Rv0169

Tuberculist information
Gene namemce1A
Protein functionMce-family protein Mce1A
Functional category(tuberculist)virulence,detoxification and adaptaion
Gene location(kb)198.534
Molecular mass(da)47786.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 454
	  		  	1    MTTPGKLNKARVPPYKTAGLGLVLVFALVVALVYLQFRGEFTPKTQLTMLSARAGLVMDP   60
			  	61   GSKVTYNGVEIGRVDTISEVTRDGESAAKFILDVDPRYIHLIPANVNADIKATTVFGGKY  120
			  	121  VSLTTPKNPTKRRITPKDVIDVRSVTTEINTLFQTLTSIAEKVDPVKLNLTLSAAAEALT  180
			  	181  GLGDKFGESIVNANTVLDDLNSRMPQSRHDIQQLAALGDVYADAAPDLFDFLDSSVTTAR  240
			  	241  TINAQQAELDSALLAAAGFGNTTADVFDRGGPYLQRGVADLVPTATLLDTYSPELFCTIR  300
			  	301  NFYDADPLAKAASGGGNGYSLRTNSEILSGIGISLLSPLALATNGAAIGIGLVAGLIAPP  360
			  	361  LAVAANLAGALPGIVGGAPNPYTYPENLPRVNARGGPGGAPGCWQPITRDLWPAPYLVMD  420
			  	421  TGASLAPYNHMEVGSPYAVEYVWGRQVGDNTINP

Known structures in the PDB
No Known structures
1 46 91 136 181 226 271 316 361 406 451 Range: 44 to 126  |  Coverage: 18% MCE Range: 154 to 454  |  Coverage: 66% DUF3407 Range: 161 to 222  |  Coverage: 13% 1 Range: 60 to 166  |  Coverage: 23% 2 Range: 222 to 294  |  Coverage: 15% 3
Number of amino acids : 454
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
MCEPF0247044-126
DUF3407PF11887154-454
Mtb Structural Proteome models
Structure models not available for this query
Structure Models from Chopin
Model Number1
Profile1.20.5.1070
Click for model details
zscore6.08
Residue begin161
Residue end222
Model Number2
Profileb.45.3.1 - 2.40.30.80
Click for model details
zscore4.06
Residue begin60
Residue end166
Model Number3
Profile1.20.58.130
Click for model details
zscore4.01
Residue begin222
Residue end294
Binding pockets
Structure models not available for this query
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0169Gene nameConfidence Score
Rv0168yrbE1B0.974
Rv0167yrbE1A0.968
Rv0171mce1C0.947
Rv0174mce1F0.946
Rv0178Rv01780.943
Rv0170mce1B0.941
Rv0170mce1B0.941
Rv0175Rv01750.93
Rv0177Rv01770.929
Rv0173lprK0.923
Rv0172mce1D0.919
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions