Rv0215c

Tuberculist information
Gene namefadE3
Protein functionProbable acyl-CoA dehydrogenase FadE3
Functional category(tuberculist)lipid metabolism
Gene location(kb)257.783
Molecular mass(da)38616.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 357
	  		  	1    VRNELNDDEAMLVATVRAFIDRDVKPTVREVEHANSYPEAWIEQMKHIGIYGLAIDEQYG   60
			  	61   GSPVSMPCYVQVTQELARGWMSLAGAMGGHTVVAKLLTLFGTEEQRRTYLPPMASGELRA  120
			  	121  TMALTEPGGGSDLQNMSTTALADGPEGSAGLLINGCKTWISNARRSGLFAVLCKTDPNAT  180
			  	181  PRHQGMSIVLVEPGPGLTVSRDLPKLGYKGVESCELSFDNLRVPVSAILGGAMGQGFSQM  240
			  	241  MKGLETGRIQVAARALGVATAALEDSLAYAQQRESFGRPIWQHQAVGNYLADMATKLTAA  300
			  	301  RQLTRYAAERYDSGQRCDMEAGMAKLFASEVAMEIALNAVRIHGGYGYSTEYDVERR

Known structures in the PDB
No Known structures
1 36 71 106 141 176 211 246 281 316 351 Range: 6 to 117  |  Coverage: 31% Acyl-CoA_dh_N Range: 121 to 176  |  Coverage: 15% Acyl-CoA_dh_M Range: 234 to 357  |  Coverage: 34% Acyl-CoA_dh_1 Range: 3 to 356  |  Coverage: 98% 1 Range: 1 to 357  |  Coverage: 99% 1 Range: 234 to 356  |  Coverage: 34% 2 Range: 6 to 117  |  Coverage: 31% 3 Range: 1 to 236  |  Coverage: 65% 4
Number of amino acids : 357
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Acyl-CoA_dh_NPF027716-117
Acyl-CoA_dh_MPF02770121-176
Acyl-CoA_dh_1PF00441234-357
Mtb Structural Proteome models
Model Number1
Model nameRv0215c
Template2D29    APDBCREDO
Template coverage5_357
Template Identity(%)36.8
Model coverage(%)98.9
Normalized DOPE score-0.904

Structure Models from Chopin
Model Number1
Profile1.10.540.10, 2.40.110.10
Click for model details
zscore58.4
Residue begin1
Residue end357
Model Number2
Profilea.29.3.1
Click for model details
zscore32.63
Residue begin234
Residue end356
Model Number3
Profile1.10.540.10
Click for model details
zscore20.93
Residue begin6
Residue end117
Model Number4
Profilee.6.1.1
Click for model details
zscore16.74
Residue begin1
Residue end236
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0215cGene nameConfidence Score
Rv3774echA210.97
Rv2790cltp10.924
Rv2790cltp10.924
Rv1071cechA90.922
Rv0860fadB0.922
Rv1071cechA90.922
Rv0860fadB0.922
Rv0860fadB0.922
Rv1070cechA80.917
Rv2486echA140.917
Rv0632cechA30.912
Rv0222echA10.912
Rv3552Rv35520.911
Rv3561fadD30.911
Rv3561fadD30.911
Rv3551Rv35510.909
Rv0166fadD50.908
Rv0166fadD50.908
Rv1058fadD140.903
Rv1058fadD140.903
Rv3516echA190.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
flavin adenine dinucleotidePubChem0.943785.55
coenzyme APubChem0.909767.534
formatePubChem0.90245.0174
naphthyl-2-methyl-succinyl-CoAPubChem0.91007.79
NSC112207PubChem0.9785.55
c1137PubChem0.9875.672
H(+)PubChem0.92.01588
FADH2PubChem0.9787.566
deuteriumPubChem0.92.01588
C16468PubChem0.9875.672
pyrophosphatePubChem0.9177.975
adenosine triphosphatePubChem0.9507.181
5-methylhex-4-enoyl-CoAPubChem0.9877.688
AR-1A9122PubChem0.9787.566
Co-APubChem0.9767.534
1,5-dihydro-FADPubChem0.9787.566
protiumPubChem0.92.01576
hydroxyl radicalsPubChem0.917.0073
adenosine monophosphatePubChem0.9347.221