Rv3516

Tuberculist information
Gene nameechA19
Protein functionPossible enoyl-CoA hydratase EchA19 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Functional category(tuberculist)lipid metabolism
Gene location(kb)3952.54
Molecular mass(da)28216.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 263
	  		  	1    VESGPDALVERRGHTLIVTMNRPAARNALSTEMMRIMVQAWDRVDNDPDIRCCILTGAGG   60
			  	61   YFCAGMDLKAATQKPPGDSFKDGSYGPSRIDALLKGRRLTKPLIAAVEGPAIAGGTEILQ  120
			  	121  GTDIRVAGESAKFGISEAKWSLYPMGGSAVRLVRQIPYTLACDLLLTGRHITAAEAKEMG  180
			  	181  LIGHVVPDGQALTKALELADAISANGPLAVQAILRSIRETECMPENEAFKIDTQIGIKVF  240
			  	241  LSDDAKEGPRAFAEKRAPNFQNR

Known structures in the PDB
No Known structures
1 27 53 79 105 131 157 183 209 235 261 Range: 8 to 255  |  Coverage: 93% ECH Range: 8 to 262  |  Coverage: 96% 1 Range: 1 to 263  |  Coverage: 99% 1 Range: 204 to 263  |  Coverage: 22% 2
Number of amino acids : 263
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ECHPF003788-255
Mtb Structural Proteome models
Model Number1
Model nameRv3516
Template1HZD    APDBCREDO
Template coverage82_338
Template Identity(%)32.2
Model coverage(%)96.6
Normalized DOPE score-0.408

Structure Models from Chopin
Model Number1
Profilec.14.1.3 - 3.90.226.10
Click for model details
zscore34.52
Residue begin1
Residue end263
Model Number2
Profile1.10.12.10
Click for model details
zscore16.84
Residue begin204
Residue end263
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3516Gene nameConfidence Score
Rv3505fadE270.963
Rv3544cfadE280.963
Rv0468fadB20.963
Rv3505fadE270.963
Rv3544cfadE280.963
Rv0468fadB20.963
Rv3504fadE260.957
Rv3504fadE260.957
Rv3504fadE260.957
Rv3573cfadE340.94
Rv3573cfadE340.94
Rv3573cfadE340.94
Rv3543cfadE290.937
Rv3543cfadE290.937
Rv3543cfadE290.937
Rv0672fadE80.928
Rv0672fadE80.928
Rv1467cfadE150.926
Rv0244cfadE50.926
Rv1467cfadE150.926
Rv0244cfadE50.926
Rv1467cfadE150.926
Rv0244cfadE50.926
Rv0244cfadE50.926
Rv1467cfadE150.926
Rv1467cfadE150.926
Rv0244cfadE50.926
Rv1715fadB30.925
Rv1715fadB30.925
Rv3563fadE320.922
Rv3563fadE320.922
Rv0972cfadE120.92
Rv0972cfadE120.92
Rv0972cfadE120.92
Rv3562fadE310.918
Rv1679fadE160.918
Rv1934cfadE170.918
Rv3562fadE310.918
Rv1679fadE160.918
Rv1934cfadE170.918
Rv3562fadE310.918
Rv1679fadE160.918
Rv1934cfadE170.918
Rv3564fadE330.917
Rv1933cfadE180.917
Rv3564fadE330.917
Rv1933cfadE180.917
Rv0860fadB0.916
Rv3797fadE350.916
Rv3797fadE350.916
Rv0860fadB0.916
Rv0860fadB0.916
Rv0154cfadE20.915
Rv0131cfadE10.915
Rv0131cfadE10.915
Rv2502caccD10.915
Rv0131cfadE10.915
Rv0231fadE40.915
Rv0154cfadE20.915
Rv0231fadE40.915
Rv0154cfadE20.915
Rv3513cfadD180.914
Rv0271cfadE60.914
Rv0271cfadE60.914
Rv3513cfadD180.914
Rv0271cfadE60.914
Rv3560cfadE300.913
Rv3061cfadE220.913
Rv3560cfadE300.913
Rv3061cfadE220.913
Rv3061cfadE220.913
Rv3560cfadE300.913
Rv3274cfadE250.909
Rv3274cfadE250.909
Rv3274cfadE250.909
Rv3761cfadE360.908
Rv2500cfadE190.907
Rv2500cfadE190.907
Rv2500cfadE190.907
Rv2724cfadE200.906
Rv0400cfadE70.906
Rv0400cfadE70.906
Rv0400cfadE70.906
Rv2724cfadE200.906
Rv2724cfadE200.906
Rv0752cfadE90.905
Rv0752cfadE90.905
Rv0752cfadE90.905
Rv0215cfadE30.901
Rv0215cfadE30.901
Rv0215cfadE30.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
crotonyl-CoAPubChem0.913835.608
coenzyme APubChem0.909767.534
3-hydroxybutyryl-CoAPubChem0.905853.623
methacrylyl-CoAPubChem0.904835.608
acryloyl-CoAPubChem0.904821.581
3-hydroxypropionyl-CoAPubChem0.903839.597
2-methylacetoacetyl-coenzyme APubChem0.9865.634
3-hydroxypropionyl-coenzyme APubChem0.9839.597
flavin adenine dinucleotidePubChem0.9785.55
C11945PubChem0.9917.752
C0885PubChem0.9917.752
trans-2-enoyl-CoAsPubChem0.9821.581
2-methylacetoacetyl-CoAPubChem0.9865.634
C01144PubChem0.9853.623
c0887PubChem0.9935.767
deuteriumPubChem0.92.01588
protiumPubChem0.92.01576
NSC112207PubChem0.9785.55
c1138PubChem0.9893.687
C05260PubChem0.9993.889
3-hydroxyadipyl-CoAPubChem0.9911.659
C05271PubChem0.9863.661
2MCPubChem0.9835.608
CHEBI:15477PubChem0.9851.651
H(+)PubChem0.92.01588
3-hydroxydecanoyl-CoAPubChem0.9937.783
C05258PubChem0.91021.94
C05273PubChem0.9975.874
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
C16469PubChem0.9893.687
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
C05268PubChem0.9881.677
C11947PubChem0.9935.767
C03221PubChem0.9947.821
methylcrotonyl CoAPubChem0.9849.635
2-methyl-3-hydroxybutyryl-CoAPubChem0.9867.65
alpha-methylbutyryl-CoAPubChem0.9851.651
C05989PubChem0.9837.581
1,5-dihydro-FADPubChem0.9787.566
C14145PubChem0.9911.659
c1137PubChem0.9875.672
3-hydroxyhexadecanoyl-CoAPubChem0.91021.94
2-methylbutyryl-CoAPubChem0.9851.651
FADH2PubChem0.9787.566
C05275PubChem0.9919.768
isobutyryl-CoAPubChem0.9837.624
C11946PubChem0.9917.752
AR-1A9122PubChem0.9787.566
C05262PubChem0.9965.836
3-methylcrotonyl-CoAPubChem0.9849.635
C04405PubChem0.9867.65
trans-2-hexadecenoyl-CoAPubChem0.91003.93
NAD+PubChem0.9663.425
C16468PubChem0.9875.672
AR-1H5729PubChem0.9835.608
C05266PubChem0.9909.73
C05276PubChem0.9891.714
hydroxyl radicalsPubChem0.917.0073
CHEBI:15489PubChem0.9837.581
Co-APubChem0.9767.534