Rv0168

Tuberculist information
Gene nameyrbE1B
Protein functionConserved integral membrane protein YrbE1B
Functional category(tuberculist)virulence,detoxification and adaptaion
Gene location(kb)197.66
Molecular mass(da)30281.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 289
	  		  	1    MSTAAVLRARFPRAVANLRQYGGAAARGLDEAGQLTWFALTSIGQIAHALRYYRKETLRL   60
			  	61   IAQIGMGTGAMAVVGGTVAIVGFVTLSGSSLVAIQGFASLGNIGVEAFTGFFAALINVRI  120
			  	121  AGPVVTGVALAATVGAGATAELGAMRISEEIDALEVMGIKSISFLASTRIMAGLVVIIPL  180
			  	181  YALAMIMSFLSPQITTTVLYGQSNGTYEHYFQTFLRPDDVFWSFLEALIITAIVMVSHCY  240
			  	241  YGYAAGGGPVGVGEAVGRSMRFSLVSVQVVVLFAALALYGVDPNFNLTV

Known structures in the PDB
No Known structures
1 29 57 85 113 141 169 197 225 253 281 Range: 55 to 278  |  Coverage: 77% Permease Range: 153 to 279  |  Coverage: 43% 1
Number of amino acids : 289
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
PermeasePF0240555-278
Mtb Structural Proteome models
Model Number1
Model nameRv0168
Template1E12    APDBCREDO
Template coverage38_182
Template Identity(%)16.5
Model coverage(%)43.6
Normalized DOPE score1.338

Structure Models from Chopin
CHOPIN models not available for this query
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0168Gene nameConfidence Score
Rv0174mce1F0.98
Rv0170mce1B0.975
Rv0170mce1B0.975
Rv0169mce1A0.974
Rv0169mce1A0.974
Rv0178Rv01780.96
Rv0167yrbE1A0.94
Rv0171mce1C0.94
Rv0172mce1D0.928
Rv0655mkl0.907
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions