Tuberculist information
Gene namefadE34
Protein functionProbable acyl-CoA dehydrogenase FadE34
Functional category(tuberculist)lipid metabolism
Gene location(kb)4014.08
Molecular mass(da)74546.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 711
	  		  	1    VVATVTDEQSAARELVRGWARTAASGAAATAAVRDMEYGFEEGNADAWRPVFAGLAGLGL   60
			  	61   FGVAVPEDCGGAGGSIEDLCAMVDEAARALVPGPVATTAVATLVVSDPKLRSALASGERF  120
			  	121  AGVAIDGGVQVDPKTSTASGTVGRVLGGAPGGVVLLPADGNWLLVDTACDEVVVEPLRAT  180
			  	181  DFSLPLARMVLTSAPVTVLEVSGERVEDLAATVLAAEAAGVARWTLDTAVAYAKVREQFG  240
			  	241  KPIGSFQAVKHLCAQMLCRAEQADVAAADAARAAADSDGTQLSIAAAVAASIGIDAAKAN  300
			  	301  AKDCIQVLGGIGCTWEHDAHLYLRRAHGIGGFLGGSGRWLRRVTALTQAGVRRRLGVDLA  360
			  	361  EVAGLRPEIAAAVAEVAALPEEKRQVALADTGLLAPHWPAPYGRGASPAEQLLIDQELAA  420
			  	421  AKVERPDLVIGWWAAPTILEHGTPEQIERFVPATMRGEFLWCQLFSEPGAGSDLASLRTK  480
			  	481  AVRADGGWLLTGQKVWTSAAHKARWGVCLARTDPDAPKHKGITYFLVDMTTPGIEIRPLR  540
			  	541  EITGDSLFNEVFLDNVFVPDEMVVGAVNDGWRLARTTLANERVAMATGTALGNPMEELLK  600
			  	601  VLGDMELDVAQQDRLGRLILLAQAGALLDRRIAELAVGGQDPGAQSSVRKLIGVRYRQAL  660
			  	661  AEYLMEVSDGGGLVENRAVYDFLNTRCLTIAGGTEQILLTVAAERLLGLPR
			  			

Known structures in the PDB
No Known structures
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Acyl-CoA_dh_NPF027716-113
Acyl-CoA_dh_1PF00441204-347
Acyl-CoA_dh_NPF02771359-458
Acyl-CoA_dh_MPF02770462-513
Acyl-CoA_dh_1PF00441568-707
Mtb Structural Proteome models
Model Number1
Model nameRv3573c
Template1JQI    APDBCREDO
Template coverage5_383
Template Identity(%)24.4
Model coverage(%)51.2
Normalized DOPE score-0.202

Model Number2
Model nameRv3573c.1
Template2C12    APDBCREDO
Template coverage2_429
Template Identity(%)19.2
Model coverage(%)50.5
Normalized DOPE score0.52

Structure Models from Chopin
Model Number1
Profilee.6.1.1
Click for model details
zscore12.13
Residue begin462
Residue end513
Model Number2
Profilea.29.3.1
Click for model details
zscore10.61
Residue begin204
Residue end347
Model Number3
Profilea.29.3.1
Click for model details
zscore10.61
Residue begin568
Residue end711
Model Number4
Profile1.10.540.10, 1.20.140.10, 2.40.110.10
Click for model details
zscore4.83
Residue begin1
Residue end108
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3573cGene nameConfidence Score
Rv3516echA190.94
Rv3774echA210.907
Potential ligand/drug binding sites
Protein ModelPocket NumberDrug Binding Site PMIN ScorePvalue PMINPMAX ScorePvalue PMAX
Rv3573c.151sa1_POD_B_700PDBCREDO0.7320.0580.6910.000
Rv3573c.153spk_TPV_B_100PDBCREDO0.7070.0760.6870.000
Rv3573c.151n49_RIT_D_401PDBCREDO0.6850.0930.6850.000
Rv3573c.151sa1_POD_D_701PDBCREDO0.7400.0530.6780.000
Rv3573c.113vkx_T3_A_301PDBCREDO0.6920.0870.6600.001
Rv3573c.151n49_RIT_B_301PDBCREDO0.7020.0790.6450.001
Rv3573c.153so9_017_A_100PDBCREDO0.7200.0660.6390.001
Rv3573c.153e22_LOC_B_700PDBCREDO0.7430.0520.6200.001
Rv3573c.153e22_LOC_D_700PDBCREDO0.7430.0520.6200.001
Rv3573c.153el0_1UN_A_201PDBCREDO0.6400.1350.6040.002
Rv3573c.152nni_MTK_A_501PDBCREDO0.6180.1580.6000.002
Rv3573c.151c6y_MK1_B_524PDBCREDO0.6880.0900.5990.002
Rv3573c.151xkk_FMM_A_91PDBCREDO0.7430.0520.5970.002
Rv3573c.112nnj_225_A_501PDBCREDO0.6570.1170.5970.002
Rv3573c.153ut5_LOC_B_502PDBCREDO0.6720.1040.5970.002
Rv3573c.153lzv_017_A_200PDBCREDO0.6300.1450.5950.002
Rv3573c.111ya4_CTX_B_2PDBCREDO0.8390.0130.5950.002
Rv3573c.111ya4_CTX_C_3PDBCREDO0.8370.0130.5930.002
Rv3573c.153ekq_ROC_A_100PDBCREDO0.6630.1120.5930.002
Rv3573c.153spk_TPV_A_100PDBCREDO0.7980.0260.5850.003
Rv3573c.111xbb_STI_A_1PDBCREDO0.6390.1350.5800.003
Rv3573c.112bdm_TMI_A_502PDBCREDO0.6390.1350.5800.003
Rv3573c.153ut5_LOC_D_502PDBCREDO0.6940.0850.5800.003
Rv3573c.113hbb_TMQ_A_611PDBCREDO0.5760.2090.5760.003
Rv3573c.151sgu_MK1_B_2632PDBCREDO0.5730.2120.5730.003
Rv3573c.113ug2_IRE_A_1PDBCREDO0.6280.1470.5700.004
Rv3573c.152r5q_1UN_B_900PDBCREDO0.5870.1950.5700.004
Rv3573c.152r5q_1UN_D_900PDBCREDO0.5870.1950.5700.004
Rv3573c.153gp0_NIL_A_1PDBCREDO0.6900.0880.5700.004
Rv3573c.113clb_TMQ_C_613PDBCREDO0.5690.2180.5690.004
Rv3573c.151t7j_478_A_200PDBCREDO0.6400.1340.5690.004
Rv3573c.152q64_1UN_B_1001PDBCREDO0.7620.0410.5680.004
Rv3573c.152qxs_RAL_B_600PDBCREDO0.6350.1390.5680.004
Rv3573c.153ogp_017_B_200PDBCREDO0.5660.2210.5660.004
Rv3573c.152qak_1UN_A_1001PDBCREDO0.7590.0430.5660.004
Rv3573c.113b2r_VDN_A_1PDBCREDO0.6200.1560.5660.004
Rv3573c.151hwk_117_B_1PDBCREDO0.5650.2230.5650.004
Rv3573c.152pym_1UN_A_1001PDBCREDO0.7580.0440.5650.004
Rv3573c.152qxs_RAL_A_600PDBCREDO0.6310.1440.5640.004
Rv3573c.153ufn_ROC_A_401PDBCREDO0.6830.0950.5640.004
Rv3573c.153ogp_017_A_200PDBCREDO0.6150.1620.5630.004
Rv3573c.113n8y_DIF_B_585PDBCREDO0.5630.2270.5630.004
Rv3573c.111mx1_THA_A_1PDBCREDO0.7020.0790.5620.004
Rv3573c.152pyn_1UN_A_1001PDBCREDO0.7540.0460.5620.004
Rv3573c.113b2r_VDN_B_1PDBCREDO0.6150.1620.5610.004
Rv3573c.151t46_STI_A_3PDBCREDO0.6610.1140.5600.004
Rv3573c.152q63_1UN_A_1001PDBCREDO0.7510.0470.5600.004
Rv3573c.111mx1_THA_B_2PDBCREDO0.7290.0610.5600.004
Rv3573c.151jg2_ADN_A_500PDBCREDO0.8170.0190.5590.004
Rv3573c.111r9o_FLP_A_501PDBCREDO0.5860.1960.5590.004
Rv3573c.111mx1_THA_D_4PDBCREDO0.7830.0320.5550.005
Rv3573c.111xoz_CIA_A_501PDBCREDO0.5790.2050.5530.005
Rv3573c.154asd_BAX_A_1500PDBCREDO0.5850.1980.5520.005
Rv3573c.153el9_DR7_A_100PDBCREDO0.6320.1430.5500.005
Rv3573c.113clb_TMQ_B_612PDBCREDO0.5760.2090.5500.005
Rv3573c.153gcs_BAX_A_401PDBCREDO0.5830.2010.5490.005
Rv3573c.111mx1_THA_F_6PDBCREDO0.7740.0350.5480.005
Rv3573c.112w8y_NDR_B_1000PDBCREDO0.7730.0360.5470.005
Rv3573c.113ads_IMN_B_3PDBCREDO0.6510.1230.5440.006
Rv3573c.153sm2_478_A_126PDBCREDO0.7090.0740.5420.006
Rv3573c.113mdt_VOR_B_506PDBCREDO0.6960.0840.5420.006
Rv3573c.152jfa_RAL_A_600PDBCREDO0.6470.1270.5400.006
Rv3573c.151c6z_ROC_B_505PDBCREDO0.7250.0630.5400.006
Rv3573c.151uwj_BAX_A_1723PDBCREDO0.5560.2360.5400.006
Rv3573c.113pgh_FLP_B_701PDBCREDO0.5650.2240.5390.006
Rv3573c.113mdt_VOR_A_506PDBCREDO0.6880.0900.5360.006
Rv3573c.151rl8_RIT_A_9001PDBCREDO0.7360.0560.5350.006
Rv3573c.153bbt_FMM_D_91PDBCREDO0.7530.0460.5340.006
Rv3573c.151hsh_MK1_A_401PDBCREDO0.6120.1640.5330.007
Rv3573c.152jfa_RAL_B_600PDBCREDO0.6180.1580.5330.007
Rv3573c.112bxf_DZP_B_2001PDBCREDO0.5570.2340.5320.007
Rv3573c.151hsh_MK1_C_402PDBCREDO0.6100.1670.5310.007
Rv3573c.153ogq_AB1_A_200PDBCREDO0.6770.1000.5300.007
Rv3573c.113tmz_06X_A_503PDBCREDO0.6350.1400.5300.007
Rv3573c.153h52_486_B_1PDBCREDO0.5780.2060.5300.007
Rv3573c.113r9c_ECL_A_451PDBCREDO0.6450.1290.5290.007
Rv3573c.153ggu_017_B_201PDBCREDO0.6580.1170.5290.007
Rv3573c.153heg_BAX_A_1PDBCREDO0.5780.2070.5290.007
Rv3573c.113fl9_TOP_G_200PDBCREDO0.6440.1310.5280.007
Rv3573c.113jw5_TOP_A_208PDBCREDO0.6440.1310.5280.007
Rv3573c.113uq6_ADN_B_401PDBCREDO0.5280.2750.5280.007
Rv3573c.113adx_IMN_B_3PDBCREDO0.7170.0690.5280.007
Rv3573c.151err_RAL_A_600PDBCREDO0.6130.1640.5280.007
Rv3573c.151err_RAL_B_600PDBCREDO0.6130.1640.5280.007
Rv3573c.113jw5_TOP_B_208PDBCREDO0.6420.1320.5270.007
Rv3573c.112bxf_DZP_A_2001PDBCREDO0.5510.2420.5260.007
Rv3573c.113hm1_J3Z_A_2PDBCREDO0.5500.2430.5250.007
Rv3573c.113uq6_ADN_A_401PDBCREDO0.5250.2800.5250.007
Rv3573c.152y6o_1N1_A_1892PDBCREDO0.6480.1260.5240.008
Rv3573c.152b7z_MK1_B_200PDBCREDO0.5240.2820.5240.008
Rv3573c.113ols_EST_A_600PDBCREDO0.7100.0730.5230.008
Rv3573c.113ols_EST_B_600PDBCREDO0.7100.0730.5230.008
Rv3573c.111pcg_EST_B_2PDBCREDO0.5480.2470.5230.008
Rv3573c.112jap_J01_A_1249PDBCREDO0.5480.2460.5230.008
Rv3573c.151sh9_RIT_B_301PDBCREDO0.6000.1790.5220.008
Rv3573c.153h52_486_D_2PDBCREDO0.5880.1940.5220.008
Rv3573c.113fl9_TOP_B_200PDBCREDO0.6360.1390.5220.008
Rv3573c.111ere_EST_B_600PDBCREDO0.5460.2500.5210.008
Rv3573c.111tbf_VIA_A_501PDBCREDO0.5460.2500.5210.008
Rv3573c.111xp0_VDN_A_201PDBCREDO0.6230.1520.5210.008
Rv3573c.112jap_J01_C_1249PDBCREDO0.5460.2500.5200.008
Rv3573c.111ere_EST_A_600PDBCREDO0.5450.2510.5200.008
Rv3573c.152o4p_TPV_A_300PDBCREDO0.5350.2650.5200.008
Rv3573c.112jap_J01_D_1249PDBCREDO0.5450.2510.5190.008
Rv3573c.153h52_486_A_3PDBCREDO0.5850.1980.5190.008
Rv3573c.112jap_J01_B_1249PDBCREDO0.5440.2530.5180.008
Rv3573c.111g50_EST_B_1600PDBCREDO0.5430.2540.5180.008
Rv3573c.113fl9_TOP_A_200PDBCREDO0.6300.1450.5170.008
Rv3573c.111ere_EST_E_600PDBCREDO0.5420.2560.5170.008
Rv3573c.111gwr_EST_A_600PDBCREDO0.5420.2560.5170.008
Rv3573c.111qku_EST_A_600PDBCREDO0.5420.2560.5170.008
Rv3573c.111qku_EST_C_600PDBCREDO0.5420.2560.5170.008
Rv3573c.151hwk_117_A_2PDBCREDO0.5480.2470.5170.008
Rv3573c.153oez_STI_A_601PDBCREDO0.5170.2920.5170.008
Rv3573c.151hwk_117_C_4PDBCREDO0.5470.2480.5160.009
Rv3573c.113hbb_TMQ_C_613PDBCREDO0.5910.1890.5160.009
Rv3573c.151hwl_FBI_B_1PDBCREDO0.5640.2250.5160.009
Rv3573c.151hwl_FBI_D_3PDBCREDO0.5640.2250.5160.009
Rv3573c.111g50_EST_A_600PDBCREDO0.7000.0810.5160.009
Rv3573c.111gwr_EST_B_600PDBCREDO0.5400.2580.5160.009
Rv3573c.111qku_EST_B_600PDBCREDO0.5400.2580.5160.009
Rv3573c.153frq_ERY_A_195PDBCREDO0.5310.2720.5160.009
Rv3573c.113grv_ADN_A_300PDBCREDO0.5150.2950.5150.009
Rv3573c.152oax_SNL_E_5001PDBCREDO0.5620.2270.5150.009
Rv3573c.112yja_EST_B_1550PDBCREDO0.6980.0830.5140.009
Rv3573c.113uud_EST_A_600PDBCREDO0.6980.0830.5140.009
Rv3573c.152z54_AB1_A_200PDBCREDO0.5290.2740.5140.009
Rv3573c.112w9s_TOP_A_1160PDBCREDO0.6260.1490.5140.009
Rv3573c.152f80_017_B_301PDBCREDO0.6890.0890.5140.009
Rv3573c.153ebz_017_B_201PDBCREDO0.5280.2750.5130.009
Rv3573c.112w3v_TOP_A_1169PDBCREDO0.5380.2610.5130.009
Rv3573c.113uud_EST_B_600PDBCREDO0.6950.0840.5130.009
Rv3573c.152o4n_TPV_A_300PDBCREDO0.5770.2070.5130.009
Rv3573c.152oax_SNL_D_4001PDBCREDO0.5600.2300.5130.009
Rv3573c.152oax_SNL_F_6001PDBCREDO0.5600.2300.5130.009
Rv3573c.113clb_TMQ_A_611PDBCREDO0.5870.1950.5120.009
Rv3573c.113clb_TMQ_D_614PDBCREDO0.5120.3000.5120.009
Rv3573c.152qhc_AB1_B_9001PDBCREDO0.5260.2780.5110.009
Rv3573c.152oax_SNL_A_1001PDBCREDO0.5580.2330.5110.009
Rv3573c.111udu_CIA_B_2003PDBCREDO0.6110.1660.5110.009
Rv3573c.151ohr_1UN_A_201PDBCREDO0.5870.1950.5110.009
Rv3573c.151uwj_BAX_B_1723PDBCREDO0.5410.2560.5110.009
Rv3573c.113hbb_TMQ_D_614PDBCREDO0.5110.3020.5110.009
Rv3573c.112w9s_TOP_C_1160PDBCREDO0.6210.1550.5090.009
Rv3573c.151jg3_ADN_A_500PDBCREDO0.8280.0160.5090.009
Rv3573c.153oht_1N1_B_1000PDBCREDO0.7700.0370.5090.010
Rv3573c.153tkd_CYZ_B_267PDBCREDO0.5720.2130.5080.010
Rv3573c.112w9h_TOP_A_1160PDBCREDO0.5330.2690.5080.010
Rv3573c.111qhs_CLM_A_999PDBCREDO0.5600.2310.5080.010
Rv3573c.151k6c_MK1_B_902PDBCREDO0.7510.0470.5080.010
Rv3573c.151d4y_TPV_A_501PDBCREDO0.5720.2140.5080.010
Rv3573c.151uwh_BAX_B_1723PDBCREDO0.5720.2140.5080.010
Rv3573c.151uwh_BAX_A_1723PDBCREDO0.5720.2150.5080.010
Rv3573c.152bpx_MK1_B_902PDBCREDO0.5370.2620.5070.010
Rv3573c.153el4_ROC_A_100PDBCREDO0.7490.0490.5060.010
Rv3573c.153oy4_017_B_200PDBCREDO0.5200.2870.5060.010
Rv3573c.151hxb_ROC_A_100PDBCREDO0.6770.1000.5050.010
Rv3573c.111mx1_THA_E_5PDBCREDO0.8290.0150.5040.010
Rv3573c.112uxp_CLM_B_1211PDBCREDO0.5280.2750.5040.010
Rv3573c.152pl0_STI_A_200PDBCREDO0.5500.2430.5040.010
Rv3573c.153el5_1UN_B_201PDBCREDO0.6590.1160.5030.010
Rv3573c.112uxp_CLM_A_1211PDBCREDO0.5270.2770.5030.010
Rv3573c.152w8y_486_A_1000PDBCREDO0.5330.2680.5030.010
Rv3573c.151t7i_017_A_200PDBCREDO0.7430.0520.5030.010
Rv3573c.153s56_ROC_A_201PDBCREDO0.5770.2080.5020.011
Rv3573c.151hwl_FBI_A_2PDBCREDO0.5480.2470.5010.011
Rv3573c.151hxw_RIT_B_301PDBCREDO0.6230.1530.5010.011
Rv3573c.151hwl_FBI_C_4PDBCREDO0.5470.2480.5010.011
Rv3573c.111pcg_EST_A_1PDBCREDO0.5990.1800.5000.011
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
pyrophosphatePubChem0.9177.975
adenosine triphosphatePubChem0.9507.181
NSC112207PubChem0.9785.55
coenzyme APubChem0.9767.534
H(+)PubChem0.92.01588
1,5-dihydro-FADPubChem0.9787.566
FADH2PubChem0.9787.566
hydroxyl radicalsPubChem0.917.0073
adenosine monophosphatePubChem0.9347.221
formatePubChem0.945.0174
AR-1A9122PubChem0.9787.566
flavin adenine dinucleotidePubChem0.9785.55
Co-APubChem0.9767.534
deuteriumPubChem0.92.01588
protiumPubChem0.92.01576