0167.2	1	3nu6_478_B_401 PDB CREDO	0.671	0.105	0.517	0.008
Rv0167.2	1	3k5v_STI_A_2 PDB CREDO	0.635	0.140	0.517	0.008
Rv0167.2	1	1t46_STI_A_3 PDB CREDO	0.706	0.076	0.515	0.009
Rv0167.2	1	2fxd_DR7_A_102 PDB CREDO	0.686	0.092	0.514	0.009
Rv0167.2	1	1a28_STR_B_2 PDB CREDO	0.547	0.248	0.514	0.009
Rv0167.2	1	3em4_DR7_A_100 PDB CREDO	0.684	0.093	0.513	0.009
Rv0167.2	1	1hxw_RIT_B_301 PDB CREDO	0.739	0.054	0.512	0.009
Rv0167.2	1	1d4s_TPV_A_201 PDB CREDO	0.602	0.177	0.512	0.009
Rv0167.2	1	4dqc_017_A_101 PDB CREDO	0.663	0.112	0.511	0.009
Rv0167.2	1	1sdv_MK1_B_902 PDB CREDO	0.699	0.082	0.510	0.009
Rv0167.2	1	3u7s_017_A_201 PDB CREDO	0.599	0.180	0.510	0.009
Rv0167.2	1	3t3c_017_A_201 PDB CREDO	0.658	0.117	0.507	0.010
Rv0167.2	1	1xkk_FMM_A_91 PDB CREDO	0.731	0.059	0.506	0.010
Rv0167.2	1	2q64_1UN_B_1001 PDB CREDO	0.788	0.029	0.506	0.010
Rv0167.2	1	2q5k_AB1_A_201 PDB CREDO	0.657	0.118	0.506	0.010
Rv0167.2	1	2f80_017_B_301 PDB CREDO	0.787	0.030	0.505	0.010
Rv0167.2	1	2qak_1UN_A_1001 PDB CREDO	0.787	0.030	0.505	0.010
Rv0167.2	1	2fum_MIX_D_3539 PDB CREDO	0.614	0.163	0.505	0.010
Rv0167.2	1	2pyn_1UN_A_1001 PDB CREDO	0.786	0.030	0.505	0.010
Rv0167.2	1	1uwj_BAX_B_1723 PDB CREDO	0.552	0.241	0.504	0.010
Rv0167.2	1	1jg2_ADN_A_500 PDB CREDO	0.633	0.142	0.503	0.010
Rv0167.2	1	2pym_1UN_A_1001 PDB CREDO	0.783	0.031	0.503	0.010
Rv0167.2	1	3e22_LOC_B_700 PDB CREDO	0.518	0.291	0.502	0.011
Rv0167.2	1	3e22_LOC_D_700 PDB CREDO	0.517	0.292	0.501	0.011
Rv0167.2	1	2q63_1UN_A_1001 PDB CREDO	0.780	0.033	0.501	0.011
Rv0167.2	1	3ggu_017_B_201 PDB CREDO	0.723	0.065	0.500	0.011
Rv0167.2	1	3sm2_478_A_126 PDB CREDO	0.760	0.042	0.500	0.011

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

No high confidence interactions